- Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy. [Journal Article]
- IOInvest Ophthalmol Vis Sci 2019 Jul 01; 60(8):3119-3126
- CONCLUSIONS: This study demonstrates that arginine and citrulline-related pathways are dysregulated in DR, and fatty acid metabolism is altered in PDR patients compared with NPDR patients.
- Can social media intervention improve physical activity of medical students? [Journal Article]
- PHPublic Health 2019 Jul 16; 174:69-73
- CONCLUSIONS: Social media are shown to be valuable in health-promoting interventions and can be used for interventions targeting lifestyle change among young adults.
- Surgery for spontaneous intracerebral hemorrhage - A comparative study with medical management in moderate to large sized hematomas. [Journal Article]
- CNClin Neurol Neurosurg 2019 Jul 11; 184:105415
- CONCLUSIONS: Surgical Evacuation of spontaneous intracerebral haemorrhage has a survival advantage at 90 days in moderate to large sized hematomas. It, however, did not demonstrate any quantifiable improvement in functional outcome. Surgical evacuation of moderate-sized hematomas reduces mortality caused by delayed perihematomal oedema.
- Analysis of chromophores in stained-glass windows using Visible Hyperspectral Imaging in-situ. [Journal Article]
- SASpectrochim Acta A Mol Biomol Spectrosc 2019 Jul 09; 223:117378
- This work presents the implementation of Visible Hyperspectral Imaging for the in-situ analysis of glass chromophores in two glass windows from the Casa-Museu Dr. Anastácio Gonçalves (Lisbon, Portuga…
This work presents the implementation of Visible Hyperspectral Imaging for the in-situ analysis of glass chromophores in two glass windows from the Casa-Museu Dr. Anastácio Gonçalves (Lisbon, Portugal). The measurements were taken inside the building using natural sunlight as the illumination source. In addition, advantages and disadvantages of the followed methodology are discussed. The Dining Room glass window presents glasses colored in bulk with iron, manganese, cobalt, copper, and chromium; silver staining was also detected and was used to create the yellow and orange colors. The Atelier panel was produced with uncolored glasses painted with grisaille and enamels; the chromophores identified are similar to the species identified in the Dining Room panel.
- Activation of Necroptosis by Engineered Self Tumor-Derived Exosomes Loaded with CRISPR/Cas9. [Letter]
- MTMol Ther Nucleic Acids 2019 Jul 03; 17:448-451
- CRISPR/Cas9 has proved its efficiency in vitro, where we now know that this tool can efficiently target specific parts of the genome. These modifications can be used to generate advanced models of hu…
CRISPR/Cas9 has proved its efficiency in vitro, where we now know that this tool can efficiently target specific parts of the genome. These modifications can be used to generate advanced models of human diseases, address specific functions of genes, and develop new therapeutic strategies. Even if these advancements are promising, there are still two great issues associated with CRISPR/Cas9: how we can specifically and safely deliver the editing tool in vivo and how we can address the impossibility of CRISPR/Cas9 to attack all the cells within the targeted pool? This work presents an alternative method for engagement of cell death in cancer cells with immediate application in the preclinical sector and significant translational relevance toward clinics.
- Sustainable hydrogen production for the greener environment by quantum dots-based efficient photocatalysts: A review. [Review]
- JEJ Environ Manage 2019 Jul 16; 248:109246
- Nano-size photocatalysts exhibit multifunctional properties that opened the door for improved efficiency in energy, environment, and health care applications. Among the diversity of catalyst Quantum …
Nano-size photocatalysts exhibit multifunctional properties that opened the door for improved efficiency in energy, environment, and health care applications. Among the diversity of catalyst Quantum dots are a class of nanomaterials having a particle size between 2 and 10 nm, showing unique optoelectrical properties that are limited to some of the metal, metal oxide, metal chalcogenides, and carbon-based nanostructures. These unique characteristics arise from either pristine or binary/ternary composites where noble metal/metal oxide/metal chalcogenide/carbon quantum dots are anchored on the surface of semiconductor photocatalyst. It emphasized that properties, as well as performance of photocatalytic materials, are greatly influenced by the choice of synthesis methods and experimental conditions. Among the chemical methods, photo-deposition, precipitation, and chemical reduction, are the three most influential synthesis approaches. Further, two types of quantum dots namely metal based and carbon-based materials have been highlighted. Based on the optical, electrical and surface properties, quantum dots based photocatalysts have been divided into three categories namely (a) photocatalyst (b) co-catalyst and (c) photo-sensitizer. They showed enhanced photocatalytic performance for hydrogen production under visible/UV-visible light irradiation. Often, pristine metal chalcogenides as well as metal/metal oxide/carbon quantum dots attached to a semiconductor particle exhibit enhanced the photocatalytic activity for hydrogen production through absorption of visible light. Alternatively, noble metal quantum dots, which provide plenty of defects/active sites facilitate continuous hydrogen production. For instance, production of hydrogen in the presence of sacrificial agents using metal chalcogenides, metal oxides, and coinage metals based catalysts such as CdS/MoS2 (99,000 μmol h-1g-1) TiO2-Ni(OH)2 (47,195 μmol h-1g-1) and Cu/Ag-TiO2 nanotubes (56,167 μmol h-1g-1) have been reported. Among the carbon-based nanostructures, graphitic C3N4 and carbon quantum dots composites displayed enhanced hydrogen gas (116.1 μmol h-1) production via overall water splitting. This review accounts recent findings on various chemical approaches used for quantum dots synthesis and their improved materials properties leading to enhanced hydrogen production particularly under visible light irradiation. Finally, the avenue to improve quantum efficiency further is proposed.
