- Antituberculosis Drug-Induced Fixed Drug Eruption: A Case Report. [Journal Article]
- DSDrug Saf Case Rep 2018 May 21; 5(1):23
- Fixed drug eruption (FDE) was caused by fixed-dose combination (FDC) of antituberculosis drugs in the form of tablet Forecox® (rifampicin [rifampin] 225 mg + isoniazid 150 mg + pyrazinamide 750 mg + ...
Fixed drug eruption (FDE) was caused by fixed-dose combination (FDC) of antituberculosis drugs in the form of tablet Forecox® (rifampicin [rifampin] 225 mg + isoniazid 150 mg + pyrazinamide 750 mg + ethambutol 400 mg) in a 40-year-old male patient with a history of drug allergy. The patient developed FDE after taking the third dose of tablet Forecox® for pulmonary tuberculosis. Tablet Forecox® was withdrawn and the patient recovered from the reaction after 15 days of treatment for FDE. As per World Health Organization-Uppsala Monitoring Centre (WHO-UMC) and Naranjo causality assessment criteria, the association between the reaction and tablet Forecox® was possible and probable, respectively. The reaction was moderately (Level 4b) severe according to the Modified Hartwig and Siegel scale. As there is an increased risk of allergic reaction in patients with a history of drug allergy, FDCs should not be used in order to avoid complexity in identifying the culprit drug.
- Occupational fixed drug eruption with ipe wood. [Journal Article]
- CDContact Dermatitis 2018 May 15
- Bullous Fixed Drug Eruption Following Ibuprofen Ingestion. [Journal Article]
- JRJ Res Pharm Pract 2018 Jan-Mar; 7(1):51-56
- Fixed drug eruption (FDE) is a drug reaction involving skin and less commonly mucosal membranes. The common manifestation is localized well-demarcated patches or plaques appeared following receiving ...
Fixed drug eruption (FDE) is a drug reaction involving skin and less commonly mucosal membranes. The common manifestation is localized well-demarcated patches or plaques appeared following receiving of a culprit drug. When re-exposure occurs, the rashes will appear at areas involved in previous episodes. Limited reports on bullous FDE due to ibuprofen have been documented before. Herein, we described an elderly man who experienced multifocal lesions in his oral mucosa, penis, and multiple sites of skin following ibuprofen ingestion confirmed as FDE by pathological studies. The culprit drug had been discontinued. Systemic and topical glucocorticoids as well as supportive care had been instituted. The patient's outcome was favorable and his lesions had been recovered within the next weeks. Patient's follow-up showed that he had received ibuprofen again sometime later resulting in anal mucosal lesion and similar penile involvement. In routine clinical practice, mucocutaneous adverse drug reactions should be considered. A high index of suspicion, the detailed medication history, the course of the symptoms, and distributing pattern of the lesions are essential clues for the diagnosis. However, judicious and prompt pathological studies can help to differentiate multifocal bullous FDE from major skin drug reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis.
- Recurrent and Fixed Neutrophilic Dermatosis Associated With Dasatinib. [Journal Article]
- JCJ Cutan Med Surg 2018 May 01; :1203475418775663
- CONCLUSIONS: This report extends the clinical spectrum of neutrophilic dermatoses to include dasatinib-induced recurrent and fixed erythematous plaques.
- A 10-years retrospective study on Severe Cutaneous Adverse Reactions (SCARs) in a tertiary hospital in Penang, Malaysia. [Journal Article]
- MJMed J Malaysia 2018; 73(2):73-77
- CONCLUSIONS: The commonest manifestations of SCARs in our setting were SJS, TEN and DRESS. Allopurinol was the most common culprit. Thus, judicious allopurinol use is advocated and pre-emptive genetic screening for HLAB *5801 should be considered.
- Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis. [Journal Article]
- IAInt Arch Allergy Immunol 2018 Apr 03
- CONCLUSIONS: Future studies assessing the risk of immediate and nonimmediate hypersensitivity reactions to acetaminophen and elucidating the mechanism of acetaminophen hypersensitivity reactions are required.
- Fixed drug eruption associated with aspirin. [Journal Article]
- BCBMJ Case Rep 2018 Mar 17; 2018
- Comments on Ben Mansour et al: Additional cases of multifocal fixed drug eruption to ceftazidime. [Letter]
- PAPediatr Allergy Immunol 2018 Mar 14
- Mucosal fixed drug eruption due to mefenamic acid: Report of a case and a review. [Letter]
- TTherapie 2018 Feb 15
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- Changing trends in inducer drugs of fixed drug eruption: a 20-year cross-sectional study from Turkey. [Letter]
- JDJ Dtsch Dermatol Ges 2018; 16(4):474-476