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Unbound Medicine.
(Evidence based medicine)
253,437 results
  • Evaluating dermatology education in Australia: Medical students' and junior doctors' perceptions. [Journal Article]
    Australas J Dermatol. 2023 Feb 08 [Online ahead of print]Ireland P, Rosen R, … Rosen R
  • CONCLUSIONS: Final-phase medical students and junior doctors exhibit low confidence across many dermatology competencies. Participants believed they need more dermatology education, and seldom feel prepared when exposed to dermatologic pathologies. Introduction of a standardised curriculum, formal assessments and increased clinical exposure are possible solutions.
  • A Quantification Method for Disorganized Bone Components: Application to the Femoral Shaft. [Journal Article]
    JBMR Plus. 2023 Feb; 7(2):e10713.Zebaze R, Shore-Lorenti C, … Ebeling PR
  • Based on the current paradigm, a healthy bone is one with adequate mass without microarchitectural decay. However, these two features may not be sufficient to ensure that a bone is healthy. In addition, components must be correctly assembled and aligned. This ensures "the right amount of bone, at the right place" and thus, an optimal cohesion or interplay between constituents. Disorganization may…
  • Korean Guidelines for Postpolypectomy Colonoscopic Surveillance: 2022 revised edition. [Review]
    Intest Res. 2023 Jan; 21(1):20-42.Kim SY, Kwak MS, … Korean Association for the Study of Intestinal Diseases
  • Colonoscopic polypectomy is effective in decreasing the incidence and mortality of colorectal cancer (CRC). Premalignant polyps discovered during colonoscopy are associated with the risk of metachronous advanced neoplasia. Postpolypectomy surveillance is the most important method for managing advanced metachronous neoplasia. A more efficient and evidence-based guideline for postpolypectomy survei…
  • Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach. [Review]
    J Gastric Cancer. 2023 Jan; 23(1):3-106.Kim TH, Kim IH, … Development Working Groups for the Korean Practice Guidelines for Gastric Cancer 2022 Task Force Team
  • Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this is the 4th gastric cancer guideline published in Korea which is the revised version of previous evidence-based approach in 2018. Current guideline is a collaborative work of the interdisciplinary working group including experts in the field of gastric surgery, gastroenterology, endoscopy, medical oncology, a…
  • Acceptance and commitment therapy for people with acquired brain injury: Rationale and description of the BrainACT treatment. [Journal Article]
    Clin Rehabil. 2023 Feb 07 [Online ahead of print]Rauwenhoff JCC, Bol Y, … Peeters F
  • CONCLUSIONS: Existing evidence-based protocols were adapted for the needs and potential cognitive deficits after brain injury. General alterations are the use of visual materials, summaries and repetition. Acceptance and commitment therapy-specific adaptions include the Bus of Life metaphor as a recurrent exercise, shorter mindfulness exercises, simplified explanations, a focus on experiential exercises and the monitoring of committed actions. The intervention consists of eight one-hour sessions with a psychologist, experienced in acceptance and commitment therapy and in working with people with acquired brain injury. The order of the sessions, metaphors and exercises can be tailored to the needs of the patients.Currently, the effectiveness and feasibility of the intervention is evaluated in a randomised controlled trial. The BrainACT intervention is expected to be a feasible and effective intervention for people with anxiety or depressive symptoms following acquired brain injury.
  • Informed or misinformed consent and use of modified texture diets in dysphagia. [Journal Article]
    BMC Med Ethics. 2023 Feb 07; 24(1):7.O'Keeffe ST, Leslie P, … SPARC (Swallow Perspectives, Advocacy and Research Collective)
  • CONCLUSIONS: Research is required to examine the informed consent processes in different settings, but there is ample reason to suggest that current practice in this area is suboptimal. Staff need to reflect on their current practice regarding use of modified texture diets with an awareness of the current evidence and through the 'lens' of informed consent. Education is required for staff to clarify the importance of, and requirements for, valid informed consent and for decision making that reflects people's preferences and values.
