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(EKG: left atrial enlargement)
1,145 results
  • Cardiometabolic assessment of lamin A/C gene mutation carriers: A phenotype-genotype correlation. [Journal Article]
  • DMDiabetes Metab 2018 Oct 01
  • Kwapich M, Lacroix D, … Diamenord–AEDNL Working Group
  • CONCLUSIONS: Non-R482 carriers present more frequently with arrhythmias than R482 carriers, who twice as often have diabetes, suggesting that follow-up for laminopathies could be adjusted for genotype. Non-R482 mutations require ultra-specialized cardiac follow-up, and coronary artery disease should not be overlooked. Although overlapping phenotypes are found, LMNA mutations essentially lead to tissue-specific diseases, favouring genotype-specific pathophysiological mechanisms.
  • Utility of serial 12-lead electrocardiograms in children with Marfan syndrome. [Journal Article]
  • CYCardiol Young 2018; 28(8):1009-1013
  • Arunamata AA, Nguyen CT, … Selamet Tierney ES
  • CONCLUSIONS: While Marfan patients exhibited a higher frequency of left atrial enlargement and left ventricular hypertrophy on 12-lead electrocardiograms compared with controls, these findings were not supported by echocardiography. Serial 12-lead electrocardiograms in routine follow-up of asymptomatic paediatric Marfan patients may be more appropriate for a subgroup of Marfan patients only, specifically those with prolonged QTc interval at their baseline visit.
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