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24,812 results
  • Categories and biomanufacturing methods of glucosamine. [Review]
    Appl Microbiol Biotechnol 2019Ma Q, Gao X
  • Glucosamine (GlcN) is an amine sugar, in which a hydroxyl group of glucose is replaced with an amino group. It is an important part of the polysaccharides chitin and chitosan and is highly hydrophilic. It is also an important compound required for the formation of cartilage cells and represents one of the elementary units of the cartilage matrix and joint fluid. GlcN has been widely used in food,…
  • Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. [Journal Article]
    ACS Chem Biol 2019Furuta T, Mizukami Y, … Uesugi M
  • Covalent conjugates of multiple nutrients often exhibit greater biological activities than each individual nutrient and more predictable safety profiles than completely unnatural chemical entities. Here we report the construction and application of a focused chemical library of 308 covalent conjugates of a variety of small-molecule nutrients. Screening of the library with a reporter gene of stero…
  • Application of Chitosan in Bone and Dental Engineering. [Review]
    Molecules 2019; 24(16)Aguilar A, Zein N, … Hua G
  • Chitosan is a deacetylated polysaccharide from chitin, the natural biopolymer primarily found in shells of marine crustaceans and fungi cell walls. Upon deacetylation, the protonation of free amino groups of the d-glucosamine residues of chitosan turns it into a polycation, which can easily interact with DNA, proteins, lipids, or negatively charged synthetic polymers. This positive-charged charac…
  • Differential Recognition of Deacetylated PNAG Oligosaccharides by a Biofilm Degrading Glycosidase. [Journal Article]
    ACS Chem Biol 2019Wang S, Breslawec AP, … Poulin MB
  • Exopolysaccharides consisting of partially de-N-acetylated poly-β-D-(1→6)-N-acetyl-glucosamine (dPNAG) are key structural components of the biofilm extracellular polymeric substance of both gram-positive and gram-negative human pathogens. De-N-acetylation is required for the proper assembly and function of dPNAG in biofilm development suggesting that different patterns of deacetylation may be pre…
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