Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(Cyclooxygenase 2 inhibitors)
16,209 results
  • Hereditary polyposis syndromes remain a challenging disease entity: Old dilemmas and new insights. [Review]
    World J Gastrointest Surg. 2023 Jan 27; 15(1):1-8.Pachler FR, Byrjalsen A, … Jelsig AM
  • In this editorial we present an overview and insights of the management of hereditary polyposis syndromes. The primary focus was on familial adenomatous polyposis, juvenile polyposis syndrome and Peutz-Jegher syndrome. Genetic testing has become increasingly available and is easier than ever to integrate into clinical practice. Furthermore, several genes have been added to the expanding list of g…
  • Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]
    Farm Hosp. 2023 Jan 27 [Online ahead of print]Ibarra Barrueta O, García Martín E, … Ais Larisgoitia A
  • CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
  • Etoricoxib Induced Toxic Epidermal Necrolysis in a case of Systemic Lupus Erythematosus: A Case Report. [Case Reports]
    JNMA J Nepal Med Assoc. 2022 Sep 01; 60(253):811-814.Pandey A, Parajuli S, … Dongol A
  • Toxic epidermal necrolysis is a potentially life-threatening dermatological condition whose pathogenesis and exact treatment are not yet known. Drugs like anticonvulsants, allopurinol and non-steroidal anti-inflammatory drugs like etoricoxib, a selective cyclo-oxygenase-2 inhibitor prescribed for pain management are associated with a high risk of toxic epidermal necrolysis. It is also associated …
  • Significance of Pulmonary Endothelial Injury and the Role of Cyclooxygenase-2 and Prostanoid Signaling. [Review]
    Bioengineering (Basel). 2023 Jan 14; 10(1)Nickl R, Hauser S, … Richter T
  • The endothelium plays a key role in the dynamic balance of hemodynamic, humoral and inflammatory processes in the human body. Its central importance and the resulting therapeutic concepts are the subject of ongoing research efforts and form the basis for the treatment of numerous diseases. The pulmonary endothelium is an essential component for the gas exchange in humans. Pulmonary endothelial dy…
  • Сyclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells. [Journal Article]
    Bull Exp Biol Med. 2022 Dec; 174(2):210-215.Li X, Zhou JX, … Kuang X
  • We studied the inhibitory effect of cyclooxygenase-2 inhibitor parecoxib on LPS-induced activation of BV2 microglia cells. The optimal dose of parecoxib (80 μmol/liter) was evaluated by the Cell Counting Kit-8. The cells were divided into the following groups: control (intact cells without treatment); LPS (treatment with 1 μg/ml LPS for 6 h), and experimental (pretreatment with 80 μmol/liter pare…
  • [Non-steroidal Anti-inflammatory Drugs and Cardiovascular Risk]. [Journal Article]
    Praxis (Bern 1994). 2023 Jan; 112(1):16-21.Schmied C
  • Non-steroidal Anti-inflammatory Drugs and Cardiovascular Risk Abstract. Non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most frequently used drugs worldwide, although medically controlled prescription is missing most of the time. Beside well-known gastro-intestinal and renal side effects, the potentially increased cardiovascular risk under NSAIDs remains underestimated. Nonselectiv…
  • Development of poly(lactide-co-glycolide) microparticles for sustained delivery of meloxicam. [Journal Article]
    J Control Release. 2023 Jan; 353:823-831.Pei Y, Wang J, … Yeo Y
  • Poly(lactide-co-glycolide) (PLGA) polymers have been widely used for drug delivery due to their biodegradability and biocompatibility. One of the objectives of encapsulating a drug in PLGA microparticles (MPs) is to achieve an extended supply of the drug through sustained release, which can range from weeks to months. Focusing on the applications needing a relatively short-term delivery, we inves…
  • Reflection-enhanced laser-induced fluorescence spectroscopy to improve the analytical sensitivity in liquids. [Journal Article]
    Spectrochim Acta A Mol Biomol Spectrosc. 2023 Mar 15; 289:122230.Abdel-Harith M, Abdel-Salam Z
  • The current work demonstrates a novel approach to enhancing the analytical sensitivity of the laser-induced fluorescence (LIF) technique in liquids. An increase in the fluorescence spectral band intensity of about sixfold compared to the conventional LIF has been achieved. Such betterment has been accomplished by having the fluorophore liquid in a cuvette having a reflecting mirror-like side faci…
  • Synthesis of New Ester Derivatives of Salicylic Acid and Evaluation of Their COX Inhibitory Potential. [Journal Article]
    Chem Biodivers. 2023 Jan; 20(1):e202200509.Koca M, Anıl B, … Özakar E
  • Salicylic acid is an NSAID with serious side effects on the GIS. The side effects of salicylic acid on the GIS are slightly reduced by acetylating salicylic acid. 12 new ester analogs of salicylic acid were synthesized with high yields in this study. The chemical structures of the synthesized compounds were characterized by 1 H-NMR, 13 C-NMR, and HRMS spectra. The inhibitory potential of the comp…
New Search Next