- Significant Improvement in Blood Pressure Levels Among Older Adults With Hypertension in Rural South Africa. [Journal Article]Hypertension. 2023 Feb 08 [Online ahead of print]H
- CONCLUSIONS: The hypertension prevalence and incidence are plateauing in this aging cohort. There was a statistically and clinically significant decline in mean blood pressure and a substantial increase in individuals with controlled hypertension on medication. The prevalence of cardiometabolic risk factors did not decrease over time, suggesting that the blood pressure decrease is likely due to increased medication access and adherence, promoted by local health systems.
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- Psychosocial Factors Predict Medication Adherence in Young Adults with Youth-Onset Type 2 Diabetes: Longitudinal Results from the TODAY2 iCount Study. [Journal Article]Diabet Med. 2023 Feb 08 [Online ahead of print]DM
- CONCLUSIONS: Sub-optimal medication adherence, common in young adults with youth-onset type 2 diabetes, is predicted by interfering beliefs about medicines and social factors. We must address these beliefs and unmet needs to develop tailored interventions for this vulnerable group.
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- Serum testosterone and sex hormone-binding globulin are inversely associated with leucocyte telomere length in men: a cross-sectional analysis of the UK Biobank Study. [Journal Article]Eur J Endocrinol. 2023 Feb 08 [Online ahead of print]EJ
- CONCLUSIONS: Total testosterone and SHBG were independently and inversely associated with LTL. Men with higher testosterone or SHBG had shorter telomeres, arguing against a role for testosterone to slow biological ageing in men.
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- Pharmacological treatment of bipolar disorder and risk of diabetes mellitus: A nationwide study of 30,451 patients. [Journal Article]Bipolar Disord. 2023 Feb 08 [Online ahead of print]BD
- CONCLUSIONS: Treatment with valproate and antipsychotics-but not with lithium and lamotrigine-was associated with increased risk of DM in a real-world cohort of patients with bipolar disorder.
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- One year real-world performance of the DBLG1 closed-loop system: Data from 3706 adult users with type 1 diabetes in Germany. [Journal Article]Diabetes Obes Metab. 2023 Feb 08 [Online ahead of print]DO
- CONCLUSIONS: This large real-world analysis confirms the relevance of the DBLG1 automated insulin delivery solution for the achievement of standards of care in adult patients with type 1 diabetes. This article is protected by copyright. All rights reserved.
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- Prediabetes and the risk of type 2 diabetes: investigating the roles of depressive and anxiety symptoms in the Lifelines Cohort Study. [Journal Article]Diabet Med. 2023 Feb 08 [Online ahead of print]DM
- CONCLUSIONS: Individuals with elevated depressive, and to some extent anxiety, symptoms in combination with prediabetes may represent a high-risk subgroup for type 2 diabetes.
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- "It is in our hands-why wait until you are sick?": Perceptions about diabetes prevention of Latina mothers in Mexico and the United States. [Journal Article]Diabet Med. 2023 Feb 08 [Online ahead of print]DM
- CONCLUSIONS: Mothers sought to prevent Type 2 diabetes and live healthy lives, particularly, after receiving a diagnosis of gestational diabetes or when learning about their children's risks for Type 2 diabetes but perceived significant barriers to Type 2 diabetes prevention.
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- Comparative Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-Like Peptide 1 Receptor Agonists, and Nonsteroidal Mineralocorticoid Receptor Antagonists in Chronic Kidney Disease and Type 2 Diabetes: A Systematic Review and Network Meta-Analysis. [Journal Article]Diabetes Obes Metab. 2023 Feb 08 [Online ahead of print]DO
- CONCLUSIONS: SGLT-2i were associated with better cardiorenal protection than GLP-1RA and nsMRA in patients with CKD and T2D. This article is protected by copyright. All rights reserved.
