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13,563 results
  • Sex differences in the pharmacology of itch therapies-a narrative review. [Review]
  • COCurr Opin Pharmacol 2019 Jul 09; 46:122-142
  • Schmid Y, Navarini A, … Mueller SM
  • CONCLUSIONS: Our review supports previous reports that sex is of importance in the pharmacokinetics and /-dynamics of several drugs used to treat itch although those drugs were mostly evaluated for non-itch indications. However, the results are limited by methodological limitations evident in most studies such as underrepresentation of women in clinical trials. This emphasises the need to study the impact of sex (and gender) in future itch trials to yield better outcomes and prevent ADRs in both sexes.
  • Mesembrine: The archetypal psycho-active Sceletium alkaloid. [Review]
  • PPhytochemistry 2019 Jul 09; 166:112061
  • Makolo F, Viljoen A, Veale CGL
  • (-)-Mesembrine is a chiral alkaloid that features an aryloctahydroindole skeleton and is most commonly found in species of the succulent genus Sceletium. Several Sceletium species are used by various…
  • Antidepressant Withdrawal and Rebound Phenomena. [Journal Article]
  • DADtsch Arztebl Int 2019 May 17; 116(20):355-361
  • Henssler J, Heinz A, … Bschor T
  • CONCLUSIONS: A robust evidence base now indicates that there can be acute with- drawal phenomena when antidepressants are discontinued. Putative rebound phenomena have not been adequately studied to date. It is recommended that antidepressants should be tapered off over a period of more than four weeks.
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