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Unbound Medicine.
(Dercum disease)
201 results
  • Exophytic Adiposis Dolorosa (Dercum's Disease) of the Thigh: A Case Report. [Case Reports]
    Cureus. 2020 Mar 15; 12(3):e7282.Opoku-Agyeman JL, Coffua L, … Behnam A
  • Adiposis dolorosa or Dercum's disease is a rare lipomatous disorder characterized by painful lipomas. In this article, we report a case of rather large exophytic adiposis dolorosa causing difficulties with ambulation, and our surgical management of the disorder. To our knowledge, this is the first reported case of a large exophytic adiposis dolorosa of the upper medial thigh causing problems with…
  • Angiosarcoma arising in massive localized lymphedema. [Journal Article]
    Skeletal Radiol. 2020 May; 49(5):815-818.Dyroff S, Layfield LJ, Crim J
  • We report a case of a 70-year-old woman with a BMI of 58 who developed cellulitis refractory to treatment, within an area of massive localized lymphedema. Biopsy showed angiosarcoma. MRI showed multiple lobulated, low T1, high T2 masses within a background of prominent soft tissue septal stranding, dilated lymphatic channels, and skin thickening. CT also showed the mass well, within the backgroun…
  • Infections preceding the development of Dercum disease. [Case Reports]
    IDCases. 2020; 19:e00682.Beltran K, Wadeea R, Herbst KL
  • Dercum Disease (DD) is a rare inflammatory disease of painful subcutaneous fat masses with known alterations in lymphatic vessels. DD masses vary from pearl to walnut-size or larger and occur anywhere in body fat. Signs and symptoms of DD are similar to fibromyalgia. While the etiology of DD is unknown, metabolic, autoimmune, or autosomal genetic transmission has been proposed. This series presen…
  • Adiposis Dolorosa Pain Management. [Journal Article]
    Fed Pract. 2019 Nov; 36(11):529-533.Eliason AH, Seo YI, … Beal C
  • While current approaches to treatment focus on surgery, opiates, and other medications, health care providers may also consider ketamine infusion, electrostimulation, and perineural injections.
  • Dercum's disease (adiposis dolorosa): a review of clinical presentation and management. [Review]
    Reumatologia. 2019; 57(5):281-287.Kucharz EJ, Kopeć-Mędrek M, … Kotyla P
  • Dercum's disease (adiposis dolorosa) is a rare disease of unknown etiology characterized by painful subcutaneous adipose tissue deposits with various localization over the body. The deposits occur histologically as lipomas and are associated with overweight or obesity and a variety of psychiatric disturbances (anxiety, depression, sleep disturbances). Classification of Dercum's disease is related…
  • Genetic syndromes with localized subcutaneous fat tissue accumulation. [Journal Article]
    Acta Biomed. 2019 09 30; 90(10-S):90-92.Precone V, Barati S, … Bertelli M
  • Syndromes with localized accumulation of subcutaneous fatty tissue belong to a group of genetically and phenotypically heterogeneous disorders. These diseases may show some common signs, such as nodular fat, symmetrical fat masses, obesity, fatigue, lymphedema and symmetrical lipomas (painful or otherwise). Other symptoms may be specific for the different clinical entities, enabling correct diffe…
  • Lipedema and Dercum's Disease: A New Application of Bioimpedance. [Journal Article]
    Lymphat Res Biol. 2019 12; 17(6):671-679.Crescenzi R, Donahue PMC, … Herbst KL
  • CONCLUSIONS: BIS is a noninvasive portable modality to assess tissue water, and this device is available in both specialized and nonspecialized centers. These findings support that regional bioimpedance measures may help to distinguish lipedema from DD, as well as to identify early stages of lipedema.
