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25,472 results
  • Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives. [Journal Article]
    Eur J Med Chem. 2020 Jun 27; 202:112513.Mohammed AAM, Suaifan GARY, … Okechukwu PN
  • Herein we report the design, synthesis and biological evaluation of structurally modified ciprofloxacin, norfloxacin and moxifloxacin standard drugs, featuring amide functional groups at C-3 of the fluoroquinolone scaffold. In vitro antimicrobial testing against various Gram-positive bacteria, Gram-negative bacteria and fungi revealed potential antibacterial and antifungal activity. Hybrid compou…
  • Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions. [Journal Article]
    Fly (Austin). 2020 Jul 02 [Online ahead of print]Chen P, Visokay S, Abrams JM
  • Glutamine: fructose-6-phosphate amidotransferase (GFAT) enzymes catalyse the first committed step of the hexosamine biosynthesis pathway (HBP) using glutamine and fructose-6-phosphate to form glucosamine-6-phosphate (GlcN6P). Numerous species (e.g. mouse, rat, zebrafish, chicken) including humans and Drosophila encode two broadly expressed copies of this enzyme but whether these perform redundant…
  • Protein Modifications Critical for Myonectin/Erythroferrone Secretion and Oligomer Assembly. [Journal Article]
    Biochemistry. 2020 Jul 06 [Online ahead of print]Stewart AN, Little HC, … Wong GW
  • Myonectin/erythroferrone (also known as CTRP15) is a secreted hormone with metabolic function and a role in stress erythropoiesis. Despite its importance in physiologic processes, biochemical characterization of the protein is lacking. Here, we show that multiple protein modifications are critical for myonectin secretion and multimerization. Abolishing N-linked glycosylation by tunicamycin, gluco…
  • Machaerium acutifolium lectin alters membrane structure and induces ROS production in Candida parapsilosis. [Journal Article]
    Int J Biol Macromol. 2020 Jun 26 [Online ahead of print]Dias LP, Santos ALE, … Teixeira CS
  • Lectins are a group of widely distributed and structurally heterogeneous proteins of nonimmune origin. These proteins have the ability to interact with glycans present on cell surfaces and elicit diverse biological activities. Machaerium acutifolium lectin (MaL) is an N-acetyl-D-glucosamine-binding lectin that exhibits antinociceptive activity via transient receptor potential cation channel subfa…
  • [The clinical status and treatment options for osteoarthritis in patients with frailty]. [Journal Article]
    Ter Arkh. 2019 Dec 15; 91(12):135-141.Naumov AV, Khovasova NO, … Shavlovskaya OA
  • Aging is an independent risk factor for the development of many diseases and geriatric syndromes. Osteoarthritis (OA), as the most common joint disease in the elderly, can be attributed to age - associated conditions. And the most significant geriatric syndrome, which dramatically affects the management and prognosis of an elderly, is frailty. The review provides current information on the preval…
  • Semi-synthetic diversification of coronarin D, a labdane diterpene, under Ugi reaction conditions. [Journal Article]
    Nat Prod Res. 2020 Jun 25 [Online ahead of print]Veena KS, Taniya MS, … Lankalapalli RS
  • The prevalence of 5-hydroxydihydrofuran-2(3H)-one moiety in natural products is exploited for the first time using coronarin D, a labdane diterpene, to afford Ugi reaction product 1a and interrupted Ugi product 2a. The potential of the Ugi reaction was further extended to l-phenylalanine, 2-aminopyridine, and d-glucosamine, which afforded Ugi reaction products 3a-f, 4, and 5a-d, respectively. Cyt…
  • The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. [Journal Article]
    PLoS Genet. 2020 Jun 24; 16(6):e1008840.Alme EB, Stevenson E, … Toczyski DP
  • The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the carbohydrate precursor to protein glycosylation, GPI-anchor formation, and chitin biosynthesis. Overexpression of IS…
  • Acceptance and use of the Information System of the National Immunization Program. [Journal Article]
    Rev Lat Am Enfermagem. 2020; 28:e3307.Oliveira VC, Guimarães EAA, … Pinto IC
  • CONCLUSIONS: nursing professionals perceive advantages in the acceptance and use of the Information System of the National Immunization Program. It was clear that the vaccinated individual's history control and the decrease of records in paper are evidenced as facilitators of this acceptance. The system was considered reliable and secure.
  • Larvicidal effect from different Annonaceae species on Culex quinquefasciatus. [Journal Article]
    Environ Sci Pollut Res Int. 2020 Jun 23 [Online ahead of print]Maia DS, Lopes CF, … de Siqueira JM
  • The recent outbreaks of mosquito-borne diseases highlighted the pivotal importance of mosquito vector control in tropical areas worldwide. Several strategies have been developed to control vector populations and disease transmission in endemic areas. The steps to obtain natural active compounds involve the pre-selection in a biological model and subsequently evaluation on specific models. The pre…
  • Absorption of glucosamine is improved by considering circadian rhythm and feeding time in rats. [Journal Article]
    Chronobiol Int. 2020 Jun 24 [Online ahead of print]Seto Y, Yoshihashi T, … To H
  • Although many basic and clinical studies have shown that glucosamine (GlcN) improves osteoarthritis, it has not been widely used in the clinic because its bioavailability is only 6%. We investigated the influence of dosing-time factors, which influence pharmacokinetics and food intake in rats to improve its bioavailability. When GlcN was orally administered to rats housed under conditions of free…
  • Identification of longevity compounds with minimized probabilities of side effects. [Journal Article]
    Biogerontology. 2020 Jun 19 [Online ahead of print]Janssens GE, Houtkooper RH
  • It is hypothesized that treating the general aging population with compounds that slow aging, geroprotectors, could provide many benefits to society, including a reduction of age-related diseases. It is intuitive that such compounds should cause minimal side effects, since they would be distributed to otherwise healthy individuals for extended periods of time. The question therefore emerges of ho…
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