- Evaluating dermatology education in Australia: Medical students' and junior doctors' perceptions. [Journal Article]Australas J Dermatol. 2023 Feb 08 [Online ahead of print]AJ
- CONCLUSIONS: Final-phase medical students and junior doctors exhibit low confidence across many dermatology competencies. Participants believed they need more dermatology education, and seldom feel prepared when exposed to dermatologic pathologies. Introduction of a standardised curriculum, formal assessments and increased clinical exposure are possible solutions.
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- 'Some of my patients only come to renew their prescriptions. They are not interested in any additional advice or support'. Physicians' perceptions on their roles in cardiovascular diseases risk reduction and management in Fiji. [Journal Article]Prim Health Care Res Dev. 2023 Feb 08; 24:e11.PH
- CONCLUSIONS: Physicians' perceptions on their commitment to prevention and management of CVDs through their skills and knowledge, beliefs and motivation should be acknowledged. It is recommended that the physicians are updated on the current evidence-based medicine. Limitations include results that may not be the reflection of the entire physician and multidisciplinary community and the difficulties in face-to-face interviews due to the coronavirus diseases of 2019 pandemic.
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- Highly cited forensic practitioners in the Nordic countries and their composite citation scores based on six different citation metrics. [Journal Article]Med Leg J. 2023 Feb 08 [Online ahead of print]ML
- Forensic science is a multidisciplinary field that involves the use of various scientific methods and techniques for the investigation of crimes. Forensic scientists are often required to testify in court as expert witnesses and explain the meaning of chemical, physical, and/or medical evidence to a judge and jury. This article took advantage of a citation database to identify the most highly cit…
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- Real-world study of next-generation sequencing diagnostic biomarker testing for patients with lung cancer in Japan. [Journal Article]Cancer Sci. 2023 Feb 08 [Online ahead of print]CS
- Our previous real-world studies raised concerns that sequential biomarker testing may lead to increased time to treatment when compared with simultaneous single biomarker testing. The Oncomine Dx target test (ODxTT), a next-generation sequencing-based multiplex biomarker panel test approved in Japan in 2019, is expected to improve time to treatment due to changes in testing methods. This retrospe…
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- High consumption of unhealthy commercial foods and beverages tracks across the complementary feeding period in rural/peri-urban Cambodia. [Journal Article]Matern Child Nutr. 2023 Feb 08 [Online ahead of print]MC
- Consumption of unhealthy commercial foods and beverages (UCFB) is common among infants and young children living in low- and middle-income countries. Such foods can displace other nutritious foods, however, there is limited evidence on how this consumption tracks across time. This study assessed and tracked UCFB consumption of children living in rural/peri-urban Cambodia during the complementary …
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- Clinical Pathways for the Identification and Referral for Social Needs: A Systematic Review. [Journal Article]Pediatrics. 2023 Feb 08 [Online ahead of print]Ped
- CONCLUSIONS: Despite evidence that clinical pathways for children and families help reduce social needs, evidence for improvements in child health is insufficient. Further studies from diverse settings are needed to inform clinical practice to optimize child health outcomes.
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- Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B, endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society. [Journal Article]J Zhejiang Univ Sci B. 2023 Feb 15; 24(2):130-142.JZ
- Polymyxin B, which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections, became available in China in Dec. 2017. As dose adjustments are based solely on clinical experience of risk toxicity, treatment failure, and emergence of resistance, there is an urgent clinical need to perform therapeutic drug monitoring (TDM) to optimize the use of polymyxin B. It is t…
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- Comparing Complication Rates of Midline Catheter vs Peripherally Inserted Central Catheter. A Systematic Review and Meta-analysis. [Journal Article]Open Forum Infect Dis. 2023 Feb; 10(2):ofad024.OF
- CONCLUSIONS: Our findings suggest that patients who use midlines might experience fewer CRBSIs than those who use PICCs. However, the use of midline catheters was associated with greater risk of superficial vein thrombosis. These findings can help guide future cost-benefit analyses and direct comparative RCTs to further characterize the efficacy and risks of PICCs vs midline catheters.
