- Global disability-adjusted life-year estimates of long-term health burden and undernutrition attributable to diarrhoeal diseases in children younger than 5 years. [Journal Article]
- LGLancet Glob Health 2018; 6(3):e255-e269
- CONCLUSIONS: Diarrhoea represents an even larger burden of disease than was estimated in the Global Burden of Disease Study. In order to adequately address the burden of its long-term sequelae, a renewed emphasis on controlling the risk of diarrhoea incidence may be required. This renewed effort can help further prevent the potential lifelong cost on child health, growth, and overall potential.
- The relationship between gastrointestinal symptom attribution, bothersomeness, and antiretroviral adherence among adults with HIV. [Journal Article]
- ACAIDS Care 2018 Feb 07; :1-7
- Patients who attribute their symptoms to HIV medications, rather than disease, may be prone to switching antiretrovirals (ARVs) and experience poor retention/adherence to care. Gastrointestinal (GI) ...
Patients who attribute their symptoms to HIV medications, rather than disease, may be prone to switching antiretrovirals (ARVs) and experience poor retention/adherence to care. Gastrointestinal (GI) symptoms (e.g., nausea/vomiting) are often experienced as a side effect of ARVs, but little is known about the relationship of symptom attribution and bothersomeness to adherence. We hypothesized that attribution of a GI symptom to ARVs is associated with a reduction in adherence, and that this relationship is moderated by the bothersomeness of the symptom. Data for our analysis come from the pre-randomization enrollment period of a larger study testing an adherence improvement intervention. Analyses revealed that patients with diarrhea who attributed the symptom to ARVs (compared to those who did not) had significantly worse adherence. We did not find a significant moderating effect of bothersomeness on this relationship. Incorporating patient beliefs about causes of symptoms into clinical care may contribute to improved symptom and medication management, and better adherence.
- Common Gastrointestinal Complications Associated with Human Immunodeficiency Virus/AIDS: An Overview. [Review]
- CCCrit Care Nurs Clin North Am 2018; 30(1):101-107
- Highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV)/AIDS into a manageable chronic illness. People living with HIV/AIDS (PLWHA) can experience multiple phy...
Highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV)/AIDS into a manageable chronic illness. People living with HIV/AIDS (PLWHA) can experience multiple physical symptoms or problems related to HIV infection and treatment. A common problem for PLWHA continues to be diarrhea and nausea and vomiting (NV). Diarrhea and NV can negatively impact the quality of life and adherence to medication therapy among PLWHA and are common reasons to change or discontinue HAART regimens. Because diarrhea and NV can have substantial negative health outcomes for PLWHA, it is important to understand the causes of these conditions.
- Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract. [Review]
- MPMod Pathol 2018 Feb 05
- Immune compromise may result from genetic abnormalities, HIV/AIDS, or consequences of therapy for neoplastic and autoimmune diseases. Many immunocompromised patients develop severe gastrointestinal s...
Immune compromise may result from genetic abnormalities, HIV/AIDS, or consequences of therapy for neoplastic and autoimmune diseases. Many immunocompromised patients develop severe gastrointestinal symptoms, particularly diarrhea, accompanied by non-specific or mild endoscopic abnormalities; mucosal biopsy with pathologic interpretation has a major role in the diagnosis and management of these patients. Immunocompromised individuals are at risk for all the diseases that affect those with a healthy immune system, but they are also prone to other illnesses that rarely affect immunocompetent patients. This review discusses the gastrointestinal manifestations of primary and acquired immunodeficiency, chemotherapy-related injury, and infections that show a predilection for immunocompromised patients. Key histologic features and relevant differential diagnoses are emphasized.
- Brentuximab vedotin with AVD shows safety, in the absence of strong CYP3A4 inhibitors, in newly diagnosed HIV-associated Hodgkin lymphoma. [Journal Article]
- AIDSAIDS 2017 Dec 26
- CONCLUSIONS: AVD-BV was well tolerated at recommended phase II dose of 1.2 mg/kg. Concurrent strong CYP3A4 inhibitors should be avoided. A phase II study of AVD-BV is currently enrolling (NCT01771107).
- National survey of Ebola-related knowledge, attitudes and practices before the outbreak peak in Sierra Leone: August 2014. [Journal Article]
- BGBMJ Glob Health 2017; 2(4):e000285
- CONCLUSIONS: Three months into the 2014 Ebola outbreak in Sierra Leone, our findings suggest there was high awareness of the disease but misconceptions and discriminatory attitudes toward survivors remained common. These findings directly informed the development of a national social mobilisation strategy and demonstrated the importance of KAP assessment early in an epidemic.
- Evaluation of Parasitological Methods for the Detection ofStrongyloides Stercoralisamong Individuals in Selected Health Institutions In Addis Ababa, Ethiopia. [Journal Article]
- EJEthiop J Health Sci 2017; 27(5):515-522
- Strongyloides stercoralis causes chronic intestinal infection that may lead to disseminated disease during immunosuppression. Therefore, efficient diagnostic methods are essential to detect silent an...
Strongyloides stercoralis causes chronic intestinal infection that may lead to disseminated disease during immunosuppression. Therefore, efficient diagnostic methods are essential to detect silent and latent infections. The present study was aimed to compare the efficacy of parasitological methods for the detection of S. stercoralis infection.
- Infectious diseases in Poland in 2015 [Journal Article]
- PEPrzegl Epidemiol 2017; 71(3):295-309
- This is the next annual analysis of the situation of infectious and parasitic diseases in Poland in 2015 within the framework of the Epidemiological Chronicle of Przegląd Epidemiologiczny - Epidemiol...
This is the next annual analysis of the situation of infectious and parasitic diseases in Poland in 2015 within the framework of the Epidemiological Chronicle of Przegląd Epidemiologiczny - Epidemiological Review. Its purpose is to identify potential threats to the health of populations from infectious diseases occurring in Poland with reference to other parts of the globe.
- [Infection by the Mycobacterium avium-intracellulare complex in patients with HIV/AIDS in a Peruvian hospital: A series of cases]. [Case Reports]
- RPRev Peru Med Exp Salud Publica 2017 Apr-Jun; 34(2):323-327
- There is little information on the presence of the Mycobacterium avium-Intracellulare (MAC) complex in Peru. Five cases of MAC infection are described in patients with HIV/AIDS at the National Hospit...
There is little information on the presence of the Mycobacterium avium-Intracellulare (MAC) complex in Peru. Five cases of MAC infection are described in patients with HIV/AIDS at the National Hospital Dos de Mayo, Lima - Peru. The patients presented, mainly, persistent fever, chronic diarrhea, consumptive syndrome, pancytopenia and citofagocitosis. In all of them, resistant acid-alcohol bacilli were identified in feces, so they received antituberculous treatment. The culture of feces was negative for Mycobacterium tuberculosis and, later, in all cases MAC was identified using a molecular test (genotype) in the culture of feces. Three patients received treatment for MAC right after identification; however, they all died. Before presentations similar to the reported, we suggest the use of higher performance methods (blood culture, myeloculture, molecular tests), as well as early associating drugs with activity for MAC to antitubercular scheme with the intention of improving the prognosis of this group of patients.
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- [Disseminated histoplasmosis and HIV infection: Case series in a Peruvian hospital]. [Journal Article]
- RCRev Chilena Infectol 2017; 34(4):365-369
- CONCLUSIONS: We describe the clinical characteristics of a group of patients who had DH as HIV coinfection and this is still a quasi endemic reality in patients suffering from this pathology.