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- Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate-activated protein kinase/mammalian target of the rapamycin pathway modulation. [Journal Article]Phytother Res. 2023 Feb 08 [Online ahead of print]PR
- Studies demonstrated that Ginkgo biloba extract (GBE) played a cardioprotective role in diabetic conditions. Impaired autophagy is one of the mechanisms underlying diabetic cardiomyopathy (DCM). The effect of GBE on autophagy has been observed in several diseases; however, whether GBE can ameliorate DCM by regulating autophagy remains unclear. Here, we investigated the effect of GBE on DCM and th…
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- New Drug: Tirzepatide (Mounjaro™). [Journal Article]Sr Care Pharm. 2023 Feb 01; 38(2):50-62.SC
- Type 2 diabetes mellitus (T2DM) is the most common form of diabetes and is a chronic and progressive illness. Millions of Americans have T2DM and many patients do not achieve the recommended blood glucose levels. Glucagon-like peptide 1 (GLP-1) based therapy is an established treatment for the management of T2DM and is recommended early in the treatment algorithm. GLP-1 therapy is associated with…
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- Geriatric Pharmacotherapy Case Series: Recurrent Angioedema Following Discontinuation of ACE Inhibitor Therapy. [Journal Article]Sr Care Pharm. 2023 Jan 01; 38(1):16-20.SC
- Introduction Angiotensin-converting enzyme inhibitors (ACEIs) are first-line pharmaceutical agents in common chronic conditions such as hypertension and heart failure with reduced ejection fraction. When angioedema occurs, if secondary to ACEIs, discontinuation of the ACEI is necessary to mitigate the risk of recurrent angioedema. While angioedema is a well-known adverse effect of ACEIs, it is no…
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- Exacerbation of financial burden of insulin and overall glucose-lowing medications among uninsured population with diabetes. [Journal Article]J Diabetes. 2023 Feb 07 [Online ahead of print]JD
- CONCLUSIONS: For insured people, the rising financial burden of insulin was borne mainly by insurance. The uninsured population is bearing a heavy burden due to the high price of insulin. Policymakers should take action to reduce the insulin price and improve the transparency of the insulin pricing process.
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- Prevalence and trends of adult overweight and obesity in Nigeria - A systematic review and meta-analysis. [Journal Article]Niger J Clin Pract. 2023 Jan; 26(1):1-15.NJ
- CONCLUSIONS: The prevalence of obesity and overweight in Nigeria is high with a rising trend over the years. A Nigerian national health survey of non-communicable diseases especially the burden of overweight/obesity is recommended to through more light on the subject. There is need for concerted effort to tame the tide of rising obesity rates in Nigeria.
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- Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease. [Journal Article]Neural Regen Res. 2023 Aug; 18(8):1818-1826.NR
- Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus. Therefore, using these two treatments may help treat Parkinson's disease. To further investigate the mechanisms of action of these two compounds, we established a model of Parkinson's disease by treating mice with 1-me…
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- Novel neuron-Schwann cell co-culture models to study peripheral nerve degeneration and regeneration. [Journal Article]Neural Regen Res. 2023 Aug; 18(8):1732-1733.NR
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- Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from India. [Journal Article]Indian J Med Res. 2022 Sep; 156(3):484-499.IJ
- CONCLUSIONS: In COVID-19, LFT abnormalities were common, and derangement increased as severity progressed. The presence of deranged LFT worsens the clinical outcome and predicts in-hospital mortality.
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- The effects of endurance exercise and metformin on memory impairment caused by diabetes. [Journal Article]Horm Mol Biol Clin Investig. 2023 Feb 09 [Online ahead of print]HM
- CONCLUSIONS: The results of the present study revealed both HIIT and MICT exercises had protective effects against oxidative stress and behavioral impairments induced by diabetes and these effects were comparable to the effects of metformin.
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- Variation in the reference range limits of thyroid function tests and association with the prevalence of levothyroxine treatment. [Journal Article]Eur J Endocrinol. 2023 Feb 08 [Online ahead of print]EJ
- Many individuals with marginally abnormal thyroid function test (TFT) results may be treated and it is unknown if the limits of the TSH and FT4 reference intervals reported alongside the laboratory results are associated with the prevalence of levothyroxine treatment. We obtained information regarding reported TFT reference intervals from UK National Health Service (NHS) laboratories and evaluate…
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- Diabetic Foot Risk Assessment among Patients with Type 2 Diabetes in Kenya. [Journal Article]East Afr Health Res J. 2022; 6(2):196-202.EA
- CONCLUSIONS: Our results show high rates of obesity, and poor glycaemic control in patients with type 2 diabetes and 56.5% of patients are categorised as being a moderate-to-high risk for foot problems. This highlights the need for healthcare professionals and patients in Kenya to be sensitised regarding the importance of foot screening to prevent lower-extremity complications.
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- Cumulative Human Immunodeficiency Virus (HIV)-1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019. [Journal Article]Open Forum Infect Dis. 2023 Feb; 10(2):ofac702.OF
- CONCLUSIONS: Among ART-treated WWH, greater cumulative viremia increased the risk of multimorbidity and of developing each NACM, and hence this may be a prognostically useful biomarker for NACM risk assessment in this population.
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- Association Between Hypocholesterolemia and Mortality in Critically Ill Patients With Sepsis: A Systematic Review and Meta-Analysis. [Review]Crit Care Explor. 2023 Feb; 5(2):e0860.CC
- CONCLUSIONS: Mortality was associated with lower levels of total cholesterol, HDL-cholesterol, and LDL-cholesterol, but not triglyceride levels, in patients admitted to ICU with sepsis. The impact of cholesterol replacement on patient outcomes in sepsis, particularly in at-risk groups, merits investigation.