  • New frontiers in healthcare environmental hygiene: thoughts from the 2022 healthcare cleaning forum. [Journal Article]
    Antimicrob Resist Infect Control. 2023 Feb 07; 12(1):7.Peters A, Parneix P, … Pittet D
  • Healthcare environmental hygiene (HEH) has become recognized as being increasingly important for patient safety and the prevention of healthcare-associated infections. At the 2022 Healthcare Cleaning Forum at Interclean in Amsterdam, the academic lectures focused on a series of main areas of interest. These areas are indicative of some of the main trends and avenues for research in the coming yea…
  • Minimal clinically important difference of the functional independence measure in older adults with hip fracture. [Journal Article]
    Disabil Rehabil. 2023 Feb 07 [Online ahead of print]Arcolin I, Godi M, … Corna S
  • CONCLUSIONS: The FIM scale is appropriate for assessing independence and functional recovery in hip-fractured elderly. Improvements of 22 and 21 points at the total and motor FIM were identified as indicators of minimal clinical change in those admitted to a rehabilitation facility with an FIM total score between 40 and 80.Implications for rehabilitationThis study provides evidence of the high responsiveness of the Functional Independence Measure (FIM) total score and of its motor subscore, while the cognitive subscore is not responsive to change among older adults with hip fractures hospitalized for rehabilitation.After a rehabilitative program, a change of at least 22 points in the FIM total score is clinically important in older adults with hip fractures.This change scores will be useful for researchers and clinicians in order to determine a possible clinically meaningful improvement in independence as a response to rehabilitation after a hip fracture.
  • A sex-specific genome-wide association study of depression phenotypes in UK Biobank. [Journal Article]
    Mol Psychiatry. 2023 Feb 07 [Online ahead of print]Silveira PP, Pokhvisneva I, … Meaney MJ
  • There are marked sex differences in the prevalence, phenotypic presentation and treatment response for major depression. While genome-wide association studies (GWAS) adjust for sex differences, to date, no studies seek to identify sex-specific markers and pathways. In this study, we performed a sex-stratified genome-wide association analysis for broad depression with the UK Biobank total particip…
  • Monkeypox-induced proctitis: a case report of an emerging complication. [Journal Article]
    Infection. 2023 Feb 07 [Online ahead of print]Rathore A, Kahn C, … House JG
  • CONCLUSIONS: As more cases of monkeypox-associated proctitis emerge, clinicians should keep this disease in their differential due to the growing atypical presentations that have diverged from previous patterns to avoid the risk of misdiagnosing another sexually transmitted infection. Additionally, appropriate medical management is still not definitive and requires further development of evidence-based protocols to treat such patients.
  • Outcomes of acute perilunate injuries-a systematic review. [Review]
    Eur J Trauma Emerg Surg. 2023 Feb 07 [Online ahead of print]Liechti R, Merky DN, … Hirsiger S
  • CONCLUSIONS: Regardless of surgical technique, PLFDs appear to be less susceptible to secondary reduction loss than PLDs. Whenever possible, less invasive (e.g. arthroscopic) surgery should be performed to minimize postoperative complications. The rate of rOA is high and increases significantly with follow-up duration. Interestingly, rOA does not seem to correlate with reduced wrist function nor patient dissatisfaction and the need for salvage surgery is surprisingly rare.
  • Traumatic Posterior Atlantoaxial Dislocation With an Associated Fracture: A Systematic Review. [Journal Article]
    Clin Spine Surg. 2023 Feb 03 [Online ahead of print]Essa A, Khatib S, … Rabau O
  • CONCLUSIONS: TPAD with fracture occurred in the majority of cases with Anderson and D'alonzo type II odontoid fracture, predominantly in males. Diagnosis is usually established based on computed tomography imaging; further imaging may not be indicated as it does not seem to alternate the patient's management course. Surgical intervention was employed in almost all cases, with favored results through posterior C1-C2 fusion.
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