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66 results
  • Primary aldosteronism associated with a germline variant in CACNA1H. [Journal Article]
    BMJ Case Rep 2019; 12(5)Wulczyn K, Perez-Reyes E, … Park M
  • The CACNA1H gene encodes the pore-forming α1 subunit of the T-type voltage-dependent calcium channel CaV3.2, expressed abundantly in the adrenal cortex. Mutations in CACNA1H are associated with various forms of primary aldosteronism (PA), including familial hyperaldosteronism type 4 (FH4). We describe a patient with refractory hypokalaemia and elevated aldosterone secretion independent of renin a…
  • StatPearls: Biochemistry, Tetrahydrofolate [BOOK]
    StatPearls Publishing: Treasure Island (FL) Tjong Elysia E A.T. Still University School of Medicine Mohiuddin Shamim S. SS Imam Abdulrahman Bin Faisal University, Dammam BOOK
  • Tetrahydrofolate or tetrahydrofolic acid is a folic acid derivative that serves as a coenzyme for metabolic reactions involving amino acids and nucleic acids. The term "folate" denoted a water-soluble B-complex vitamin that functions in the transfer process of single-carbon groups at different stages of oxidation and essential for biosynthesis of certain amino acid, purine bases  and thymine whic…
  • Low-dose methotrexate enhances cycling of highly anaplastic cancer cells. [Journal Article]
    Cell Cycle 2017; 16(3):280-285Cipolleschi MG, Marzi I, … Dello Sbarba P
  • We previously showed that cellular RedOx state governs the G1-S transition of AH130 hepatoma, a tumor spontaneously reprogrammed to the embryonic stem cell stage. This transition is impaired when the mithocondrial electron transport system is blocked by specific inhibitors (antimycin A) or the respiratory chain is saturated by adding to the cells high concentrations of pyruvate. The antimycin A o…
  • Examination of the Feynman-Hibbs Approach in the Study of NeN-Coronene Clusters at Low Temperatures. [Journal Article]
    J Phys Chem A 2016; 120(27):5370-9Rodríguez-Cantano R, Pérez de Tudela R, … Bretón J
  • Feynman-Hibbs (FH) effective potentials constitute an appealing approach for investigations of many-body systems at thermal equilibrium since they allow us to easily include quantum corrections within standard classical simulations. In this work we apply the FH formulation to the study of NeN-coronene clusters (N = 1-4, 14) in the 2-14 K temperature range. Quadratic (FH2) and quartic (FH4) contri…
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