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1,972 results
  • SIP1 serves a role in HBx‑induced liver cancer growth and metastasis. [Journal Article]
    Int J Oncol 2019Ye Y, Yang J, … Chen W
  • Hepatitis B virus (HBV) has been revealed to be involved in the development of hepatocellular carcinoma. However, the mechanism remains to be fully elucidated. Smad‑interacting protein 1 (SIP1) is a transcriptional repressor, which serves a pivotal role in cell metastasis. In the present study, the role of SIP1 in HBx‑induced hepatocyte EMT and cancer aggressiveness was examined. It was found tha…
  • Cellular and Molecular Mechanism of Ganoderma (Lingzhi) Against Tumor. [Review]
    Adv Exp Med Biol 2019; 1182:79-118Sun Y, Sun L
  • The anticancer potential of Ganoderma (Lingzhi) and its extracts has been widely demonstrated, including antiproliferative and apoptosis inductive, antimetastatic, antiangiogenic, and multidrug resistance reversional activities, involving a variety of cellular and molecular mechanisms besides antitumor immunology. Intrinsic- and extrinsic-initiated apoptotic pathway in association with cell cycle…
  • LncRNA MALAT1 regulates trophoblast cells migration and invasion via miR-206/IGF-1 axis. [Journal Article]
    Cell Cycle 2019; :1-14Wu HY, Wang XH, … Zhang JL
  • Preeclampsia (PE) is a pregnancy-specific syndrome that substantially leads to maternal and fetal mortality. Multiple factors contribute to the disease, but the exact pathogenesis still remains elusive. Here we explored the roles of lncRNA MALAT1 and miR-206 in PE. qRT-PCR was applied to measure mRNA levels of MALAT1 and miR-206 in the placenta of PE patients. Scratch wound healing assay and tran…
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