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Unbound Medicine.
(Cushing's ulcer)
55 results
  • Thrombin action on astrocytes in the hindbrain of the rat disrupts glycemic and respiratory control. [Journal Article]
    Am J Physiol Regul Integr Comp Physiol. 2020 Jun 01; 318(6):R1068-R1077.Rogers RC, Hasser EM, Hermann GE
  • Severe trauma can produce a postinjury "metabolic self-destruction" characterized by catabolic metabolism and hyperglycemia. The severity of the hyperglycemia is highly correlated with posttrauma morbidity and mortality. Although no mechanism has been posited to connect severe trauma with a loss of autonomic control over metabolism, traumatic injury causes other failures of autonomic function, no…
  • Intestinal Perforation in ACTH-Dependent Cushing's Syndrome. [Clinical Trial]
    Biomed Res Int. 2019; 2019:9721781.Shahidi M, Phillips RA, Chik CL
  • Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred more frequently in patients with ectopic ACTH syndrome and in those with a greater…
    Nihon Hinyokika Gakkai Zasshi. 2018; 109(3):164-168.Yamanaka Y, Kawashima A, … Nonomura N
  • A 64-year-old man was diagnosed as having Cushing's disease due to multiple lumbar compression fracture in 2009. Although various treatments including three times transsphenoidal surgery and twice radiotherapy were performed, his serum cortisol level rose again and intractable cutaneous ulcer occurred. Just after discontinuation of medication to treat the progression due of severe hepatic dysfunc…
  • Near-Fatal Gastrointestinal Hemorrhage in a Child with Medulloblastoma on High Dose Dexamethasone. [Case Reports]
    Cureus. 2017 Jul 07; 9(7):e1442.Yecies D, Tawfik D, … Damian M
  • A four-year-old female was admitted to a university-based children's hospital with a newly-diagnosed posterior fossa tumor. She was started on famotidine and high-dose dexamethasone and underwent gross total resection of a medulloblastoma. She was continued on dexamethasone and famotidine. She exhibited postoperative posterior fossa syndrome and was started on enteral feeds via the nasoduodenal t…
  • Ectopic adrenocorticotropic hormone syndrome caused by neuroendocrine carcinoma of the colon. [Case Reports]
    Nihon Shokakibyo Gakkai Zasshi. 2016; 113(10):1752-1760.Fujimoto K, Nakashima T, … Sano N
  • A 48-year-old woman with a history of autoimmune hemolytic anemia and taking long-term corticosteroid therapy presented with a 3-month history of general fatigue, abdominal distension, and pigmentation. A computed tomography scan of the abdomen showed a tumor in the sigmoid colon and multiple metastatic nodules in the liver. A colonoscopy revealed an obstructing mass with the presence of an irreg…
  • Cushing's ulcer: Further reflections. [Journal Article]
    Asian J Neurosurg. 2015 Apr-Jun; 10(2):87-94.Kemp WJ, Bashir A, … Cohen-Gadol AA
  • CONCLUSIONS: Harvey Cushing's pioneering work depicted in his Yale registry serves as a milestone for continuing research that can further discern this pathway.
