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(Diet during Cancer Treatment)
26,784 results
  • Pseudodiabetes-not a contraindication for metabolic interventions. [Journal Article]
    Cell Death Dis 2019; 10(10):765Bravo-San Pedro JM, Sica V, Kroemer G
  • Type-2 diabetes is characterized by glycosuria, hyperglycemia, glucose intolerance, hyperinsulinemia, and insulin resistance. One or several among these alterations are also found after starvation, ketogenic diet, and pharmacological treatment with rapamycin or antibody-mediated neutralization of the obesogenic factor ACBP/DBI. Thus, a variety of metabolic interventions that improve metabolic hea…
  • The Pharmacokinetics of Vitamin C. [Review]
    Nutrients 2019; 11(10)Lykkesfeldt J, Tveden-Nyborg P
  • The pharmacokinetics of vitamin C (vitC) is indeed complex. Regulated primarily by a family of saturable sodium dependent vitC transporters (SVCTs), the absorption and elimination are highly dose-dependent. Moreover, the tissue specific expression levels and subtypes of these SVCTs result in a compartmentalized distribution pattern with a diverse range of organ concentrations of vitC at homeostas…
  • Gastric Adenocarcinoma in a Moroccan Population: First Report on Survival Data. [Journal Article]
    Gulf J Oncolog 2019; 1(31):36-40Lahmidani N, Miry S, … Najdi A
  • CONCLUSIONS: The high mortality of gastric adenocarcinoma in our Moroccan series is probably explained by the late stage at diagnosis. Symptoms are nonspecific and endoscopy is usually performed for advanced symptoms such as anemia, bleeding or weight loss. The main identified prognostic factors in gastric adenocarcinoma are tumor subtype (Linitic forms), stage at diagnosis, vascular and lymph nodes invasion and general performance status which correlates to available data in the literature. Besides, the age distribution of GC in our series showed that the proportion of affected young adult is high (30.6%) compared to data from developed countries varying between 6 and 15%. This age distribution can be explained by the Westernization of diet, the increase of obesity in our population and more exposure to alcohol and tobacco.Overall cancer survival in our population does not exceed 7%, a rate that remains low compared to studies published in the occidental literature. Recommendations have to be elaborated to make a strategy for screening and early diagnosis of gastric adenocarcinoma to improve the survival rate.
  • Sirtuins and SIRT6 in Carcinogenesis and in Diet. [Review]
    Int J Mol Sci 2019; 20(19)de Céu Teixeira M, Sanchez-Lopez E, … Souto EB
  • Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the…
  • KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. [Journal Article]
    Int J Mol Sci 2019; 20(19)Vieceli Dalla Sega F, Mastrocola R, … Retta SF
  • Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the human population. However, growing evidence demonstrates that KRIT1 is implicated in the modulation of major red…
  • Dealing with saturated and unsaturated fatty acid metabolism for anticancer therapy. [Journal Article]
    Curr Opin Clin Nutr Metab Care 2019; 22(6):427-433Dierge E, Feron O
  • CONCLUSIONS: The various enzymatic reactions leading to SFA synthesis represent as many targets to prevent tumor growth. Ironically excess SFAs are per-se toxic for cancer cells and the introduction of a double bound to form MUFA is actually limiting lipotoxicity in cancer cells. Blocking stearoyl-CoA desaturase therefore represents another attractive modality. By contrast, dietary PUFAs may exert direct cytotoxic effects by promoting apoptosis or by generating anti-inflammatory eicosanoids. Altogether, these data point out the intricate relationship between SFA, MUFA and PUFA at the heart of the metabolism of proliferating cancer cells.
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