- Pile-up correction algorithm for high count rate gamma ray spectroscopy. [Journal Article]
- ARAppl Radiat Isot 2019 Jun 05; 151:196-206
- In nuclear applications related to radiation energy measurement, digital pulse processing for fast sampling facility has great advantages compared to the traditional analog pulse processing. A distor…
In nuclear applications related to radiation energy measurement, digital pulse processing for fast sampling facility has great advantages compared to the traditional analog pulse processing. A distortion in energy spectrum and degradation in timing resolution take place when pulse pile-up occurs. This in turn leads to degradations of the signals used in applications such as nuclear medicine. Pile-up pulses are commonly removed in most algorithms if they are detected, but in this case, getting a clean spectrum becomes a challenge due to data loss. A proposed pile-up detection and recovery algorithm based on fitting the preamplifier data and signal extrapolation is presented. The extrapolated pulse is used for recovering (extracting) the piled-up pulse to estimate its parameters. A smoothed first derivative algorithm is used for peak tracking inside the detected events. To evaluate the proposed pile-up recovery algorithm theoretically and experimentally, it is applied on both simulated input signals generated with different time displacements between the piled-up events, and experimental preamplifier radiation signals. The obtained results prove that the proposed algorithm achieves better utilization of power and can be used for high count rate (high activity elements) spectroscopy systems.
- Application of 252Cf neutron source for precise nuclear data experiments. [Journal Article]
- ARAppl Radiat Isot 2019 Jun 08; 151:187-195
- Purpose of this paper is to provide extensive information helpful for anyone performing any experiment involving 252Cf neutron source and aiming for high precision experiments. The paper summarizes b…
Purpose of this paper is to provide extensive information helpful for anyone performing any experiment involving 252Cf neutron source and aiming for high precision experiments. The paper summarizes basic characteristics and fields of study using 252Cf neutron source. We show the basic characteristics of our source, precise geometry in MCNP6, isotopic content, distribution of the source in the encapsulation and possible use of encapsulation for 27Al(n,2n)26Al reaction estimation and the way of handling of the 252Cf neutron source in our laboratory. Furthermore, we prove that our source is volumetric, i.e. non-point and can be considered as an isotropic in our experimental settings. Influence of the palladium matrix density on the reaction rates is also investigated. Concerning nuclear data, we are measuring fast neutron leakage spectra in various benchmark sets including spheres of different materials. Our work extends benchmark sets to possible use of cubes, in our case graphite cube of side 30 cm. The neutron spectra are measured by stilbene scintilation detector in the energy range of 1-10 MeV in the steps of 100 keV in the distance of 100 cm from the centre of the cube. There is no significant difference between measurements performed using cube or sphere except lower cost for the cube production. The agreement between calculation using ENDF/B-VII.1 library and experimental data is not satisfactory especially in the regions around 3.5 MeV and 8 MeV. The agreement within 4% of calculation to experiment ratio for neutron leakage fluxes of pure 252Cf source validates our MCNP model for studying reaction rates and leakage fluxes in the region above 1 MeV.
- Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated. [Journal Article]
- AAtherosclerosis 2019 May 30; 287:38-45
- CONCLUSIONS: Serum cFAS is higher in patients with diabetes and CAS, appears to originate from the liver, and is LDL cholesterol associated. We postulate that LDL may be serving as a carrier for cFAS that contributes to atheroprogression in carotid arteries of patients with diabetes.
- Effect of residential exposure to green space on maternal blood glucose levels, impaired glucose tolerance, and gestational diabetes mellitus. [Journal Article]
- EREnviron Res 2019 Jun 06; 176:108526
- CONCLUSIONS: Living with higher levels of green space was significantly associated with decreased maternal glucose levels and attenuated risks of incident maternal IGT and GDM. Our findings provide evidence linking green space to better maternal glucose outcomes. More studies are needed to further explore the maternal and child health benefits related to our findings.
- Gut microbiota partially mediates the effects of fine particulate matter on type 2 diabetes: Evidence from a population-based epidemiological study. [Journal Article]
- EIEnviron Int 2019 Jun 12; 130:104882
- CONCLUSIONS: Long-term exposure to PM may increase the risk of diabetes, and alterations in the gut microbiota partially explained these associations.
- Factors affecting longer stay and higher costs during elective open repair for abdominal aortic aneurysm: a case control study. [Journal Article]
- AVAnn Vasc Surg 2019 Jun 12
- CONCLUSIONS: Regardless of the patients' comorbidities or aneurysm morphology, avoidance of transfusion and RTOR, combined with early ambulation and enteral feeding in the postoperative care can reduce the length of stay and total hospitalization costs associated with open surgery for AAA.
- Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: A randomized crossover study. [Journal Article]
- NNutrition 2019 Apr 25; 65:191-201
- There is no convincing evidence that krill oil (KO) consumption results in a higher incorporation of long chain ω-3 polyunsaturated fatty acids into blood lipid fractions than fish oil (FO). This stu…
There is no convincing evidence that krill oil (KO) consumption results in a higher incorporation of long chain ω-3 polyunsaturated fatty acids into blood lipid fractions than fish oil (FO). This study examined the postprandial plasma lipidomic responses to KO supplementation compared with FO supplementation in healthy women.