  • [Dercum's disease]. [Journal Article]
    Ugeskr Laeger. 2019 May 27; 181(22)Day DL, Lauritzen E, … Petersen RB
  • Dercum's disease is a rare disease, which mainly affects women and has an unknown prevalence and aetiology. The disease is characterised by generalised obesity and more than three-month painful subcutaneous adipose tissue not responding to usual pain treatment. A suggested classi-fication of the disease includes four types: generalised diffuse, generalised nodular, localised nodular and juxta-art…
  • Intravenous Lidocaine for Acute Pain: A Systematic Review. [Case Reports]
    Pharmacotherapy. 2018 12; 38(12):1250-1259.Masic D, Liang E, … Rech MA
  • This systematic review evaluates the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patients. The PubMed database was searched for randomized controlled trials, retrospective cohort studies, case series, and case reports evaluating the use of IV lidocaine for the treatment of acute pain in adult patients, published between January 1970 and January 2018.…
  • StatPearls: Adiposis Dolorosa (Dercum, Anders Disease) [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Cook Jordan C. JC LewisGale Hospital Montgomery Gross Gary P. GP Lewis Gale Hospital Montgomery BOOK
  • Adiposis dolorosa is a rare disorder of multiple painful subcutaneous growths of adipose tissue. It is also known as Dercum disease, Ander syndrome, morbus Dercum, adipose tissue rheumatism, adiposalgia, or lipomatosis dolorosa. This disease was first discovered in the late 1800s by American neurologist Francis Xavier Dercum. It is classified into 4 types which include generalized diffuse, genera…
  • Trauma-induced adiposis dolorosa (Dercum's disease). [Case Reports]
    BMJ Case Rep. 2018 Mar 28; 2018Hao D, Olugbodi A, … Donato AA
  • We present a case of a 39-year-old man who presented with chronic bilateral upper extremity pain associated with innumerable angiomyolipomas that developed 5 years after a motor vehicle accident involving his upper extremities. Our case notes the rare nature of painful adipose tissue deposits and the diagnostic challenges.
  • StatPearls: Lipomas, Pathology [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Charifa Ahmad A Yale School of Medicine Badri Talel T University of Tunis El Manar BOOK
  • Lipomas are defined as soft masses of adipose (fat) cells which are often encapsulated by a thin layer of fibrous tissue. Clinically, they often present in the cephalic part of the body, specifically in the head, neck, shoulders, and backs of patients, although they can less commonly be seen elsewhere, for example, the thighs. The tumors typically lie in the subcutaneous tissues of patients. The …
  • Lipomatoses. [Review]
    J Dtsch Dermatol Ges. 2018 Mar; 16(3):313-327.Al Ghazal P, Grönemeyer LL, Schön MP
  • Lipomatoses are benign proliferations of adipose tissue, often with typical distribution patterns, which usually occur without clear causes. In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule. The most common form is benign symmetric lipomatosis (BSL; Launois-Bensaude syndrome), of which four types are distinguished bas…
  • Cutaneous manifestations of obesity and themetabolic syndrome. [Review]
    Clin Dermatol. 2018 Jan - Feb; 36(1):81-88.Uzuncakmak TK, Akdeniz N, Karadag AS
  • The cutaneous manifestations of obesity and the associated metabolic syndrome (MetS) may present with a wide variety of cutaneous findings, including acanthosis nigricans, acrochordon, cellulitis, psoriasis, hidradenitis suppurativa, acne, and hirsutism. Being aware of such clinical signs and the underlying systemic disorders may facilitate earlier diagnoses, thereby permitting earlier of therapy…
  • Differentiating lipedema and Dercum's disease. [Journal Article]
    Int J Obes (Lond). 2017 02; 41(2):240-245.Beltran K, Herbst KL
  • CONCLUSIONS: The significantly lower prevalence of DM2 in people with lipedema compared with DD may be due to the greater amount of gynoid fat known to be protective against metabolic disorders. The high percentage of hypermobility in lipedema patients indicates that it may be a comorbid condition. The location of fat, high average daily pain, presence of lipomas and comorbid painful disorders in DD patients may help differentiate from lipedema.
  • Lipedema: A Relatively Common Disease with Extremely Common Misconceptions. [Journal Article]
    Plast Reconstr Surg Glob Open. 2016 Sep; 4(9):e1043.Buck DW, Herbst KL
  • Lipedema, or adiposis dolorosa, is a common adipose tissue disorder that is believed to affect nearly 11% of adult women worldwide. It is characterized most commonly by disproportionate adipocyte hypertrophy of the lower extremities, significant tenderness to palpation, and a failure to respond to extreme weight loss modalities. Women with lipedema report a rapid growth of the lipedema subcutaneo…
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