- Prevalence of hypertension among office workers in a multi-national company in the Niger-Delta with the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. [Journal Article]
- PMPrev Med Rep 2019; 15:100899
- The 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guidelines propose a new classification of blood pressure (BP). The objective was to compare the prevalence o…
The 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guidelines propose a new classification of blood pressure (BP). The objective was to compare the prevalence of hypertension among staff of a multinational oil/gas company in Niger-Delta, Nigeria using the 2017 ACC/AHA guidelines and the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) guidelines. Cross-sectional analysis of 235 individuals who presented for their annual medical review between March 2017 and February 2018 was done. Demographic, medical and family history data were obtained with a questionnaire. Blood pressure was measured using the recommended procedure. Fasting blood samples were analysed for blood glucose and lipids. Ten-year cardiovascular risk was estimated with the 2008 modified Framingham risk score (FRS). The prevalence of hypertension using the JNC7 and the 2017 ACC/AHA guidelines was 25.9% and 53.9% respectively. With the former, family history of hypertension and increased BMI were independently significantly associated with hypertension. With the latter, male gender, family history of hypertension, BMI and physical inactivity were significant predictors of hypertension. 184 (78.3%) were categorised as low CVD risk, 38 (16.2%) intermediate risk and 13 (5.5%) high risk for CVD. The 2017 ACC/AHA guidelines doubled the prevalence of hypertension from 25.9% to 53.9%. Adoption of this guideline will necessitate careful consideration of the consequences of labeling individuals as hypertensive as well as an increment of the health care budget provided by companies for its staff to meet the increased burden of hypertension.
- Schneider's first-rank symptoms as predictors of remission in antipsychotic-naive first-episode psychosis. [Journal Article]
- BJBraz J Psychiatry 2019 May 30
- CONCLUSIONS: Specific FRS may predict remission after treatment in FEP patients. This finding could give new importance to Kurt Schneider's classic work by contributing to future updates of diagnostic protocols and improving estimation of prognosis.
- The value of carotid ultrasound in cardiovascular risk stratification in patients with psoriatic disease. [Journal Article]
- ARArthritis Rheumatol 2019 Jun 05
- CONCLUSIONS: The burden of carotid atherosclerosis is associated with an increased risk of developing future CVE. Combining vascular imaging data with information on traditional cardiovascular risk factors could improve the accuracy of cardiovascular risk stratification in patients with PsD. This article is protected by copyright. All rights reserved.
- Iron Consumption Is Not Consistently Associated with Fecundability among North American and Danish Pregnancy Planners. [Journal Article]
- JNJ Nutr 2019 Jun 01
- CONCLUSIONS: Overall, dietary intake of iron was not consistently associated with fecundability, although there was some evidence for a positive association among women with risk factors for iron deficiency. We also found a small positive association between supplemental iron intake and fecundability among North American, but not Danish, pregnancy planners.
- Occurrence of two novel triazine-based flame retardants in an E-waste recycling area in South China: Implication for human exposure. [Journal Article]
- STSci Total Environ 2019 May 20; 683:249-257
- The recent increase in the use of alternative flame retardants (FRs) in consumer products has led to emerging contaminants in the environment. Identification of novel FRs is urgently needed because t…
The recent increase in the use of alternative flame retardants (FRs) in consumer products has led to emerging contaminants in the environment. Identification of novel FRs is urgently needed because the potential threat posed by these chemicals has provoked considerable attention, but the details of the threat are not yet widely understood. In this study, two novel triazine-based FRs, tris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO) and 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine (TTBP-TAZ), were identified in dust samples from an e-waste recycling area in China. Two legacy FRs, namely, tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCDD), were also analyzed for comparison. The mean level of TDBP-TAZTO in the e-waste dust samples was found to be much higher (2060 ng g-1) than that of HBCDD (526 ng g-1), while the mean level of TTBP-TAZ in residential dust samples was moderately higher (119 ng g-1) than that of HBCDD (35.7 ng g-1). A comparison of the TDBP-TAZTO and TTBP-TAZ concentrations with those of other alternative and legacy FRs indicated that TDBP-TAZTO is a major FR that is currently used in China. The estimated daily intake of TDBP-TAZTO via dust ingestion for occupational workers was much higher than that of HBCDD and was also much higher than for local adults and children. Exposure to TDBP-TAZTO poses a potentially high risk to the health of the local population, especially for the occupational workers, when the multicomponent chemical 'cocktail' effects are taken into account. More investigations on the environmental behaviors and risk factors of TDBP-TAZTO and TTBP-TAZ in various environmental matrices, as well as their toxicological effects, should be performed in the future.
- Exposure of Canadian electronic waste dismantlers to flame retardants. [Journal Article]
- EIEnviron Int 2019; 129:95-104
- Exposure of e-waste workers to eight halogenated and five organophosphate ester flame retardant chemicals (FRs) was studied at a Canadian e-waste dismantling facility. FR concentrations were measured…
Exposure of e-waste workers to eight halogenated and five organophosphate ester flame retardant chemicals (FRs) was studied at a Canadian e-waste dismantling facility. FR concentrations were measured in air and dust samples collected at a central location and at four work benches over five-24 hour periods spanning two weeks. The highest concentrations in air from workbenches were of BDE-209 (median 156 ng m-3), followed by Tris(2-chloroethyl) phosphate (TCEP, median 59 ng m-3). Dust concentrations at the workbenches were higher than those measured at the central location, consistent with the release of contaminated dust during dismantling. Dust concentrations from the workbenches were also dominated by BDE-209 (median 96,300 ng g-1), followed by Triphenyl phosphate (TPhP, median 47,000 ng g-1). Most FRs were in coarse particles 5.6-18 μm diameter and ~30% were in respirable particles (<~3 μm). Exposure estimates indicated that dust ingestion accounted for 63% of total FR exposure; inhalation and dermal absorption contributed 35 and 2%, respectively. Some air and dust concentrations as well as some estimated exposures in this formal facility in a high-income country exceeded those from informal e-waste facilities located in low and middle income countries. Although there is demonstrated toxicity of some FRs, FR exposure in the e-waste industry has received minimal attention and occupational limits do not exist for most FRs.