- Proteomic insights into short neurotoxin-driven, highly neurotoxic venom of Philippine cobra (Naja philippinensis) and toxicity correlation of cobra envenomation in Asia. [Journal Article]
- JPJ Proteomics 2019 Jun 12; :103418
- The Philippine cobra, Naja philippinensis, is a WHO Category 1 venomous snake of medical importance responsible for fatal envenomation in the northern Philippines. To elucidate the venom proteome and…
The Philippine cobra, Naja philippinensis, is a WHO Category 1 venomous snake of medical importance responsible for fatal envenomation in the northern Philippines. To elucidate the venom proteome and pathophysiology of envenomation, N. philippinensis venom proteins were decomplexed with reverse-phase high-performance liquid chromatography, and protein fractions were subsequently digested with trypsin, followed by nano-liquid chromatography-tandem mass spectrometry analysis and data mining. Three-finger toxins (3FTX, 66.63% of total venom proteins) and phospholipases A2 (PLA2, 22.88%) constitute the main bulk of venom proteome. Other proteins are present at low abundances (<4% each); these include metalloproteinase, serine protease, cobra venom factor, cysteine-rich secretory protein, vespryn, phosphodiesterase, 5' nucleotidase and nerve growth factor. In the three-finger toxin family, the alpha-neurotoxins comprise solely short neurotoxins (SNTX, 44.55%), supporting that SNTX is the principal toxin responsible for neuromuscular paralysis and lethality reported in clinical envenomation. Cytotoxins (CTX) are the second most abundant 3FTX proteins in the venom (21.31%). The presence of CTX correlates with the venom cytotoxic effect, which is more prominent in murine cells than in human cells. From the practical standpoint, SNTX-driven neuromuscular paralysis is significant in N. philippinensis envenomation. Antivenom production and treatment should be tailored accordingly to ensure effective neutralization of SNTX. BIOLOGICAL SIGNIFICANCE: The venom proteome of Naja philippinensis, the Philippine cobra, is unravelled for the first time. Approximately half the protein bulk of the venom is made up of short neurotoxins (44.5% of total venom proteins). As the only alpha-neurotoxins present in the venom, short neurotoxins are the causative toxins of the post-synaptic blockade and fast-onset neuromuscular paralysis in N. philippinensis envenomation. A substantial amount of cytotoxins (21.31%) was also detected in N. philippinensis venom, supporting that the venom is cytotoxic although the effect is much weaker in human cells compared to murine cells. The finding is consistent with the low incidence of local tissue necrosis in N. philippinensis envenomation, although this does not negate the need for monitoring and care of bite wound in the patients.
- Influence of moderate beer consumption on human gut microbiota and its impact on fasting glucose and β-cell function. [Journal Article]
- AAlcohol 2019 Jun 12
- Beer is a beverage consumed worldwide for thousands of years due to social, religious, and cultural reasons, it contains polyphenolic compounds as well as phenolic acids with a potential positive eff…
Beer is a beverage consumed worldwide for thousands of years due to social, religious, and cultural reasons, it contains polyphenolic compounds as well as phenolic acids with a potential positive effect in human health. This study aimed to explore the impact of moderate beer consumption in human health and gut microbiota function. 355 mL of non-alcoholic beer (NAB) or alcoholic beer (AB) were consumed daily by the participants for 30 days in each study. Anthropometric measures, blood samples for biochemistry, and fecal samples for microbiota analysis were collected on day 1 and 30. Microbial diversity was characterized by high throughput sequencing of 16S rDNA libraries, and data were analyzed using QIIME pipeline. We found, NAB and AB, have effect on the composition of the gut microbiota favoring the proliferation of Bacteroidetes with respect to Firmicutes. No increase in weight, waist, and hip parameters was observed, and the liver and lipid profile values were not modified only for NAB. In addition, the consumption of NAB induced a decrease in fasting blood serum glucose and an increase in functional β cells, while, on the other hand, there was an increase in blood serum glucose and decreased in functional β cells with the consumption of AB. In general, beer consumption neither change anthropometric values, nor affected liver function and although the glucose values decreased with NAB or increased with AB, they remained within normal range. Our conclusion is that moderate consumption of NAB has a positive effect on human health by supplementation of biological active polyphenol and phenolic acids, and by enrichment of the gut microbiota diversity with beneficial bacteria; while the presence of alcohol in AB interferes with this effect in our study. More work should be made on this topic before more general conclusions are drawn.
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- The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis. [Journal Article]
- LSLife Sci 2019 Jun 12; :116566
- CONCLUSIONS: These data suggest that the neuroprotective effects of liraglutide on diabetes-induced cognitive impairments are associated with the improvements of hippocampal synapses and inhibition of neuronal apoptosis.