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(Dipetalonema perstans)
525 results
  • DNA Barcoding of genus Culicoides biting midges (Diptera: Ceratopogonidae) in the Brazilian Amazon. [Journal Article]
    Acta Trop. 2022 Jul 26 [Online ahead of print]Carvalho LPC, da Silva Costa G, … Medeiros JF
  • Culicoides biting midges are capable to transmit Oropouche virus, Bluetongue virus and Mansonella spp. This study aimed to assess the utility of DNA barcode as an alternative method in the Culicoides species identification. The study was conducted in Jamari National Forest. Biting midges were collected using HP light traps during four months, February, April, August and October, 2018. Insects wer…
  • A large case series of travel-related Mansonella perstans (vector-borne filarial nematode): a TropNet study in Europe. [Journal Article]
    J Travel Med. 2022 Apr 13 [Online ahead of print]Tamarozzi F, Rodari P, … Gobbi FG
  • CONCLUSIONS: Lack of specific symptoms, together with the inconstant positivity of parasitological and antibody-based assays in the infected population, make the clinical suspicion and screening for mansonellosis particularly difficult. Prospective studies evaluating prevalence of infection in migrants from endemic areas, infection-specific morbidity, presence of Wolbachia endosymbionts in M. perstans populations from different geographical areas, and efficacy of treatment regimens are absolutely needed to optimize the clinical management of infection.
  • Filarids (Spirurida: Onchocercidae) in wild carnivores and domestic dogs from the Brazilian Atlantic forest. [Journal Article]
    PLoS Negl Trop Dis. 2022 03; 16(3):e0010213.Figuerêdo Duarte Moraes M, de Souza Pollo A, Lux Hoppe EG
  • Onchocercidae nematodes are heteroxenous parasites with worldwide distribution, and some of the species associated to animals may present zoonotic potential. Climatic changes and anthropic influences on the environment may result in vectors' proliferation, facilitating the spillover to humans and/or non-typical animal hosts. The Iguaçu National Park (PARNA Iguaçu), one of the most important Brazi…
  • Diagnostic performance of capillary and venous blood samples in the detection of Loa loa and Mansonella perstans microfilaraemia using light microscopy. [Journal Article]
    PLoS Negl Trop Dis. 2021 08; 15(8):e0009623.Mischlinger J, Manego RZ, … Ramharter M
  • CONCLUSIONS: This analysis indicates that average levels of microfilaraemia of L. loa are higher in CAP blood samples than in VEN blood samples. This might have implications for treatment algorithms of onchocerciasis and loiasis, in which exact quantification of L. loa microfilaraemia is of importance. Furthermore, the odds for detection of M. perstans microfilariae was higher in CAP than in VEN blood which may pre-dispose CAP blood for detection of M. perstans infection in large epidemiological studies when sampling of large blood quantities is not feasible. No solid evidence for a higher odds of L. loa microfilariae detection in CAP blood was revealed, which might be explained by generally high levels of L. loa microfilaraemia in CAP and VEN blood above the limit of detection of 100 microfilariae/ml. Yet, it cannot be excluded that the study was underpowered to detect a moderate difference.
  • Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon. [Journal Article]
    Parasit Vectors. 2021 Aug 11; 14(1):397.Wewer V, Peisker H, … Dörmann P
  • CONCLUSIONS: On an individual level, NATOG alone had poor discriminative power distinguishing infected from non-infected individuals. However, 13.8% of all O. volvulus-infected individuals had NATOG levels never reached by individuals without filarial infections or infected with only L. loa or M. perstans. Discrimination of O. volvulus infections from controls or individuals suffering from multiple infections was improved by the measurement of additional metabolites, e.g. cinnamoylglycine. Thus, measuring a combination of urine metabolites may provide a way to assess onchocerciasis on the population level. This provides the possibility to design a strategy for large-scale onchocerciasis epidemiological screening programs based on urine rather than invasive techniques.
  • An Overview of the Management of Mansonellosis. [Review]
    Res Rep Trop Med. 2021; 12:93-105.Ta-Tang TH, Luz SLB, … Rubio JM
  • Mansonellosis is caused by three filarial parasite species from the genus Mansonella that commonly produce chronic human microfilaraemias: M. ozzardi, M. perstans and M. streptocerca. The disease is widespread in Africa, the Caribbean and South and Central America, and although it is typically asymptomatic it has been associated with mild pathologies including leg-chills, joint-pains, headaches, …
  • Genome editing as control tool for filarial infections. [Review]
    Biomed Pharmacother. 2021 May; 137:111292.Kwarteng A, Sylverken A, … Ahuno ST
  • Human filarial infections are vector-borne nematode infections, which include lymphatic filariasis, onchocerciasis, loiasis, and mansonella filariasis. With a high prevalence in developing countries, filarial infections are responsible for some of the most debilitating morbidities and a vicious cycle of poverty and disease. Global initiatives set to eradicate these infections include community ma…
  • Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model. [Review]
    Parasitol Res. 2021 Dec; 120(12):4125-4143.Risch F, Ritter M, … Hübner MP
  • Filariae are vector-borne parasitic nematodes that are endemic worldwide, in tropical and subtropical regions. Important human filariae spp. include Onchocerca volvulus, Wuchereria bancrofti and Brugia spp., and Loa loa and Mansonella spp. causing onchocerciasis (river blindness), lymphatic filariasis (lymphedema and hydrocele), loiasis (eye worm), and mansonelliasis, respectively. It is estimate…
  • Filariasis and transfusion-associated risk: a literature review. [Review]
    Vox Sang. 2021 Aug; 116(7):741-754.Drews SJ, Spencer BR, … International Society of Blood Transfusion TTID Working Party Parasite Subgroup
  • CONCLUSIONS: Rare examples of transfusion-transmitted filariasis, without serious clinical effect, suggest that filariasis poses low transfusion risk. Dedicated mitigation strategies against filarial transfusion transmission are not recommended. Given endemicity in low-resource regions, priority should be on the control of filariasis with public health measures.
  • Molecular Epidemiology of Mansonella Species in Gabon. [Journal Article]
    J Infect Dis. 2021 02 03; 223(2):287-296.Sandri TL, Kreidenweiss A, … Held J
  • Mansonella perstans, a filarial nematode, infects large populations in Africa and Latin America. Recently, a potential new species, Mansonella sp "DEUX," was reported. Carriage of endosymbiotic Wolbachia opens treatment options for Mansonella infections. Within a cross-sectional study, we assessed the prevalence of filarial infections in 834 Gabonese individuals and the presence of the endosymbio…
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