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51 results
  • Releasing the flood waters: diuril and the reshaping of hypertension. [Historical Article]
    Bull Hist Med. 2005 Winter; 79(4):749-94.Greene JA
  • This article narrates the development and promotion in the 1950s and 1960s of Merck, Sharp & Dohme's Diuril (chlorothiazide), an antihypertensive drug, which played a significant role in the redefinition of high blood pressure as a widespread target for chronic pharmaceutical consumption. The joined careers of Diuril and hypertension in the late twentieth century demonstrate the connections betwe…
  • Thiazide diuretics and the risk of gallbladder disease requiring surgery in women. [Journal Article]
    Arch Intern Med. 2005 Mar 14; 165(5):567-73.Leitzmann MF, Tsai CJ, … Giovannucci E
  • CONCLUSIONS: These findings are compatible with the hypothesis that the use of thiazide diuretics increases the risk of symptomatic cholecystitis. However, we cannot rule out the possibility that our results are in part explained by unconsidered factors related to the indication for antihypertensive therapy or by differences in medical surveillance between users and nonusers of thiazide diuretics.
    Can Med Assoc J. 1963 Dec 21; 89:1266-9.HARRISON J, MCNEILL KG
  • The therapeutic value of the diuretic, chlorothiazide (Diuril), in reducing the body burden of cesium-137 in human subjects was investigated. Two subjects were given chlorothiazide, 2 g./day, following a single oral intake of cesium-137. The urinary excretion and the per cent retention of cesium-137 were compared with similar data obtained from two control subjects. Although chlorothiazide produc…
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