- External validation of an NTCP model for acute esophageal toxicity in locally advanced NSCLC patients treated with intensity-modulated (chemo-)radiotherapy. [Journal Article]
- RORadiother Oncol 2018 Sep 18
- CONCLUSIONS: The NTCP model for AET prediction was successfully validated in three out of five patient cohorts (AUC ≥0.80). The model did not perform well in two cohorts, which included patients receiving substantially different treatment. Before applying the model in clinical practice, validation of discrimination and (re)calibration performance in a local cohort is recommended.
- Analysis of Mid-esophageal Biopsies Increases Sensitivity of Detection of Eosinophilic Esophagitis. [Journal Article]
- CGClin Gastroenterol Hepatol 2018 Sep 18
- Pediatric eosinophilic esophagitis: updates for the primary care setting. [Journal Article]
- COCurr Opin Pediatr 2018 Sep 20
- CONCLUSIONS: The current review will focus on the diagnosis and management of EoE in the pediatric population. Identification and diagnosis of pediatric patients with EoE is critical to prevent long-term esophageal complications.
- Symptomatic exfoliative esophagitis induced by dabigatran. [Journal Article]
- RERev Esp Enferm Dig 2018 Sep 21; 110
- Dabigatran is an oral anticoagulant prescribed as an alternative to warfarin which has been associated with exfoliative esophagitis and esophageal ulcer. We report a new case of dabigatran-induced ex...
Dabigatran is an oral anticoagulant prescribed as an alternative to warfarin which has been associated with exfoliative esophagitis and esophageal ulcer. We report a new case of dabigatran-induced exfoliative esophagitis where the mucosal injury improved after prescribing proton-pump inhibitors and ingesting medication with sufficient water.
- Respiratory symptoms associated with eosinophilic esophagitis. [Review]
- PPPediatr Pulmonol 2018 Sep 20
- Eosinophilic esophagitis (EoE) is an atopic condition diagnosed based on eosinophilic infiltration in the esophagus and symptoms of esophageal dysfunction. Typical clinical manifestations of EoE incl...
Eosinophilic esophagitis (EoE) is an atopic condition diagnosed based on eosinophilic infiltration in the esophagus and symptoms of esophageal dysfunction. Typical clinical manifestations of EoE include feeding refusal, vomiting, and dysphagia however recent reports highlight an associations with extraesophageal symptoms. By definition the inflammatory response in EoE is restricted to the esophagus. However, accounts of symptoms such as chronic refractory cough, recurrent croup, hoarseness as well as subglottic stenosis, and an increase in otolaryngologic surgeries in patients with EoE raise the possibility of extraesophageal manifestations of the disease. These symptoms have been reported at times in the absence of typical gastrointestinal symptoms. While the condition is usually managed by gastroenterologist and/or allergist, the presence of extraesophageal symptoms and comorbid conditions may result in patients presenting initially to providers in other subspecialties such as pulmonology and otorhinolaryngology. The use of proton pump inhibitors and corticosteroids are part of the management of EoE. Awareness of the possibility of EoE before the empiric use of these therapies is important as there use can make identifying and diagnosing patients with EoE correctly challenging. We review the medical literature regarding extraesophageal manifestations of EoE and highlight the importance of awareness for subspecialist outside of gastroenterology and allergy for the condition.
- Correlation Between Symptomatic Gastro-Esophageal Reflux Disease (GERD) and Erosive Esophagitis (EE) Post-vertical Sleeve Gastrectomy (VSG). [Journal Article]
- OSObes Surg 2018 Sep 21
- CONCLUSIONS: Although LSG is effective in treating obesity and its metabolic syndromes, the prevalence of EE increased significantly 1 year after the surgery. Since we do not fully understand the long-term impact of chronic esophagitis in post-sleeve population, we recommend follow-up EGD assessment post-operatively and treat the esophagitis if present.
- Amifostine- and chemoradiotherapy-related esophagitis in small cell lung cancer: a single institutional series and literature update. [Journal Article]
- LCLung Cancer (Auckl) 2018; 9:79-84
- CONCLUSIONS: In this modern retrospective series of thoracic chemoradiotherapy in the treatment of stage 3 small cell lung cancer, amifostine that was delivered subcutaneously postponed the onset of esophagitis.
- Editorial: Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation. [Editorial]
- FMFront Med (Lausanne) 2018; 5:243
- Multidisciplinary approach to the management of adult eosinophilic oesophagitis in the United Kingdom. [Letter]
- CEClin Exp Allergy 2018 Sep 19
- Dietary intervention is effective for the management of eosinophilic oesophagitis (EoE) in both adults and children . The majority of research has been conducted in Spain or the United States ,...
Dietary intervention is effective for the management of eosinophilic oesophagitis (EoE) in both adults and children . The majority of research has been conducted in Spain or the United States , with no studies of dietary intervention published in the United Kingdom. Restrictive elimination diets can be challenging and swallowed topical corticosteroids have also been shown to be an effective treatment in adults This article is protected by copyright. All rights reserved.
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- Surgical results of laparoscopic Toupet fundoplication for gastroesophageal reflux disease with special reference to recurrence. [Journal Article]
- EEsophagus 2018; 15(4):217-223
- CONCLUSIONS: Laparoscopic Toupet fundoplication for GERD could be performed safely, with a response rate as good as 85%. Compared with non-recurrent cases, preoperative clinical conditions such as esophageal hiatal hernia, reflux esophagitis, and acid reflux time were all advanced in recurrent cases.