- Validation of original and alternative fistula risk scores in postoperative pancreatic fistula. [Journal Article]
- JHJ Hepatobiliary Pancreat Sci 2019 May 24
- CONCLUSIONS: Both o-FRS and a-FRS might reflect CR-POPF incidence, but some risk factors had no or low statistical significance. Further research is needed to revise the FRS. This article is protected by copyright. All rights reserved.
- Bioabsorbable steroid-eluting sinus stents for patients with refractory frontal diseases undergoing a revision Draf 3 procedure: a case series. [Journal Article]
- AOActa Otolaryngol 2019; 139(7):636-642
- Background: Bioabsorbable steroid-eluting sinus stents are safe and effective in maintaining the patency of the frontal sinus ostium. Aims/objectives: To assess the efficacy of steroid-eluting sinus…
Background: Bioabsorbable steroid-eluting sinus stents are safe and effective in maintaining the patency of the frontal sinus ostium. Aims/objectives: To assess the efficacy of steroid-eluting sinus stents in improving postoperative outcomes following revision and re-revision Draf 3 procedures in patients with frontal diseases. Material and methods: Patients with recalcitrant chronic frontal rhinosinusitis (FRS) and mucocele who underwent revision and re-revision Draf 3 procedures from 2015 to 2017 were included. Preoperative disease parameters, demographics, and endoscopic and radiographic images were recorded. Results: Seven patients undergoing the Draf 3 procedure for recalcitrant chronic FRS (43%) and mucocele after complete resection of benign tumours in the frontal sinus (57%) were followed up for a mean of 16.5 months. At the end of follow-up, seven (100%) patients were asymptomatic and all patients (100%) had patent neo-ostia. Conclusions and significance: The use of bioabsorbable steroid-eluting sinus stents had no unanticipated consequences, and the drainage pathways of the frontal neo-ostium remained patent. Steroid-eluting sinus stents may decrease recurrence rates in revision cases where patients have extensive scarring or neo-osteogenesis of the operative field from prior Draf 2 or 3 procedures. Further follow-up of the current cases and studies with larger cohorts are needed.
- Physical activity, sedentary behavior, and long-term cardiovascular risk in individuals with rheumatoid arthritis. [Journal Article]
- PSPhys Sportsmed 2019 Jun 05; :1-8
- CONCLUSIONS: Strategies for decreasing SB and increasing PA should be explored with individuals with RA in order to decrease long-term CVD risk.
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- Ganoderma lucidum polysaccharide reduces melanogenesis by inhibiting the paracrine effects of keratinocytes and fibroblasts via IL-6/STAT3/FGF2 pathway. [Journal Article]
- JCJ Cell Physiol 2019 May 21
- Our previous study found that Ganoderma lucidum polysaccharide (GLP), bioactive ingredients from Ganoderma lucidum, protected fibroblasts from photoaging. However, whether GLP can affect melanogenesi…
Our previous study found that Ganoderma lucidum polysaccharide (GLP), bioactive ingredients from Ganoderma lucidum, protected fibroblasts from photoaging. However, whether GLP can affect melanogenesis in melanocytes through regulating paracrine mediators that secreted by keratinocytes and fibroblasts is unclear. We aimed to investigate the efficacy and mechanisms of action of GLP in melanogenesis by regulating paracrine effects of keratinocytes and fibroblasts. The effect of GLP on cell viability affected by GLP was measured by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. After an immortal keratinocyte line (HaCaT) and primary fibroblasts (FB) were treated with GLP, the supernatants of HaCaT and FB cells were collected and cocultured with an immortalized melanocyte line (PIG1). The expression levels of melanogenesis-associated genes in PIG1 cells were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis. Furthermore, FRS-2, ERK, JNK, and p38 phosphorylation levels were measured. Then, major melanogenic paracrine mediators in HaCaT and FB cells treated with GLP were evaluated by qRT-PCR and enzyme-linked immunosorbent assay (ELISA). In addition, the expression of IL-6 and STAT3 was examined in HaCaT and FB cells. GLP was not cytotoxic to HaCaT and FB cells. The supernatants of GLP-treated HaCaT and FB cells downregulated the expression levels of MITF, TYR, TYRP1, TYRP2, RAB27A, and FSCN1 genes and inhibited the phosphorylation of FRS-2, ERK, JNK, and p38 in PIG1 cells. GLP also decreased FGF2 secretion in HaCaT and FB cells. Moreover, GLP reduced IL-6 expression and STAT3 phosphorylation in HaCaT and FB cells. GLP reduced melanogenesis in melanocytes by inhibiting the paracrine effects of keratinocytes and fibroblasts via IL-6/STAT3/FGF2 pathway.