- Alleviation effect of conjugated linoleic acid on estradiol benzoate induced fatty liver hemorrhage syndrome in Hy-line male chickens. [Journal Article]J Anim Sci. 2023 Feb 08 [Online ahead of print]JA
- The purpose of this study was to explore whether conjugated linoleic acid (CLA) could alleviate fatty liver hemorrhagic syndrome (FLHS) induced by estradiol benzoate intramuscular injection in laying hens. One hundred male Hy-Line white chickens were randomly divided into two groups, namely, the control (CON) and estradiol benzoate (E) groups, and both groups were fed the same basal diet. After i…
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- Immunohistochemical Expression of BCL-2 in Endometrial Carcinoma and Its Comparison With Hormone Receptor Status and Epidermal Growth Factor. [Journal Article]Cureus. 2023 Jan; 15(1):e33346.C
- CONCLUSIONS: The positive expressions of estrogen receptor (ER) and progesterone receptor (PR) in endometrial carcinoma suggest that steroid receptor studies may be of potential benefit in the management of some patients with endometrial carcinoma.
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- Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases. [Review]Biol Sex Differ. 2023 Feb 07; 14(1):4.BS
- Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only …
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- Oestrogen receptor variants linked to AD traits. [Journal Article]Nat Rev Neurol. 2023 Feb 07 [Online ahead of print]NR
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- Effects of perinatal exposure to bisphenol A or S in EAE model of multiple sclerosis. [Journal Article]Cell Tissue Res. 2023 Feb 08 [Online ahead of print]CT
- Epidemiological studies support the idea that multiple sclerosis (MS) is a multifactorial disease, overlapping genetic, epigenetic, and environmental factors. A better definition of environmental risks is critical to understand both etiology and the sex-related differences of MS. Exposure to endocrine-disrupting compounds (EDCs) fully represents one of these risks. EDCs are natural or synthetic e…
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- Vaginal bleeding in a newborn as initial presentation of uterus didelphys. [Journal Article]BMJ Case Rep. 2023 Feb 07; 16(2)BC
- Vaginal bleeding of the newborn is described as a normal phenomenon, occurring physiologically in a subset of baby girls as a response to decreased oestrogen levels in the postnatal period compared with in utero exposure. Here, we present the case of heavy vaginal bleeding prompting an evaluation via transabdominal ultrasound, which was ultimately diagnostic for uterus didelphys. We suggest that …
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- Testosterone enhances taurine synthesis by upregulating androgen receptor (AR) and cysteine sulfinic acid decarboxylase (CSAD) expression in male mouse liver. [Journal Article]Am J Physiol Gastrointest Liver Physiol. 2023 Feb 07 [Online ahead of print]AJ
- Taurine is an end-product of cysteine metabolism, while cysteine dioxygenase (CDO) and cysteine sulfinate decarboxylase (CSAD) are key enzymes regulating taurine synthesis. Sex steroids, including estrogens and androgens, are associated with liver physio-pathological processes, however, we still do not know whether taurine and sex steroids interact in regulating liver physiology and hepatic disea…
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- Management of Menopausal Symptoms: A Review. [Journal Article]JAMA. 2023 Feb 07; 329(5):405-420.JAMA
- CONCLUSIONS: During the menopausal transition, approximately 50% to 75% of women have vasomotor symptoms and GSM symptoms. Hormonal therapy with estrogen is the first-line therapy for bothersome vasomotor symptoms and GSM symptoms, but nonhormonal medications (such as paroxetine and venlafaxine) also can be effective. Hormone therapy is not indicated for the prevention of cardiovascular disease.
