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888 results
  • Successful use of phlebotomy to treat severe secondary polycythemia due to chronic lung disease. [Journal Article]
    Hematol Rep. 2021 Jun 09; 13(2):8961.Fuqua J, Reece J, Sofka S
  • Secondary polycythemia (SP) occurs as a result of increase erythropoietin levels most commonly as a result of tissue hypoxia. Symptoms such as erythromelalgia, pruritis, and bleeding, which are frequently seen in polycythemia vera (PV), do not commonly occur in SP. Phlebotomy is considered one of the mainstays of therapy for PV but is rarely used for treatment of SP due to concern about worsening…
  • A reappraisal of the presence of small or large fiber neuropathy in patients with erythromelalgia. [Journal Article]
    Neurophysiol Clin. 2021 Apr 19 [Online ahead of print]Reach P, Lazareth I, … Zuber M
  • CONCLUSIONS: Peripheral neuropathy, mostly involving small nerve fibers, is almost as common as microvascular changes in EM, but remains inconstant and not related to a specific neuropathic pattern or higher clinical severity.The association of neuropathic and vascular factors is not systematic in EM, this syndrome being characterized by different pathophysiological mechanisms leading to a common clinical phenotype.
  • Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. [Journal Article]
    J Am Acad Dermatol. 2021 07; 85(1):46-55.McMahon DE, Amerson E, … Freeman EE
  • CONCLUSIONS: We report a spectrum of cutaneous reactions after mRNA COVID-19 vaccines. We observed some dermatologic reactions to Moderna and Pfizer vaccines that mimicked SARS-CoV-2 infection itself, such as pernio/chilblains. Most patients with first-dose reactions did not have a second-dose reaction and serious adverse events did not develop in any of the patients in the registry after the first or second dose. Our data support that cutaneous reactions to COVID-19 vaccination are generally minor and self-limited, and should not discourage vaccination.
  • Acral vascular syndrome Lennert type T cell lymphoma-a case report. [Journal Article]
    J Egypt Natl Canc Inst. 2021 Mar 04; 33(1):8.Klanidhi KB, Monian SA, Chakrawarty A
  • CONCLUSIONS: Acral vascular syndrome can be a presentation of lymphoma; if intervened earlier, the patient can be saved from the amputation of fingers or affected limb. Though it is a rare presentation of lymphoma, it should be considered if there is a rapid progression of gangrene. Early initiation of chemotherapy may result in the reduction of further progression of digital gangrene and thus prevents functional dependence on caregivers. In our patient, gangrene of other fingers was prevented even though it is an aggressive variant of T cell lymphoma.
  • Painful, reappearing eruption in a medically complex 4-year-old. [Case Reports]
    BMJ Case Rep. 2021 Feb 18; 14(2)Sooy M, Randell RL, … Nazareth-Pidgeon K
  • A 4-year-old boy with atypical, complete DiGeorge and CHARGE (coloboma, heart defects, atresia choanae, growth retardation, genital abnormalities and ear abnormalities) syndromes presented with frequent episodes of a painful, markedly erythematous eruption associated with swelling. Evaluation revealed non-specific findings on skin biopsy at the time of eruption and no pathogenic mutation in the S…
  • Two Cases of Severe Hypertension in JAK2 Mutation-Positive Myeloproliferative Neoplasms. [Case Reports]
    Case Rep Vasc Med. 2020; 2020:8887423.Rao R, Kulkarni S, Wilkinson IB
  • CONCLUSIONS: These presentations highlight the utility of full blood count analysis in patients with severe hypertension. Hyperviscosity and constitutive JAK-STAT activation are amongst the proposed pathophysiology linking myeloproliferative neoplasms and hypertension. Further experimental and clinical research is necessary to identify and understand possible interactions between BP and myeloproliferative neoplasms.
  • Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect. [Journal Article]
    Channels (Austin). 2021 12; 15(1):208-228.Le Cann K, Meents JE, … Lampert A
  • Mutations in the voltage-gated sodium channel Nav1.7 are linked to human pain. The Nav1.7/N1245S variant was described before in several patients suffering from primary erythromelalgia and/or olfactory hypersensitivity. We have identified this variant in a pain patient and a patient suffering from severe and life-threatening orthostatic hypotension. In addition, we report a female patient sufferi…
  • Erythromelalgia Caused by Polycythemia Vera Combined with Primary Aldosteronism. [Journal Article]
    Eur J Case Rep Intern Med. 2020; 7(11):001852.Suzuki M, Watari T
  • A 61-year-old woman with a history of primary aldosteronism caused by unilateral hyperplasia of the adrenal gland presented with a 2-week history of redness and severe pain in the right thumb and thenar regions. She had initially visited a dermatologist and was diagnosed with cellulitis and treated with cefditoren pivoxil for 5 days, but there was no improvement. The pain worsened and was accompa…
  • Acute monophasic erythromelalgia pain in five children diagnosed as small-fiber neuropathy. [Case Reports]
    Eur J Paediatr Neurol. 2020 Sep; 28:198-204.Faignart N, Nguyen K, … Roulet Perez E
  • The small-fiber polyneuropathies (SFN) are a class of diseases in which the small thin myelinated (Aδ) and/or unmyelinated (C) fibers within peripheral nerves malfunction and can degenerate. SFN usually begins in the farthest, most-vulnerable axons, so distal neuropathic pain and symptoms from microvascular dysregulation are common. It is well known in adults, e.g. from diabetes, human immunodefi…
  • Heater-Associated Erythema Ab Igne: Case Report and Review of Thermal-Related Skin Conditions. [Case Reports]
    Cureus. 2020 May 11; 12(5):e8057.Forouzan P, Riahi RR, Cohen PR
  • Erythema ab igne is a thermal-associated skin condition that can occur secondary to persistent direct or indirect contact with heat. Historically, erythema ab igne has been linked to fireplace and stove exposures; more recently, it has been associated with heaters, hot water bottles, and laptops. A 48-year-old woman presented for the evaluation of hyperpigmented, reticulated macular lesions on he…
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