- The use of high-resolution colonic manometry to establish etiology and direct treatment in patients with constipation: case series with correlation to histology. [Journal Article]
- JGJ Gastroenterol Hepatol 2018 May 23
- CONCLUSIONS: Different types of constipation showed different colonic motility patterns and morphological changes in the colonic wall. HRCM plays an important role in the diagnosis and classification of patients with constipation. Furthermore, HRCM can accurately identify the diseased colonic segments and help to choose the appropriate treatment.
- Contribution of NRF2 in Gastrointestinal Protection From Oxidative Injury. [Journal Article]
- CPCurr Pharm Des 2018 May 21
- The human gastrointestinal tract is exposed to a variety of toxic agents, such as Helicobacter pylori (H.pylori), nonsteroidal anti-inflammatory drugs (NSAIDs), gastric acid, enteric pathogenic bacte...
The human gastrointestinal tract is exposed to a variety of toxic agents, such as Helicobacter pylori (H.pylori), nonsteroidal anti-inflammatory drugs (NSAIDs), gastric acid, enteric pathogenic bacteria, excessive auto immune reactions, and chronic mental stresses. These stressors generate free radicals within the gastrointestinal tissues, causing chronic inflammatory diseases, ulcers, cancers, and functional disturbances. Recent studies have demonstrated that some natural food compounds upregulate the nuclear factor erythroid 2-related factor 2-mediated antioxidant system, ameliorating or preventing these disorders. We have previously shown that dietary intake of sulforaphane-rich broccoli sprouts, ameliorates gastric inflammation induced by H. pylori, prevents NSAIDs-induced small intestinal injury, and improve functional constipation. There have been many other compounds, which enhance the nuclear factor erythroid 2-related factor 2-mediated antioxidant system, sufficient evidence for their clinical efficacy has not yet been provided. In addition, we have to pay attention to some reports, which have shown that excessive stimulation of nuclear factor erythroid 2-related factor 2 enhance chemoresistance and facilitates growth of cancer cells.
- Exploiting significance of physical exercise in prevention of gastrointestinal disorders. [Journal Article]
- CPCurr Pharm Des 2018 May 21
- CONCLUSIONS: Physical activity can exhibit a beneficial effect on a variety of gastrointestinal diseases, however, this effect depends upon the exercise mode, duration and intensity. The accumulated evidence indicate that management of gastrointestinal problems and their relief by the exercise seems to be complicated and require adjustments of physical activity training, dietary measures and medical monitoring of symptoms. More experimental and clinical studies on the effects of physical activity on GI-tract disorders are warranted. Especially, the association between the exercise intensity and data addressing the underlying mechanism(s) of the exercise as the complementary therapy in the treatment of gastrointestinal disorders, require further determination in animal models and humans.
- Primary vaginal endometrial stromal sarcoma associated with endometriosis: a case report with a review of the literature. [Journal Article]
- EJEur J Gynaecol Oncol 2016; 37(5):717-721
- Extrauterine endometrial stromal sarcomas (ESSs) are quite rare tumors, and vagina is an unusual site for these tumors. This paper presents a very rare pathological entity of primary vaginal ESS. A 4...
Extrauterine endometrial stromal sarcomas (ESSs) are quite rare tumors, and vagina is an unusual site for these tumors. This paper presents a very rare pathological entity of primary vaginal ESS. A 46-year-old woman with a complaint of postcoital vaginal bleeding, low abdominal pain, and constipation was admitted to the clinic. She had a mass of seven cm in size, located in the posterior fornix detected on physical examination. The preoperative biopsy showed ESS, surgical material, and evaluation of an endometrium confirmed the diagnosis of primary vaginal ESS. She underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and partial vaginectomy. The diagnosis of ESS performed by pathologic and immunohistochemical evaluation was: caldesmon (-), actin (-), desmin (-). CDIO (+), ER (+), PR (+), and vimentin (+). There was no ESS lesion in the endometrium. The patient was free of tumor for 22 months after the surgery without any additional therapy. In this study, the authors report the sixth case of primary vaginal ESS in the literature and aim to discuss diagnostic criteria and management protocols in the light of the literature.
- Premenopausal women with recurrent urinary tract infections have lower quality of life. [Journal Article]
- IJInt J Urol 2018 May 22
- CONCLUSIONS: Recurrent acute uncomplicated urinary tract infection has a negative impact on the quality of life of premenopausal, otherwise healthy women. Recurrent acute uncomplicated urinary tract infection patients who also have chronic constipation or consume caffeine have lower quality of life than those who do not. More studies are required to understand the relationships between these common problems and risk factors.
- Ocular toxoplasmosis: adverse reactions to treatment in a Brazilian cohort. [Journal Article]
- TRTrans R Soc Trop Med Hyg 2018 May 19
- CONCLUSIONS: Our results suggest a high rate of ADRs to OT classic treatment, which requires careful follow-up in order to identify and treat ADRs early.
- In Vivo Profiling of Four Centrally Administered Opioids for Antinociception, Constipation and Respiratory Depression: Between Colony Differences in Sprague Dawley Rats. [Journal Article]
- CEClin Exp Pharmacol Physiol 2018 May 22
- Outbred rodent stocks including Sprague Dawley rats, are known for their genetic diversity and so they are often used to develop animal models of human disease. Although between-colony differences in...
Outbred rodent stocks including Sprague Dawley rats, are known for their genetic diversity and so they are often used to develop animal models of human disease. Although between-colony differences in pharmaco-behavioural studies have been published previously, a direct head-to-head comparison study, whereby all research was performed in the same laboratory by the same experimenter utilising the supraspinal route of drug administration in the same strain of rat, is lacking. Herein, we report our head-to-head comparison study, involving assessment of antinociception, constipation and respiratory depression evoked by single bolus intracerebroventricular (ICV) doses of morphine, buprenorphine, DPDPE and U69,593 using male Sprague Dawley rats sourced from a different breeding colony (BC2) from that (BC1) used by us previously. Our data show that there are marked differences in the potency rank order for morphine and buprenorphine between rats sourced from BC2 and BC1. Although ICV morphine evoked a bell-shaped dose-response curve in the constipation test for rats from both colonies, this occurred at higher doses for rats from BC2. In conclusion, our head-to-head comparison shows considerable between-colony differences for the same rat strain, in the potency rank order of two clinically important strong opioid analgesics given by the ICV route. This article is protected by copyright. All rights reserved.
- Incidence and risk factors for positive urine culture at the time of pediatric urologic surgery. [Journal Article]
- IUInt Urol Nephrol 2018 May 21
- CONCLUSIONS: Patients with neurogenic bladder, prior positive urine culture, constipation, female gender, and urolithiasis were at increased risk for positive intraoperative urine culture. This may aid in decision-making regarding obtaining preoperative or intraoperative urine cultures in pediatric urology patients.
- Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase C Activation in Reversing Bladder-Colon Cross Sensitization. [Journal Article]
- JPJ Pharmacol Exp Ther 2018 May 21
- CONCLUSIONS: Our findings suggest a novel treatment paradigm for GC-C agonism in IBS-C and BPS mediated through visceral organ crosstalk, a mechanism not previously linked to linaclotide.
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- [Features of the course of irritable bowel syndrome in patients with excess body weight]. [Journal Article]
- WLWiad Lek 2018; 71(3 pt 2):688-690
- CONCLUSIONS: Conclusions: Irritable bowel syndrome was revealed in 51.7% of obese patients. Significant prevalence of combined pathology was noted in females. The prevalence of irritable bowel syndrome with diarrhea was determined.