- Ingestible Contrast Agents for Gastrointestinal Imaging. [Journal Article]
- CChembiochem 2018 Nov 12
- Gastrointestinal (GI) ailments cover a wide variety of diseases involving the esophagus, stomach, small intestine, large intestine or rectum. They bring about many inconveniences in daily life in chr...
Gastrointestinal (GI) ailments cover a wide variety of diseases involving the esophagus, stomach, small intestine, large intestine or rectum. They bring about many inconveniences in daily life in chronic diseases and can even be life-threatening in acute cases. Rapid and safe detection approaches are essential for early diagnosis and timely managements. Contrast agent of GI imaging could enhance the contrast to distinguish the abnormal lesions from normal structures. CT and MRI are two important diagnostic tools for the evaluation of GI conditions. This review mainly involves several common GI diseases including inflammatory diseases, intestinal tumors, diarrhea, constipation and gastroesophageal reflux diseases. Selected contrast agents are summarized such as barium sulfate, iodine-based agents, gadolinium-based agents and others. Going forward, continued endeavors are being made to develop more emerging contrast agents for other imaging modalities.
- Quality of life in patients with loco-regional rectal cancer after ELRR by TEM versus VLS TME after nChRT: long-term results. [Journal Article]
- SESurg Endosc 2018 Nov 12
- CONCLUSIONS: In selected patients with rectal cancer, who underwent ELRR by TEM or LTME, QoL tests at 3 years do not show any statistical differences on examined items.
- Vestibular Evoked Myogenic Potentials Are Abnormal in Idiopathic REM Sleep Behavior Disorder. [Journal Article]
- FNFront Neurol 2018; 9:911
- Objectives: To investigate brainstem function in idiopathic REM sleep Behavior Disorder (iRBD), a condition occurring as a result of a derangement of connections within brainstem structures, with a ...
Objectives: To investigate brainstem function in idiopathic REM sleep Behavior Disorder (iRBD), a condition occurring as a result of a derangement of connections within brainstem structures, with a battery of Vestibular Evoked Myogenic Potentials (VEMPs), neurophysiological tools suited for the functional investigation of the brainstem. Neurophysiological data were correlated with clinical characteristics of patients. Methods: Twenty patients with iRBD and 22 healthy controls underwent cervical (cVEMP), masseter (mVEMP) and ocular (oVEMP) VEMP recording. Patients were assessed clinically according to presence of motor as well as non-motor symptoms such as constipation, depression, and hyposmia. Also, they were screened for postural instability through the Berg Balance Scale (BBS). VEMPs were categorized as for increasing degrees of abnormalities, namely latency delay, amplitude reduction and absence; a VEMP score was built accordingly. Results: Compared with controls, iRBD had higher rates of abnormalities both in the VEMP battery (iRBD 75%, Controls 23%; p < 0.01) as well as in each single VEMP (cVEMP: 45 vs. 5%; mVEMP: 65 vs. 13.6%; oVEMP: 50 vs. 5%; p < 0.01), which exhibited significantly lower amplitudes (cVEMP and oVEMP: p < 0.0001; mVEMP: p = 0.001) in iRBD. Within altered reflexes, absence was predominant in oVEMP (81%), amplitude reduction in mVEMP (50%) and cVEMP (70%). Severity of VEMP alterations was significantly higher in iRBD compared with controls (p < 0.05 for all VEMPs), as indicated by the larger VEMP scores in the former. The oVEMP score correlated inversely with poor performances on the BBS. Conclusion: VEMPs unveil consistent and extensive brainstem abnormalities in iRBD patients. Further studies are warranted for testing the potential of VEMPs in the monitoring of the evolution of iRBD over time.
- A Protocol-Driven Assessment Promotes a More Accurate Diagnosis of Irritable Bowel Syndrome. [Journal Article]
- GNGastroenterol Nurs 2018 Nov 08
- A diverse range of conditions share symptoms commonly identified with irritable bowel syndrome. The objective of this study was to examine the diagnostic process in identifying additional diagnoses i...
A diverse range of conditions share symptoms commonly identified with irritable bowel syndrome. The objective of this study was to examine the diagnostic process in identifying additional diagnoses in women who are attending a clinic for evaluation of symptoms suggestive of irritable bowel syndrome. A retrospective audit was conducted of anonymous data gathered on consecutive female patients presenting to a specialist nurse-led service in Christchurch, New Zealand, with a provisional diagnosis of irritable bowel syndrome. A protocol containing routine pathology investigations and physical examination was used. Alarm features were identified and pertinent investigations were implemented. Rectocele was detected on rectal examination. Final diagnosis was noted and compared with baseline symptom data. Of 231 patients, 187 initially met Rome III criteria for irritable bowel syndrome. Red flags and abnormal investigations led to an alternate diagnosis in a further 27 patients. Of the 160 patients with irritable bowel syndrome, 31% were found to have a rectocele. They were seven times more likely to report a symptom associated with pelvic floor dysfunction (p < .0001) and four times more likely to report constipation (p = .0003). The use of a protocol including routine investigations and physical examination improves diagnostic yield. Pelvic floor dysfunction should be considered in those with unique symptom patterns and rectocele in the setting of irritable bowel syndrome.
- Systematic review and meta-analysis: defecography should be a first-line diagnostic modality in patients with refractory constipation. [Review]
- APAliment Pharmacol Ther 2018 Nov 11
- CONCLUSIONS: Pathological structural abnormalities, as well as functional abnormalities, are common in patients with chronic constipation. Since structural abnormalities cannot be evaluated using nonimaging test modalities (balloon expulsion and anorectal manometry), defecography should be considered the first-line diagnostic test if resources allow.
- [Surgery for chronic constipation]. [Journal Article]
- NSNihon Shokakibyo Gakkai Zasshi 2018; 115(11):967-976
- [Pharmacological treatment of chronic constipation]. [Journal Article]
- NSNihon Shokakibyo Gakkai Zasshi 2018; 115(11):959-966
- [Diagnosis and pathophysiology of constipation]. [Journal Article]
- NSNihon Shokakibyo Gakkai Zasshi 2018; 115(11):950-958
- [Crucial role of microbiota in the pathogenesis of chronic constipation]. [Journal Article]
- NSNihon Shokakibyo Gakkai Zasshi 2018; 115(11):940-949
New Search Next
- [Novel perspectives in management of chronic constipation]. [Journal Article]
- NSNihon Shokakibyo Gakkai Zasshi 2018; 115(11):933-939