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- Understanding comorbidities and health disparities related to COVID-19: a comprehensive study of 776 936 cases and 1 362 545 controls in the state of Indiana, USA. [Journal Article]JAMIA Open. 2023 Apr; 6(1):ooad002.JO
- CONCLUSIONS: This study characterizes the relationship between comorbidities and COVID-19 outcomes with respect to ICU admission across a large COVID-19 patient population in Indiana.
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- Rhinocerebral mucormycosis (RCM): To study the clinical spectrum and outcome of 61 cases of RCM managed at a tertiary care center in India. [Journal Article]Surg Neurol Int. 2023; 14:15.SN
- CONCLUSIONS: We report the largest single-center case series of RCM, comprising 61 patients. This case series underscores the importance of the early diagnosis and prompt treatment for a better prognosis for this dreadful disease. The three pillars of treatment for RCM cases include reversal of the immunosuppressive state, administration of antifungal drugs, and extensive surgical debridement. In spite of all this, mortality remains high.
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- Phlegmonous duodenitis in an immunocompromised patient. [Case Reports]DEN Open. 2023 Apr; 3(1):e212.DO
- Phlegmonous duodenitis is an extremely rare condition, and only a few cases have been previously reported. Here, we report a case of phlegmonous duodenitis caused by Streptococcus parasanguinis and Escherichia coli in a 78-year-old immunocompromised patient with diabetes mellitus and immunosuppressive drugs. Abdominal computed tomography showed diffuse thickening of the duodenum and gastric antru…
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- Rhabdomyolysis: An evidence-based approach. [Journal Article]J Intensive Care Soc. 2022 Nov; 23(4):513-517.JI
- A 76-year-old lady was found on the floor following a fall at home. She was uninjured, but unable to get up, and had been lying on the floor for roughly 18 hours before her son arrived. She had been unwell for the past 3 days with a cough and shortness of breath. She had a past medical history of diabetes, hypertension, hypercholesterolaemia and atrial fibrillation (AF). On examination, she was a…
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- Association of CHA2DS2-VASc score with successful recanalization in acute ischemic stroke patients undergoing endovascular thrombectomy. [Journal Article]Postepy Kardiol Interwencyjnej. 2022 Sep; 18(3):269-275.PK
- CONCLUSIONS: For the first time in the literature, we investigated and demonstrated that pre-stroke CHA2DS2-VASc score was associated with success of recanalization as assessed with mTICI 2c and mTICI 3 in a cohort of AIS patients regardless of AF presence who underwent endovascular treatment. Our findings deserve to be tested with large scale long term studies.
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- Bronchial Asthma Exacerbation in the Emergency Department in a Saudi Pediatric Population: An Insight From a Tertiary Hospital in Riyadh, Saudi Arabia. [Journal Article]Cureus. 2023 Jan; 15(1):e33391.C
- Background Severe uncontrolled asthma in the pediatric population is a complicated disease and is considered a major challenge for pediatricians. Severe bronchial asthma in the pediatric population is related to significant morbidity and mortality. Children with complicated asthma are at a higher risk for unfavorable outcomes, including medication-associated adverse effects, severe life-threateni…
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- Optic Neuritis in a Child With Poorly Controlled Type 1 Diabetes Mellitus: A Case Report. [Case Reports]Cureus. 2023 Jan; 15(1):e33474.C
- Type 1 diabetes stands among the most prevalent endocrinological diseases in the pediatric age group. The incidence rate continues to rise globally. Optic neuritis has been described in the literature in association with type 2 diabetes; however, cases of optic neuritis with type 1 diabetes are very few. Here we describe a rare case of a 15-year-old patient with type 1 diabetes mellitus presentin…
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- Women With Polycystic Ovary Syndrome: A Review of Susceptibility to Type 2 Diabetes. [Review]Cureus. 2023 Jan; 15(1):e33390.C
- The polycystic ovarian syndrome affects many women today. Previous research has demonstrated a direct link between it and serious ailments such as type 2 diabetes, heart disease, and infertility. Originally thought to be a reproductive disorder, polycystic ovarian syndrome (PCOS) is now understood to be a metabolic and psychological disorder. Women of reproductive age suffering from PCOS undergo …
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- Multifocal C-cell Hyperplasia and Marked Hypercalcitoninemia in a Diabetic Patient Treated With Glucagon-Like Peptide-1 Agonist With Concurrent Multinodular Goiter and Hyperparathyroidism. [Case Reports]Cureus. 2023 Jan; 15(1):e33384.C
- Thyroid C-cell hyperplasia (CCH) is divided into physiologic or reactive CCH and neoplastic CCH. Glucagon-like peptide-1 receptor agonists (GLP-1 Ra) is a group of medications used to treat type 2 diabetes that has documented C-cell stimulation effect in rodents, leading to subsequent CCH and medullary thyroid carcinoma (MTC) in rats and/or mice. Currently, there is no sufficient evidence support…
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