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(DOPamine)
161,211 results
  • Repurposing Antipsychotics of the Diphenylbutylpiperidine Class for Cancer Therapy. [Review]
    Semin Cancer Biol 2019Shaw V, Srivastava S, Srivastava SK
  • The recent development of high throughput compound screening has allowed drug repurposing to emerge as an effective avenue for discovering novel treatments for cancer. FDA-approved antipsychotic drugs fluspirilene, penfluridol, and pimozide are clinically used for the treatment of psychotic disorders, primarily schizophrenia. These compounds, belong to diphenylbutylpiperidine class of antipsychot…
  • Cytokines and nervous system: relationship with schizophrenia [Journal Article]
    Rev Med Inst Mex Seguro Soc 2019; 57(2):107-112Ramírez-Jirano LJ, Velasco-Ramírez SF, … Bitzer-Quintero OK
  • Schizophrenia is a heterogeneous disorder of mental symptoms and alterations, characterized by presenting abnormal ideas and perceptions, in which the individual loses contact with reality as a result of a complex neuropsychological disorganization, which affects the affective, intellectual and behavioral functioning; as well as inducing a significant social dysfunction.The etiology of schizophre…
  • Aggressive prolactinomas: how to manage? [Review]
    Pituitary 2019Lasolle H, Ilie MD, Raverot G
  • CONCLUSIONS: Despite the significant improvement obtained with the use of temozolomide, a need for alternative drugs persists since a majority of these tumors are resistant or will recur during the follow-up. Patients suffering from such a rare condition should have access to clinical trials available for other types of rare cancers, such as tyrosine kinase inhibitors or immunotherapy.
  • The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales. [Journal Article]
    PeerJ 2019; 7:e7758Alves LQ, Alves J, … Castro F
  • To compare gene loci considering a phylogenetic framework is a promising approach to uncover the genetic basis of human diseases. Imbalance of dopaminergic systems is suspected to underlie some emerging neurological disorders. The physiological functions of dopamine are transduced via G-protein-coupled receptors, including DRD5 which displays a relatively higher affinity toward dopamine. Importan…
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