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Unbound Medicine.
(Depression)
600,744 results
  • The rapid anxiety screening study-pilot data. [Journal Article]
    J Investig Med. 2023 Feb 08 [Online ahead of print]Kandel S, Delgado E, … Ayala J
  • Anxiety disorders are the most common mental health condition in the United States. Medical providers often have many active issues when treating a patient, and do not always have time for a thorough psychiatric evaluation. The Patient Health Questionnaire 2, a two-question binary (yes/no) screening tool, has been developed to address these issues in the identification of unipolar depression. No …
  • Cognitive performance and brain structural connectome alterations in major depressive disorder. [Journal Article]
    Psychol Med. 2023 Feb 08 [Online ahead of print]Gruber M, Mauritz M, … Repple J
  • CONCLUSIONS: Our study is the first to identify cognition-related structural brain networks in MDD patients, thereby revealing associations between cognitive deficits, depressive symptoms, and reduced structural connectivity. This supports the hypothesis that structural connectome alterations may mediate the association of cognitive deficits and depression severity.
  • [Depressive Disorders in Adolescence: Current State of Studies Concerning the Microbiota-Gut-Brain Axis]. [Review]
    Z Kinder Jugendpsychiatr Psychother. 2023 Feb 08 [Online ahead of print]Kandsperger S, Brunner R, … Baghai TC
  • Depressive Disorders in Adolescence: Current State of Studies Concerning the Microbiota-Gut-Brain Axis Abstract. Depressive disorders increase during adolescence and often lead to significant impairment in affected individuals - despite treatment. Current research efforts aim to further investigate the pathophysiology of depression, considering the influence of gut microbiota on the gut-brain axi…
  • Loneliness-a clinical primer. [Journal Article]
    Br Med Bull. 2023 Feb 07 [Online ahead of print]Lederman Z
  • CONCLUSIONS: due to increased individualization and incidence of infectious diseases, loneliness is likely to become even more prevalent.more research is needed to further elucidate the health impacts of loneliness as well as to find evidence-based interventions to prevent and mitigate loneliness that could then be implemented by policy-makers and clinicians.
  • Baseline characteristics of the North American prodromal Synucleinopathy cohort. [Journal Article]
    Ann Clin Transl Neurol. 2023 Feb 08 [Online ahead of print]Elliott JE, Lim MM, … North American Prodromal Synucleinopathy (NAPS) Consortium
  • CONCLUSIONS: These RBD participants, assessed with extensive history, demographic, cognitive, motor, sensory, and autonomic function demonstrated a lack of sex differences and high frequency of concomitant neurological abnormalities. These participants will be valuable for future longitudinal study and neuroprotective clinical trials.
  • Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder. [Journal Article]
    Neural Regen Res. 2023 Aug; 18(8):1795-1801.Li XH, Zhu HC, … Duan DX
  • We previously showed that death-associated protein kinase 1 (DAPK1) expression is increased in hippocampal tissue in a mouse model of major depressive disorde and is related to cognitive dysfunction in Alzheimer's disease. In addition, depression is a risk factor for developing Alzheimer's disease, as well as an early clinical manifestation of Alzheimer's disease. Meanwhile, cognitive dysfunction…
  • Splenectomy does not affect mouse behaviors. [Journal Article]
    Neural Regen Res. 2023 Aug; 18(8):1789-1794.Guan JQ, Zhang PS, … Yuan TF
  • The spleen is critical for immunity. It is the largest immune organ and immune center in the peripheral system. While the relationship between behavior and immunity has been demonstrated in physiology and diseases, the role of the spleen in behavior is not clear. To investigate the effects of the spleen on behaviors, we performed a refined splenectomy procedure on C57BL/6J mice and performed an o…
  • Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice. [Journal Article]
    Neural Regen Res. 2023 Aug; 18(8):1763-1769.Yang LX, Yao YY, … Zhang ZJ
  • Destruction of the blood-brain barrier is a critical component of epilepsy pathology. Several studies have demonstrated that sphingosine 1-phosphate receptor 1 contributes to the modulation of vascular integrity. However, its effect on blood-brain barrier permeability in epileptic mice remains unclear. In this study, we prepared pilocarpine-induced status epilepticus models and pentylenetetrazol-…
  • Complex psychiatric comorbidities in Thai trans women: A case series. [Case Reports]
    F1000Res. 2022; 11:74.Wainipitapong S, Burakitpachai S, Bumphenkiatikul T
  • Trans women (TW) have a high prevalence of poor mental health. Gender-affirming treatments could reduce distress regarding their gender incongruity. However, psychiatric comorbidities might complicate the management or even confirmation of being transgender. We reported three TW with complex mental illnesses, including anxiety disorder with cultural explanation, neurodevelopmental disorders with …
  • Acceptance and commitment therapy for people with acquired brain injury: Rationale and description of the BrainACT treatment. [Journal Article]
    Clin Rehabil. 2023 Feb 07 [Online ahead of print]Rauwenhoff JCC, Bol Y, … Peeters F
  • CONCLUSIONS: Existing evidence-based protocols were adapted for the needs and potential cognitive deficits after brain injury. General alterations are the use of visual materials, summaries and repetition. Acceptance and commitment therapy-specific adaptions include the Bus of Life metaphor as a recurrent exercise, shorter mindfulness exercises, simplified explanations, a focus on experiential exercises and the monitoring of committed actions. The intervention consists of eight one-hour sessions with a psychologist, experienced in acceptance and commitment therapy and in working with people with acquired brain injury. The order of the sessions, metaphors and exercises can be tailored to the needs of the patients.Currently, the effectiveness and feasibility of the intervention is evaluated in a randomised controlled trial. The BrainACT intervention is expected to be a feasible and effective intervention for people with anxiety or depressive symptoms following acquired brain injury.
  • Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases. [Review]
    Infect Agent Cancer. 2023 Feb 07; 18(1):7.Gottschalk CG, Peterson D, … Roy A
  • Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze human civilization's economy and social growth, leaving an enduring damage that will take an exceptionally long time to repair. While a majority of infected patients survive after mild …
  • Facilitators and barriers in the development and implementation of depression prevention and treatment policies in China: a qualitative study. [Journal Article]
    BMC Public Health. 2023 Feb 07; 23(1):276.Ma J, Zhou H, … Lu G
  • CONCLUSIONS: Although the process of implementing a distinctive service programme for depression prevention and treatment in China has been long, the current policy is in line with current global efforts. Strategies to reduce Stigma and increase knowledge about depression are part of a national and international approach to reducing the burden of depression. Political commitment and the involvement of all stakeholders remain necessary. An adequate response to depression will require the involvement of society as a whole, with joint action to reduce the risk of exposure to adversity and enhance protective factors.
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