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- Effect of a ward-based outreach team and adherence game on retention and viral load suppression. [Journal Article]South Afr J HIV Med. 2022; 23(1):1446.SA
- CONCLUSIONS: This study demonstrated that an adherence game intervention could help keep PLWH in care.
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- Predicting neurosurgical referral outcomes in patients with chronic subdural hematomas using machine learning algorithms - A multi-center feasibility study. [Journal Article]Surg Neurol Int. 2023; 14:22.SN
- CONCLUSIONS: ML models can accurately predict referral outcomes and can potentially be used in clinical practice as CSDH referral decision making support tools. The growing demand in healthcare, combined with increasing digitization of health records raises the opportunity for ML algorithms to be used for decision making in complex clinical scenarios.
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- A Quantification Method for Disorganized Bone Components: Application to the Femoral Shaft. [Journal Article]JBMR Plus. 2023 Feb; 7(2):e10713.JP
- Based on the current paradigm, a healthy bone is one with adequate mass without microarchitectural decay. However, these two features may not be sufficient to ensure that a bone is healthy. In addition, components must be correctly assembled and aligned. This ensures "the right amount of bone, at the right place" and thus, an optimal cohesion or interplay between constituents. Disorganization may…
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- Cutaneous angiosarcoma treated with taxane-based chemoradiotherapy: A multicenter study of 90 Japanese cases. [Journal Article]Skin Health Dis. 2023 Feb; 3(1):e180.SH
- Cutaneous angiosarcoma (CAS) is rare and most previous studies of CAS have been small case series, and randomized, phase II studies of CAS are limited. Since treatment options for CAS are controversial, and because only paclitaxel should be recommended based on high-level evidence, it is important to evaluate the efficacy of another taxane-derived agents, docetaxel, in real-world practice. The ef…
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- Methods used for indirect comparisons of systemic treatments for psoriasis. A systematic review. [Review]Skin Health Dis. 2023 Feb; 3(1):e112.SH
- CONCLUSIONS: Understanding that there are different methodologies employed to answer differing research questions is key to helping clinicians to interpret the indirect evidence currently available in psoriasis.
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- The Saudi Consensus for the Management of Cancer-Associated Thromboembolism: A Modified Delphi-Based Study. [Journal Article]TH Open. 2023 Jan; 7(1):e14-e29.TO
- Background Cancer is a well-known risk factor of preventable thromboembolic disease. This study aims to provide guidance on the prevention and management of cancer-associated thrombosis (CT) that tailors prophylactic and therapeutic options for medical and surgical oncology patients presenting to health care settings in Saudi Arabia. Methods The present consensus was developed in concordance wi…
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- Korean Guidelines for Postpolypectomy Colonoscopic Surveillance: 2022 revised edition. [Review]Intest Res. 2023 Jan; 21(1):20-42.IR
- Colonoscopic polypectomy is effective in decreasing the incidence and mortality of colorectal cancer (CRC). Premalignant polyps discovered during colonoscopy are associated with the risk of metachronous advanced neoplasia. Postpolypectomy surveillance is the most important method for managing advanced metachronous neoplasia. A more efficient and evidence-based guideline for postpolypectomy survei…
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- Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach. [Review]J Gastric Cancer. 2023 Jan; 23(1):3-106.JG
- Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this is the 4th gastric cancer guideline published in Korea which is the revised version of previous evidence-based approach in 2018. Current guideline is a collaborative work of the interdisciplinary working group including experts in the field of gastric surgery, gastroenterology, endoscopy, medical oncology, a…
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- Acceptance and commitment therapy for people with acquired brain injury: Rationale and description of the BrainACT treatment. [Journal Article]Clin Rehabil. 2023 Feb 07 [Online ahead of print]CR
- CONCLUSIONS: Existing evidence-based protocols were adapted for the needs and potential cognitive deficits after brain injury. General alterations are the use of visual materials, summaries and repetition. Acceptance and commitment therapy-specific adaptions include the Bus of Life metaphor as a recurrent exercise, shorter mindfulness exercises, simplified explanations, a focus on experiential exercises and the monitoring of committed actions. The intervention consists of eight one-hour sessions with a psychologist, experienced in acceptance and commitment therapy and in working with people with acquired brain injury. The order of the sessions, metaphors and exercises can be tailored to the needs of the patients.Currently, the effectiveness and feasibility of the intervention is evaluated in a randomised controlled trial. The BrainACT intervention is expected to be a feasible and effective intervention for people with anxiety or depressive symptoms following acquired brain injury.