- Nanotechnology-based siRNA Delivery Strategies for Metastatic Colorectal Cancer Therapy. [Review]
- IJInt J Pharm 2019 Jul 16; :118530
- Colorectal cancer (CRC) is the second most common cause of cancer-related death in the world, mainly due to distant metastases events. The metastatic CRC (mCRC) stages are resistant to the therapeuti…
Colorectal cancer (CRC) is the second most common cause of cancer-related death in the world, mainly due to distant metastases events. The metastatic CRC (mCRC) stages are resistant to the therapeutic recommended. Therefore, it urges the development of more efficient strategies to impair the disease. Small interfering RNA (siRNA) is a well-known silencing tool with impact on targeted cancer therapy, even though in vivo challenges difficult its clinical application. Here, multiple solutions to overcome the extracellular and intracellular barriers encountered by intravenous delivery of siRNA are discussed. Moreover, it is emphasized the association of siRNA with nanoparticles to enable the long-term release and to counteract the toxicity issues of siRNA. Particular attention is paid on the potential of poly(lactic-co-glycolic acid) (PLGA) nanoparticles for systemic siRNA delivery in mCRC. Despite of being less used so far due to technological difficulties, multiple strategies to successfully encapsulate siRNA into PLGA nanocarriers are summarized.
- Bacterial endophytes from Artemisia nilagirica (Clarke) Pamp., with antibacterial efficacy against human pathogens. [Journal Article]
- MPMicrob Pathog 2019 Jul 16; :103624
- A study was conducted to isolate and characterize endophytes from Artemisia nilagirica, a traditional medicinal plant. The plant was collected from Western Ghats, India. Endophytes isolated included …
A study was conducted to isolate and characterize endophytes from Artemisia nilagirica, a traditional medicinal plant. The plant was collected from Western Ghats, India. Endophytes isolated included Arthrobacter sp. WWAT1, Pseudomonas sp. WYAT2, Microbacterium sp. WYAT3, Psychrobacter sp. WBAT4, Enterobacter sp. WWAT5, Bacillus sp. WBAT6, Kosakonia cowanii WBAT7, Bacillus sp. WBAT8, Bacillus sp. WBAT9, Chromobacterium violaceum WVAT6, Serratia sp.WPAT8 and Burkholderia sp. WYAT7. Of these two bacteria, Chromobacterium violaceum strain WVAT6 and Burkholderia sp. strain WYAT exhibited antibacterial property against human pathogens. Similar to the environmental isolates, Burkholderia sp. WYAT7 showed pleomorphism and produced different enzymes, whereas like clinical strains they showed multidrug resistance, for their survival in different environmental conditions. Chromobacterium violaceum WVAT6 exhibited rod shape morphology and showed multiple drug resistance except to erythromycin, tetracycline and gentamicin antibiotics. Both produced biofilm and enzymes such as protease and lipase. The antimicrobial compounds from these endophytes may find application in the preparation of antimicrobial formulations.
- Upregulation of the nitrosylome in bipolar disorder type 1 (BP1) and major depression, but not BP2: Increased IgM antibodies to nitrosylated conjugates are associated with indicants of leaky gut. [Journal Article]
- NONitric Oxide 2019 Jul 16
- CONCLUSIONS: BP1 and MDD are characterized by an upregulation of the nitrosylome (the proteome of nitrosylated proteins) and increased IgM responses to nitrosylated conjugates. Increased nitrosylation may be driven by increased bacterial translocation and is associated with lipid peroxidation processes. Innate-like (B1 and marginal zone) B cells and increased nitrosylation may play a key role in the major affective disorders through activation of immune-inflammatory and oxidative pathways, cardiovascular comorbidity and impairments in antioxidant defenses, neuro-glial interactions, synaptic plasticity, neuroprotection, neurogenesis.
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- Noninvasive characterization of In Situ forming implant diffusivity using diffusion-weighted MRI. [Journal Article]
- JCJ Control Release 2019 Jul 16
- In situ forming implants (ISFIs) form a solid drug-eluting depot, releasing drug for an extended period of time after a minimally-invasive injection. Clinical use of ISFIs has been limited because ma…
In situ forming implants (ISFIs) form a solid drug-eluting depot, releasing drug for an extended period of time after a minimally-invasive injection. Clinical use of ISFIs has been limited because many factors affect drug release kinetics. The aim of this study was to use diffusion-weighted MRI (DWI) to noninvasively quantify spatial-temporal changes in implant diffusivity in situ. ISFIs were formed using poly(lactic-co-glycolic) acid, with a molecular weight of either 15 kDa or 52 kDa, and fluorescein as the mock drug. Drug release, polymer erosion and degradation, and implant diffusivity were analyzed in vitro over 21 days. DWI was also performed in vivo over 5 days. Spatial diffusivity maps of the implant were generated using DWI data. Results showed constant diffusivity at the implant shell ((1.17 ± 0.128) × 10-3 mm2/s) and increasing diffusivity within the interior over time (from (0.268 ± 0.0813) × 10-3 mm2/s during day 1 to (1.88 ± 0.0400) × 10-3 mm2/s at 14 d), which correlated with increasing porosity of the implant microstructure. Implants formed in vivo followed the same diffusivity trend as those in vitro. This study validates the use of DWI to provide novel functional information about implant behavior through its ability to noninvasively characterize transport properties within the implant both in vitro and in vivo.