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Unbound Medicine.
(Estrogens)
287,429 results
  • Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases. [Review]
    Biol Sex Differ. 2023 Feb 07; 14(1):4.Santos-Marcos JA, Mora-Ortiz M, … Camargo A
  • Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only …
  • Effects of perinatal exposure to bisphenol A or S in EAE model of multiple sclerosis. [Journal Article]
    Cell Tissue Res. 2023 Feb 08 [Online ahead of print]Bonaldo B, Casile A, … Marraudino M
  • Epidemiological studies support the idea that multiple sclerosis (MS) is a multifactorial disease, overlapping genetic, epigenetic, and environmental factors. A better definition of environmental risks is critical to understand both etiology and the sex-related differences of MS. Exposure to endocrine-disrupting compounds (EDCs) fully represents one of these risks. EDCs are natural or synthetic e…
  • Vaginal bleeding in a newborn as initial presentation of uterus didelphys. [Journal Article]
    BMJ Case Rep. 2023 Feb 07; 16(2)Saleh F, Gaeta ML, … Vash-Margita A
  • Vaginal bleeding of the newborn is described as a normal phenomenon, occurring physiologically in a subset of baby girls as a response to decreased oestrogen levels in the postnatal period compared with in utero exposure. Here, we present the case of heavy vaginal bleeding prompting an evaluation via transabdominal ultrasound, which was ultimately diagnostic for uterus didelphys. We suggest that …
  • Management of Menopausal Symptoms: A Review. [Journal Article]
    JAMA. 2023 Feb 07; 329(5):405-420.Crandall CJ, Mehta JM, Manson JE
  • CONCLUSIONS: During the menopausal transition, approximately 50% to 75% of women have vasomotor symptoms and GSM symptoms. Hormonal therapy with estrogen is the first-line therapy for bothersome vasomotor symptoms and GSM symptoms, but nonhormonal medications (such as paroxetine and venlafaxine) also can be effective. Hormone therapy is not indicated for the prevention of cardiovascular disease.
  • Photoredox-catalyzed trifluoromethylation of 2H-indazoles using TT-CF3+OTf- in ionic liquids. [Journal Article]
    Org Biomol Chem. 2023 Feb 07 [Online ahead of print]He X, Chen Z, … Chu W
  • A protocol for metal and oxidant free photoredox catalyzed trifluoromethylation of 2H-indazoles was developed by using Eosin Y as the photocatalyst and recoverable ionic liquids as the solvents. A series of trifluoromethylated products were obtained in moderate to good yields in this protocol under mild conditions. The reaction proceeded via a free-radical mechanism with a broad substrate range, …
  • Exploring the CXCR4/CXCR7/CXCL12 axis in primary desmoid tumors. [Journal Article]
    Anticancer Agents Med Chem. 2023 Feb 07 [Online ahead of print]Baccalini EA, Renne SL, … Borronid EM
  • CONCLUSIONS: It is the first time, as per our knowledge, that CXCR4/CXCR7/CXCL12 axis expression has been identified in a desmoid type-fibromatosis series. CXCL12 expression by neoplastic cells, together with CXCR4 and CXCR7 expression by a subgroup of tumor-associated vessels, was detected in all desmoid tumor tissue samples examined. Since chemokines are known contributors to neovascularization, CXCR4/CXCR7/CXCL12 axis may play a role in angiogenesis in this soft-tissue tumor histotype, thereby supporting its growth.
  • Cardio-Metabolic Health and HRT in Menopause: Novel Insights in Mitochondrial Biogenesis and RAAS. [Journal Article]
    Curr Cardiol Rev. 2023 Feb 06 [Online ahead of print]Renke G, Kemen E, … Pereira MB
  • Recent evidence shows the cardiometabolic effects of estrogen administration in postmenopausal women. Women have a cardiometabolic advantage during their reproductive years, which is lost at menopause due to declining estradiol (E2). E2, also known as 17-beta-estradiol, has diverse effects in its target tissues, including the cardiovascular (CV) system, through genomic and non-genomic signaling. …
  • Feeding Neurons Integrate Metabolic and Reproductive States in Mice. [Preprint]
    bioRxiv. 2023 Jan 26Massa MG, Scott RL, … Correa SM
  • Trade-offs between metabolic and reproductive processes are important for survival, particularly in mammals that gestate their young. Puberty and reproduction, as energetically taxing life stages, are often gated by metabolic availability in animals with ovaries. How the nervous system coordinates these trade-offs is an active area of study. We identify somatostatin neurons of the tuberal nucleus…
  • Gallstone Pancreatitis Post-Cesarean Section: A Case Report. [Journal Article]
    S D Med. 2022 Aug; 75(suppl 8):s20.Chandra S, Kappenman A
  • Acute gallstone pancreatitis is a rare occurrence in pregnancy and the postpartum period. However, gallstone pancreatitis should be considered in a differential diagnosis for right upper quadrant (RUQ) pain in this population, as the risk of biliary stasis and gallstone formation increases in pregnancy due to high levels of circulating estrogen causing increased cholesterol formation and delayed …
  • Discovery of Targets for Immune-Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha. [Journal Article]
    Cancer Discov. 2023 Feb 06 [Online ahead of print]Sahu A, Wang X, … Flaherty KT
  • Drugs that kill tumors through multiple mechanisms have the potential for broad clinical benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer cell-specific regulators that simultaneously modulate tumor immunity and another oncogenic pathway and then used it to identify 38 candidate immune-metabolic regulators. We show the tumor activities of these regulat…
  • Therapeutic potential of thiophene compounds: a mini-review. [Journal Article]
    Mini Rev Med Chem. 2023 Feb 06 [Online ahead of print]Chawla S, Sharma S, … Sapra A
  • A rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial li…
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