- Evaluation of Diffusion Anisotropy and Diffusion Shape in Grading of Glial Tumors. [Journal Article]J Biomed Phys Eng 2019; 9(4):459-464JB
- CONCLUSIONS: Our findings prove significant difference between diffusion anisotropy (FA) and diffusion shape (Cl) between low grade and high grade glioma, based on which we find this evaluation helpful in the grading of glial tumors.
- Malnutrition, nutritional interventions and clinical outcomes of patients with acute small bowel obstruction: results from a national, multicentre, prospective audit. [Journal Article]BMJ Open 2019; 9(7):e029235BO
- CONCLUSIONS: Malnutrition on admission is associated with worse outcomes in patients with SBO, and marked variation in management of malnutrition was observed. Future trials should focus on identifying effective and cost-effective nutritional interventions in SBO.
- Sexual Functioning and Opioid Maintenance Treatment in Women. Results From a Large Multicentre Study. [Journal Article]Front Behav Neurosci 2019; 13:97FB
- Opioid maintenance treatment (OMT) is the most widespread therapy for both females and males opioid addicts. While many studies have evaluated the OMT impact on men's sexuality, the data collected about the change in women's sexual functioning is still limited despite the fact that it is now well-known that opioids - both endogenous and exogenous - affect the endocrine system and play an importan…
Opioid maintenance treatment (OMT) is the most widespread therapy for both females and males opioid addicts. While many studies have evaluated the OMT impact on men's sexuality, the data collected about the change in women's sexual functioning is still limited despite the fact that it is now well-known that opioids - both endogenous and exogenous - affect the endocrine system and play an important role in sexual functioning. The present study aims to determine how OMT with buprenorphine (BUP) or methadone (MTD) affects sexual health in women; examining also any possible emerging correlation between sexual dysfunction (SD), type of opioid and patients' mental health. This multi-center study case recruited 258 female volunteers attending Italian public Addiction Outpatients Centers that were stabilized with OMT for at least 3 months. SD was assessed with the Arizona Sexual Experience Scale. The twelve-item General Health Questionnaire was used to assess participants' mental health conditions. The results show that 56.6% of women receiving OMT for at least 3 months presented SD without significant differences between MTD e BUP groups. The majority of the subjects with SD have a poorer quality of intimate relationships and worse mental health than the average. To the best of our knowledge, the present study is the largest report on the presence of SDs in women as a side effects of MTD and BUP used in OMT. Since SDs cause difficulties in intimate relationships, lower patients' quality of life and interfere with OMT beneficial outcomes, we recommend that women undertaking an opioid therapy have routine screening for SD and we highlight the importance to better examine opioid-endocrine interactions in future studies in order to provide alternative potential treatments such as the choice of opioid, opioid dose reduction and hormone supplementation.
- Cohort profile: design and methods in the eye and vision consortium of UK Biobank. [Journal Article]BMJ Open 2019; 9(2):e025077BO
- To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank.
To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank.
- More than three passes of stent retriever is an independent predictor of parenchymal hematoma in acute ischemic stroke. [Randomized Controlled Trial]J Neurointerv Surg 2019; 11(7):625-629JN
- CONCLUSIONS: After three passes of SR and unlike for three passes of CA, there is an increased risk of PH and a trend toward a worse clinical outcome.
- Susceptibility vessel sign on MRI predicts better clinical outcome in patients with anterior circulation acute stroke treated with stent retriever as first-line strategy. [Randomized Controlled Trial]J Neurointerv Surg 2019; 11(4):328-333JN
- CONCLUSIONS: Based on results for patients of the ASTER and THRACE trials receiving first-line SR treatment, SVS was associated with lower disability at 3 months. Large prospective studies using MRI-based thrombus evaluation are warranted.
- Safety and efficacy of mechanical thrombectomy in acute ischemic stroke of anticoagulated patients. [Journal Article]J Neurointerv Surg 2018; 10(12):e29JN
- CONCLUSIONS: With regard to intracranial bleeding and functional outcome at 3 months, MT in APs seems as safe and efficient as in NAPs. However, there is a higher risk of death at 3 months in the AP-MT group compared with the NAP-IVTMT group.
- Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study. [Multicenter Study]Clin Infect Dis 2017; 64(suppl_3):S317-S327CI
- CONCLUSIONS: Pneumococcal colonization density >6.9 log10 copies/mL was strongly associated with MCPP and could be used to improve estimates of pneumococcal pneumonia prevalence in childhood pneumonia studies. Our findings do not support its use for individual diagnosis in a clinical setting.
- Limited Utility of Polymerase Chain Reaction in Induced Sputum Specimens for Determining the Causes of Childhood Pneumonia in Resource-Poor Settings: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study. [Journal Article]Clin Infect Dis 2017; 64(suppl_3):S289-S300CI
- CONCLUSIONS: Using advanced molecular methods with IS specimens provided little additional diagnostic information beyond that obtained with NP/OP swab specimens.
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- New AHS staffing models cause for concern. [Letter]Alta RN 2013; 69(3):5 discussion 5AR