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- Using a patient-centred composite endpoint in a secondary analysis of the Control of Hypertension in Pregnancy Study (CHIPS) Trial. [Journal Article]Trials. 2023 Feb 07; 24(1):99.T
- CONCLUSIONS: Evidence-based recommendations for 'tight' control are consistent with most women's preferences, but for a sixth of women, 'less-tight' control is more preference consistent. Depending on patient preferences, a single trial may support different interventions. Future trials should specify component weights to improve interpretation.
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- Informed or misinformed consent and use of modified texture diets in dysphagia. [Journal Article]BMC Med Ethics. 2023 Feb 07; 24(1):7.BM
- CONCLUSIONS: Research is required to examine the informed consent processes in different settings, but there is ample reason to suggest that current practice in this area is suboptimal. Staff need to reflect on their current practice regarding use of modified texture diets with an awareness of the current evidence and through the 'lens' of informed consent. Education is required for staff to clarify the importance of, and requirements for, valid informed consent and for decision making that reflects people's preferences and values.
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- Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial. [Journal Article]Trials. 2023 Feb 07; 24(1):94.T
- CONCLUSIONS: The results of this research may help in the real understanding of the nutritional compounds capable of generating safety to the cardiovascular system during physical exercise, especially for women who are aging and who have cardiovascular limitations (e.g., arterial hypertension) to perform physical exercise. Therefore, our results will be able to help specific nutritional recommendations to optimize cardiovascular health.
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- New frontiers in healthcare environmental hygiene: thoughts from the 2022 healthcare cleaning forum. [Journal Article]Antimicrob Resist Infect Control. 2023 Feb 07; 12(1):7.AR
- Healthcare environmental hygiene (HEH) has become recognized as being increasingly important for patient safety and the prevention of healthcare-associated infections. At the 2022 Healthcare Cleaning Forum at Interclean in Amsterdam, the academic lectures focused on a series of main areas of interest. These areas are indicative of some of the main trends and avenues for research in the coming yea…
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- Comparative short-term effectiveness of non-surgical treatments for insertional Achilles tendinopathy: a systematic review and network meta-analysis. [Journal Article]BMC Musculoskelet Disord. 2023 Feb 07; 24(1):102.BM
- CONCLUSIONS: This is the first NMA of non-surgical treatment focusing on short-term pain control for IAT which eccentric exercise plus soft-tissue therapy was found to be the most effective treatment combination. However, the overall confidence in non-surgical treatments from all included trials was very low. No recommendation of the best treatment option can be made from this review.
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- Evaluating student's ability to assess treatment claims: validating a German version of the Claim Evaluation Tools. [Journal Article]BMC Public Health. 2023 Feb 07; 23(1):262.BP
- CONCLUSIONS: After the revision of some items, the questionnaires are suitable to evaluate secondary school students' ability to assess health claims. A future goal is to increase the pool of items being translated and tested.
