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3,472 results
  • Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients. [Journal Article]
    J Immunother Cancer 2019; 7(1):293Ihle CL, Provera MD, … Owens P
  • The most common metastatic lesions of prostate cancer are in bone and can be classified into three distinct pathology subtypes: lytic, blastic, and an indeterminate mixture of both. We investigated a cohort of decalcified formalin-fixed and paraffin-embedded (FFPE) patient specimens from the bone that contained metastatic prostate cancer with lytic or blastic features. These tissue sections were …
  • Co-occurring genetic alterations and primary EGFR T790M mutations detected by NGS in pre-TKI-treated NSCLCs. [Journal Article]
    J Cancer Res Clin Oncol 2019Tang Y, Che N, … Lin D
  • CONCLUSIONS: NSCLC patients represented genetically heterogeneous subgroup with a high frequency of co-occurring mutations in cancer-associated pathways. This diverse mutational profile may have key clinical and research implications for understanding the variability of treatment outcome in pre-TKI-treated NSCLC population. The differences in the MAF of EGFR T790M may determine different responses to TKI therapy in patients harboring dual mutations.
  • PCR Amplifiable DNA from Breast Disease FFPE Section for Mutational Analysis. [Journal Article]
    J Biomol Tech 2019Panchal NK, Bhale A, … Beevi SS
  • Formalin-fixed paraffin-embedded (FFPE) tissue specimens have been a staple of research, providing precious resources for molecular and genomic studies. However, the biggest challenge is the extraction of high-quality DNA from FFPE tissues, given that the integrity of DNA is critically affected by formalin fixation. Formaldehyde induces crosslinks in DNA that renders single or double-stranded DNA…
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