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12,332 results
  • Educational Case: Ductal Carcinoma In Situ (DCIS). [Journal Article]
    Acad Pathol 2019 Jan-Dec; 6:2374289519888727Komforti MK, Harmon BE
  • The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objective…
  • Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression. [Journal Article]
    EMBO Rep 2019; :e48741Kushner MH, Ory V, … Riegel AT
  • Transcription factors critical for the transition of normal breast epithelium to ductal carcinoma in situ (DCIS) and invasive breast cancer are not clearly defined. Here, we report that the expression of a subset of YAP-activated and YAP-repressed genes in normal mammary and early-stage breast cancer cells is dependent on the nuclear co-activator AIB1. Gene expression, sequential ChIP, and ChIP-s…
  • Grading Ductal Carcinoma In Situ (DCIS) of the Breast - What's Wrong with It? [Review]
    Pathol Oncol Res 2019Cserni G, Sejben A
  • Ductal carcinoma in situ of the breast is a non-obligate precursor of invasive breast cancer, and at its lower risk end might not need treatment, a hypothesis tested in several currently running randomized clinical trials. This review describes the heterogeneity of grading ductal carcinoma in situ (DCIS). First it considers differences between low and high grade DCIS, and then it looks at several…
  • Low-Grade Ductal Carcinoma In Situ. [Journal Article]
    Am J Clin Pathol 2019Alghamdi SA, Krishnamurthy K, … Gomez-Fernandez CR
  • CONCLUSIONS: Pathologists' reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance.
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