  • Peptic ulcer disease in endogenous hypercortisolism: myth or reality? [Journal Article]
    Endocrine. 2015 Nov; 50(2):489-95.Hatipoglu E, Caglar AS, … Kadioglu P
  • Many clinicians believe hypercortisolism is ulcerogenic. However, data from clinical studies show that prophylaxis for peptic ulcer disease is no longer recommended in patients receiving corticosteroid treatment. This has not yet been verified in endogenous hypercortisolism by controlled clinical studies. The purpose of the current study was to evaluate the relationship between endogenous Cushing…
  • Cushing's ulcer: the eponym and his own. [Historical Article]
    Neurosurgery. 2011 Jun; 68(6):1695-8; discussion 1698.Wijdicks EF
  • One of the least remembered eponyms associated with Harvey Cushing is "Cushing's ulcer." The basis of this credit is a paper published in 1932 in which Cushing describes patients who postoperatively and unexpectedly died of perforated peptic ulcers. It is one of the first descriptions of a stress ulcer and a treatise on the brain-stomach connection. Harvey Cushing was puzzled by the pathogenesis …
  • Another 'Cushing ulcer'. [Case Reports]
    BMJ Case Rep. 2011 Apr 09; 2011Hoshino C, Satoh N, … Inoue M
  • The authors describe the case of a 39-year-old man who presented to our hospital with easy fatigability and malaise. On physical examination, hypertension was noted without any cushingoid appearance. Laboratory testing revealed normochromic-normocytic anaemia with positive results of occult blood in the stool, hyperglycaemia and hypokalemia. Upper endoscopy revealed active gastric ulcer with Heli…
  • Cushing's syndrome and chronic venous ulceration--a clinical challenge. [Case Reports]
    Int Wound J. 2011 Feb; 8(1):99-102.Biswas M, Gibby O, … Harding K
  • Cushing's syndrome is a condition caused by high levels of glucocorticoids, or most commonly as a result of prolonged exposure to exogenous steroids. Clinical features include diabetes, hypertension, obesity, skin atrophy, immune suppression and delayed wound healing. We report a patient with iatrogenic Cushing's syndrome, in whom long-term topical steroid therapy was used to treat varicose eczem…
  • Calcareous degeneration of the canine cornea. [Journal Article]
    Vet Ophthalmol. 2010 Jul; 13(4):238-43.Sansom J, Blunden T
  • The purpose of this paper is to describe a specific presentation of canine corneal calcification. Fourteen cases are described. In seven cases the corneal lesions were bilaterally symmetrical. In five cases the corneal lesion was unilateral. Two dogs were uniocular, the contralateral eye had been enucleated between 1 and 3 months previously by the referring veterinary surgeon following corneal ul…
  • Cushing's ulcer in traumatic brain injury. [Review]
    Chin J Traumatol. 2008 Apr; 11(2):114-9.Alain BB, Wang YJ
  • Traumatic brain injury (TBI) remains a complicated and urgent disease in our modernized cities. It becomes now a public health disease. We have got more and more patients in Neurosurgery Intensive Care Unit following motor vehicle accidents and others causes. TBI brings multiple disorders, from the primary injury to secondary injury. The body received the disturbances in the brain, in the hypotha…
  • Hypercalcemia in a dog with resolution of iatrogenic Cushing's syndrome. [Case Reports]
    J Vet Med Sci. 2004 Mar; 66(3):329-31.Nakamura M, Kawamura Y, … Iwasaki T
  • A six-year-old spayed Pug was presented with crust formation and ulcer on the skin. The patient had received long-term glucocorticoid therapy for treatment of tentatively diagnosed panniculitis. Severe calcification and pyoderma was observed and the patient was diagnosed with iatrogenic Cushing's syndrome and predonisolone was gradually withdrawn. After the withdrawal, the patient developed marke…
  • Association of depression with medical illness: does cortisol play a role? [Review]
    Biol Psychiatry. 2004 Jan 01; 55(1):1-9.Brown ES, Varghese FP, McEwen BS
  • Elevated cortisol in a subset of depressed patients is an enduring and well-replicated finding. Much interest has focused on the possible effects of depression on the hippocampus; however, an emerging body of evidence suggests an association between depression and non-central nervous system illnesses. In this review, data on the effects of depression on the brain and other organ systems sensitive…
  • Harvey Cushing at the Peter Bent Brigham Hospital. [Historical Article]
    Neurosurgery. 1999 Nov; 45(5):990-1001.Black PM
  • Harvey Cushing's years at the Peter Bent Brigham Hospital in Boston were marked by the establishment of neurosurgery as a surgical subspecialty. As a clinical neurosurgeon, he performed more than 2000 brain tumor operations in that time and reduced neurosurgical mortality from 50% to only 8%. As a teacher, he trained a whole generation of neurosurgical leaders, created the Society of Neurosurgeon…
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