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- The diagnostic value of transvaginal color Doppler ultrasonography plus serum β-HCG dynamic monitoring in intrauterine residue after medical abortion. [Journal Article]Medicine (Baltimore). 2023 Feb 03; 102(5):e31217.M
- To probe the diagnostic value of transvaginal color Doppler ultrasonography plus serum β-human chorionic gonadotropin (β-HCG) dynamic monitoring in intrauterine residue after medical abortion.In total, 200 pregnant women undergoing medical abortion in our institution from January 2017 to December 2019 were picked, and assigned to either group A (n = 75, with residue) or group B (n = 125, without …
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- Intra‑LPGi microinjection of glutamate receptors antagonists abolish 17β‑estradiol‑induced analgesic effect in the ovariectomized rats. [Journal Article]Acta Neurobiol Exp (Wars). 2022; 82(4):521-533.AN
- This study was designed to investigate a possible interaction between 17β‑estradiol and glutamate receptors of the paragigantocellularis lateralis (LPGi) nucleus on pain coping behavior using the formalin test in ovariectomized (OVX) rats. The results showed that intra‑LPGi injection of 17β‑estradiol declined flexing behavior in both phases of the formalin test. Still, it only diminished the late…
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- Photoredox-catalyzed trifluoromethylation of 2H-indazoles using TT-CF3+OTf- in ionic liquids. [Journal Article]Org Biomol Chem. 2023 Feb 07 [Online ahead of print]OB
- A protocol for metal and oxidant free photoredox catalyzed trifluoromethylation of 2H-indazoles was developed by using Eosin Y as the photocatalyst and recoverable ionic liquids as the solvents. A series of trifluoromethylated products were obtained in moderate to good yields in this protocol under mild conditions. The reaction proceeded via a free-radical mechanism with a broad substrate range, …
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- Exploring the CXCR4/CXCR7/CXCL12 axis in primary desmoid tumors. [Journal Article]Anticancer Agents Med Chem. 2023 Feb 07 [Online ahead of print]AA
- CONCLUSIONS: It is the first time, as per our knowledge, that CXCR4/CXCR7/CXCL12 axis expression has been identified in a desmoid type-fibromatosis series. CXCL12 expression by neoplastic cells, together with CXCR4 and CXCR7 expression by a subgroup of tumor-associated vessels, was detected in all desmoid tumor tissue samples examined. Since chemokines are known contributors to neovascularization, CXCR4/CXCR7/CXCL12 axis may play a role in angiogenesis in this soft-tissue tumor histotype, thereby supporting its growth.
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- 2,3-Diarylindoles as COX-2 inhibitors: exploring the structure-activity relationship through molecular docking simulations. [Journal Article]Curr Top Med Chem. 2023 Feb 07 [Online ahead of print]CT
- CONCLUSIONS: Therefore, such structural features can be used as support for further Structural-Based Drug Design (SBDD) and/or Ligand-Based Drug Design (LBDD) studies on new selective COX-2 inhibitors.
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- Cardio-Metabolic Health and HRT in Menopause: Novel Insights in Mitochondrial Biogenesis and RAAS. [Journal Article]Curr Cardiol Rev. 2023 Feb 06 [Online ahead of print]CC
- Recent evidence shows the cardiometabolic effects of estrogen administration in postmenopausal women. Women have a cardiometabolic advantage during their reproductive years, which is lost at menopause due to declining estradiol (E2). E2, also known as 17-beta-estradiol, has diverse effects in its target tissues, including the cardiovascular (CV) system, through genomic and non-genomic signaling. …
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- Canonical analysis of concentrations of toxic metals in endometrium of women with gynecological disorders. [Journal Article]Ginekol Pol. 2022; 93(10):806-810.GP
- CONCLUSIONS: Endometrium may accumulate toxic metals such as: Pb, Cd, Ni, Mn, Cu, Zn, Al, Cr. It can be assumed that there are characteristic distributions of toxic metals concentrations for individual histopathological diagnoses.
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- Neo-natal castration leads to subtle differences in porcine anterior cruciate ligament morphology and function in adolescence. [Preprint]bioRxiv. 2023 Jan 25B
- Female adolescent athletes are at a higher risk of tearing their anterior cruciate ligament (ACL) than male counterparts. While most work related to hormones has focused on the effects of estrogen to understand the increased risk of ACL injury, there are other understudied factors, including testosterone. The purpose of this study was to determine how surgical castration in the male porcine model…
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- Loss of genital epithelial barrier function is greater with depot-medroxyprogesterone acetate than intravaginal rings that release etonogestrel and ethinyl estradiol. [Preprint]bioRxiv. 2023 Jan 25B
- The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibility to genital infection. The intravaginal ring NuvaRing® is another contraceptive option that like DMPA suppresses hypothalamic pituitary ovarian (HPO) axis fu…
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- Whole exome sequencing and replication for breast cancer among Hispanic/Latino women identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer. [Preprint]medRxiv. 2023 Jan 28M
- CONCLUSIONS: In H/L women, LoF variants in FANCM were strongly associated with ER-negative breast cancer risk. It previously was proposed as a possible susceptibility gene for ER-negative BC, but is not routinely tested in clinical practice. Our results demonstrate that FANCM should be added to BC gene panels.
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- Feeding Neurons Integrate Metabolic and Reproductive States in Mice. [Preprint]bioRxiv. 2023 Jan 26B
- Trade-offs between metabolic and reproductive processes are important for survival, particularly in mammals that gestate their young. Puberty and reproduction, as energetically taxing life stages, are often gated by metabolic availability in animals with ovaries. How the nervous system coordinates these trade-offs is an active area of study. We identify somatostatin neurons of the tuberal nucleus…
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- Estrogen receptor targeting with genistein radiolabeled Technetium-99m as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation. [Journal Article]Heliyon. 2023 Feb; 9(2):e13169.H
- CONCLUSIONS: As a result, [99mTc]Tc-genistein could be a potential radiotracer kit for SPECT imaging of breast cancer.