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- Minimal clinically important difference of the functional independence measure in older adults with hip fracture. [Journal Article]Disabil Rehabil. 2023 Feb 07 [Online ahead of print]DR
- CONCLUSIONS: The FIM scale is appropriate for assessing independence and functional recovery in hip-fractured elderly. Improvements of 22 and 21 points at the total and motor FIM were identified as indicators of minimal clinical change in those admitted to a rehabilitation facility with an FIM total score between 40 and 80.Implications for rehabilitationThis study provides evidence of the high responsiveness of the Functional Independence Measure (FIM) total score and of its motor subscore, while the cognitive subscore is not responsive to change among older adults with hip fractures hospitalized for rehabilitation.After a rehabilitative program, a change of at least 22 points in the FIM total score is clinically important in older adults with hip fractures.This change scores will be useful for researchers and clinicians in order to determine a possible clinically meaningful improvement in independence as a response to rehabilitation after a hip fracture.
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- A sex-specific genome-wide association study of depression phenotypes in UK Biobank. [Journal Article]Mol Psychiatry. 2023 Feb 07 [Online ahead of print]MP
- There are marked sex differences in the prevalence, phenotypic presentation and treatment response for major depression. While genome-wide association studies (GWAS) adjust for sex differences, to date, no studies seek to identify sex-specific markers and pathways. In this study, we performed a sex-stratified genome-wide association analysis for broad depression with the UK Biobank total particip…
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- Molecular mechanisms of miR-1236 in the assessment of tumor lymphangiogenesis in human ovarian cancer patients. [Journal Article]J Gene Med. 2023 Feb 07 [Online ahead of print]JG
- CONCLUSIONS: Our results provide evidence for the translational involvement of miR-1236 in the lymphangiogenesis of OC by regulating lymphangiogenesis-related factors and support the clinical importance of miR-1236 as a new diagnostic and prognostic biomarker for OC.
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- Monkeypox-induced proctitis: a case report of an emerging complication. [Journal Article]Infection. 2023 Feb 07 [Online ahead of print]I
- CONCLUSIONS: As more cases of monkeypox-associated proctitis emerge, clinicians should keep this disease in their differential due to the growing atypical presentations that have diverged from previous patterns to avoid the risk of misdiagnosing another sexually transmitted infection. Additionally, appropriate medical management is still not definitive and requires further development of evidence-based protocols to treat such patients.
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- Outcomes of acute perilunate injuries-a systematic review. [Review]Eur J Trauma Emerg Surg. 2023 Feb 07 [Online ahead of print]EJ
- CONCLUSIONS: Regardless of surgical technique, PLFDs appear to be less susceptible to secondary reduction loss than PLDs. Whenever possible, less invasive (e.g. arthroscopic) surgery should be performed to minimize postoperative complications. The rate of rOA is high and increases significantly with follow-up duration. Interestingly, rOA does not seem to correlate with reduced wrist function nor patient dissatisfaction and the need for salvage surgery is surprisingly rare.
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- Traumatic Posterior Atlantoaxial Dislocation With an Associated Fracture: A Systematic Review. [Journal Article]Clin Spine Surg. 2023 Feb 03 [Online ahead of print]CS
- CONCLUSIONS: TPAD with fracture occurred in the majority of cases with Anderson and D'alonzo type II odontoid fracture, predominantly in males. Diagnosis is usually established based on computed tomography imaging; further imaging may not be indicated as it does not seem to alternate the patient's management course. Surgical intervention was employed in almost all cases, with favored results through posterior C1-C2 fusion.
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- Cephalomedullary Nailing of Unstable Geriatric Intertrochanteric Fractures on a Traction Table Combined with Percutaneous Reduction Techniques is Safe and Results in a Low Rate of Cut-out. [Journal Article]J Orthop Trauma. 2023 Jan 26 [Online ahead of print]JO
- CONCLUSIONS: The current study suggests utilization of accessory incisions assist in reduction is safe and is associated with a low rate of complications. The surgeon should prioritize fracturereduction and optimal implant placement and not hesitate to utilize an accessory incision to assist with fracture reduction.
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