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- Reduction of daily-use parabens and phthalates reverses accumulation of cancer-associated phenotypes within disease-free breast tissue of study subjects. [Journal Article]Chemosphere. 2023 Feb 04 [Online ahead of print]C
- Estrogenic overstimulation is carcinogenic to the human breast. Personal care products (PCPs) commonly contain xenoestrogens (XE), such as parabens and phthalates. Here, we identified the adverse effects of persistent exposure to such PCPs directly within human estrogen responsive breast tissue of subjects enrolled in a regimen of reduced XE use (REDUXE). Pre- and post-intervention fine needle as…
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- ERα stimulation rapidly modulates excitatory synapse properties in female rat nucleus accumbens core. [Journal Article]Neuroendocrinology. 2023 Feb 06 [Online ahead of print]N
- CONCLUSIONS: These data provide evidence that activation of ERα is sufficient for inducing changes in mEPSC frequency, and a likely candidate underlying the estradiol-induced changes observed during the estrous cycle. Overall, these findings extend our understanding of the neuroendocrinology of the NAcc and implicate ERα as a primary target for future studies.
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- Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways. [Journal Article]Biomed Pharmacother. 2023 Feb 04; 160:114347.BP
- The formation of osteoclasts and their hyperactive bone resorption are related to the aggregation of intracellular reactive oxygen species (ROS). Flavonoids, derived from plant active ingredients, can alleviate the symptoms of osteoporosis (OP). Isosinensetin (Iss) is a flavonoid with antioxidant effects obtained mainly from citrus fruits, and its effect on osteoclastogenesis has not been reporte…
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- Gallstone Pancreatitis Post-Cesarean Section: A Case Report. [Journal Article]S D Med. 2022 Aug; 75(suppl 8):s20.SD
- Acute gallstone pancreatitis is a rare occurrence in pregnancy and the postpartum period. However, gallstone pancreatitis should be considered in a differential diagnosis for right upper quadrant (RUQ) pain in this population, as the risk of biliary stasis and gallstone formation increases in pregnancy due to high levels of circulating estrogen causing increased cholesterol formation and delayed …
- Vitamin D and estrogen steroid hormones and their immunogenetic roles in Infectious respiratory (TB and COVID-19) diseases. [Journal Article]Genet Mol Biol. 2023; 46(1 Suppl 2):e20220158.GM
- The role of steroid hormones against infectious diseases has been extensively studied. From immunomodulatory action to direct inhibition of microorganism growth, hormones D3 (VD3) and 17β-estradiol (E2), and the genetic pathways modulated by them, are key targets for a better understanding pathogenesis of infectious respiratory diseases (IRD) such as tuberculosis (TB) and the coronavirus disease-…
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- Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study. [Journal Article]PLoS One. 2023; 18(2):e0281218.Plos
- CONCLUSIONS: The CAMO cohort provides data suitable for epidemiological, clinical, molecular, and multi-omics investigations, thereby enabling a systems epidemiology approach to translational breast cancer research.
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- ASO Visual Abstract: Local-Regional Recurrence Following Neoadjuvant Endocrine Therapy - Data from ACOSOG Z1031 (Alliance), a Randomized Phase II Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women with Estrogen Receptor-Positive Clinical Stage 2-3 Breast Cancer. [Journal Article]Ann Surg Oncol. 2023 Feb 06 [Online ahead of print]AS
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- Discovery of Targets for Immune-Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha. [Journal Article]Cancer Discov. 2023 Feb 06 [Online ahead of print]CD
- Drugs that kill tumors through multiple mechanisms have the potential for broad clinical benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer cell-specific regulators that simultaneously modulate tumor immunity and another oncogenic pathway and then used it to identify 38 candidate immune-metabolic regulators. We show the tumor activities of these regulat…
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- Therapeutic potential of thiophene compounds: a mini-review. [Journal Article]Mini Rev Med Chem. 2023 Feb 06 [Online ahead of print]MR
- A rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial li…
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- Pharmacological and metabolic effects of drospirenone as a progestin-only pill compared to combined formulations with estrogen. [Review]Womens Health (Lond). 2023 Jan-Dec; 19:17455057221147388.WH
- The spironolactone derivative drospirenone is combined with ethinylestradiol or estetrol in combined oral contraceptives. Formulations with 17-β-estradiol are used to treat climacteric symptoms. A drospirenone-only formulation has been introduced for contraception. Here, the pharmacological properties of drospirenone, the impact of the different formulations on metabolic and laboratory parameters…
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