- Retrospective study of nivolumab for patients with recurrent high grade gliomas. [Journal Article]
- JNJ Neurooncol 2018 May 19
- CONCLUSIONS: Treatment with nivolumab therapy was associated with a manageable safety profile. In a subset of patients, there was disease stabilization in heavily pre-treated recurrent HGG.
- Quality of life, symptoms and care needs in patients with persistent or recurrent platinum-resistant ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study. [Journal Article]
- GOGynecol Oncol 2018 May 17
- CONCLUSIONS: In patients nearing the end of life, there are significant associations between disease and treatment related symptoms and unmet patient needs, which do not change substantially over time. Careful exploration of specific end-of-life care needs can improve patient-centered care and QOL.
- Treatment of Chronic Obstructive Pulmonary Disease in the Primary Care Setting: How Can We Achieve More for Our Patients? [Journal Article]
- AJAm J Med 2018 May 17
- Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive disease that is both under-diagnosed and under-treated, affecting up to 1 in 10 older adults. Common symptoms, including...
Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive disease that is both under-diagnosed and under-treated, affecting up to 1 in 10 older adults. Common symptoms, including dyspnea, productive cough, chest tightness, and fatigue, can reduce quality of life, ability to participate in all types of activities, and overall health status in patients. Minimizing the impact of symptoms on patients' quality of life should be a key goal for physicians and modest changes in current practice could make improvements in patients' lives. Here we review COPD, its impact on patients, and how to improve symptom management.
- An Approach for Brain-Controlled Prostheses Based on Scene Graph Steady-State Visual Evoked Potentials. [Journal Article]
- BRBrain Res 2018 May 16
- Brain control technology can restore communication between the brain and a prosthesis, and choosing a Brain-Computer Interface (BCI) paradigm to evoke electroencephalogram (EEG) signals is an essenti...
Brain control technology can restore communication between the brain and a prosthesis, and choosing a Brain-Computer Interface (BCI) paradigm to evoke electroencephalogram (EEG) signals is an essential step for developing this technology. In this paper, the Scene Graph paradigm used for controlling prostheses was proposed; this paradigm is based on Steady-State Visual Evoked Potentials (SSVEPs) regarding the Scene Graph of a subject's intention. A mathematic model was built to predict SSVEPs evoked by the proposed paradigm and a sinusoidal stimulation method was used to present the Scene Graph stimulus to elicit SSVEPs from subjects. Then, a 2-degree of freedom (2-DOF) brain-controlled prosthesis system was constructed to validate the performance of the Scene Graph-SSVEP (SG-SSVEP)-based BCI. The classification of SG-SSVEPs was detected via the Canonical Correlation Analysis (CCA) approach. To assess the efficiency of proposed BCI system, the performances of traditional SSVEP-BCI system were compared. Experimental results from six subjects suggested that the proposed system effectively enhanced the SSVEP responses, decreased the degradation of SSVEP strength and reduced the visual fatigue in comparison with the traditional SSVEP-BCI system. The average signal to noise ratio (SNR) of SG-SSVEP was 6.31±2.64 dB, versus 3.38±0.78 dB of traditional-SSVEP. In addition, the proposed system achieved good performances in prosthesis control. The average accuracy was 94.58%±7.05%, and the corresponding high information transfer rate (IRT) was 19.55±3.07 bit/min. The experimental results revealed that the SG-SSVEP based BCI system achieves the good performance and improved the stability relative to the conventional approach.
- An Early View of Real-World Patient Response to Sacubitril/Valsartan: A Retrospective Study of Patients with Heart Failure with Reduced Ejection Fraction. [Journal Article]
- ATAdv Ther 2018 May 17
- CONCLUSIONS: The findings of this real-world investigation suggest sacubitril/valsartan is associated with symptom improvements and a reduction in hospitalizations within 4 months of treatment for patients with HF and reduced ejection fraction.
- Fatigue-related risk management in the emergency department: a focus-group study. [Journal Article]
- IEIntern Emerg Med 2018 May 18
- Fatigue has major implications on both patient safety and healthcare practitioner's well-being. Traditionally, two approaches can be used to reduce fatigue-related risk: reducing the likelihood of a ...
Fatigue has major implications on both patient safety and healthcare practitioner's well-being. Traditionally, two approaches can be used to reduce fatigue-related risk: reducing the likelihood of a fatigued operator working (i.e. fatigue reduction), or reducing the likelihood that a fatigued operator will make an error (i.e. fatigue proofing). Recent progress mainly focussed on fatigue reduction strategies such as reducing work hours. Yet it has to be recognized that such approach has not wholly overcome the experience of fatigue. Our purpose is to investigate individual proofing and reduction strategies used by emergency physicians to manage fatigue-related risk. 25 emergency physicians were recruited for the study. Four focus groups were formed which consisted of an average of six individuals. Qualitative data were collected using a semi-structured discussion guide unfolding in two parts. First, the participants were asked to describe how on-the-job fatigue affected their efficiency at work. A mind map was progressively drawn based upon the participants' perceived effects of fatigue. Second, participants were asked to describe any strategies they personally used to cope with these effects. We used inductive qualitative content analysis to reveal content themes for both fatigue effects and strategies. Emergency physicians reported 28 fatigue effects, 12 reduction strategies and 21 proofing strategies. Content analysis yielded a further classification of proofing strategies into self-regulation, task re-allocation and error monitoring strategies. There is significant potential for the development of more formal processes based on physicians' informal strategies.
- Seroprevalence of Brucellosis in Butchers, Veterinarians and Slaughterhouse Workers in Hamadan, Western Iran. [Journal Article]
- JRJ Res Health Sci 2018 Feb 10; 18(1):e00406
- CONCLUSIONS: High prevalence of brucellosis in these occupational groups and symptomatic disease in significant numbers of them, so periodic clinical examinations in these groups seems to be essential for brucellosis surveillance system.
- Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe. [Journal Article]
- JAJ Am Heart Assoc 2018 May 18; 7(11)
- CONCLUSIONS: A higher symptom burden, in particular palpitations, predicted interventions to restore sinus rhythm. The score itself had limited predictive value, but its individual components were related to different and specific clinical events, and may thus be helpful to target patient management.
- Effects of Reflexology and Progressive Muscle Relaxation on Pain, Fatigue, and Quality of Life during Chemotherapy in Gynecologic Cancer Patients. [Journal Article]
- PMPain Manag Nurs 2018 May 15
- Our aim was to investigate the effect of reflexology and progressive muscle relaxation (PMR) exercises on pain, fatigue, and quality of life (QoL) of gynecologic cancer patients during chemotherapy. ...
Our aim was to investigate the effect of reflexology and progressive muscle relaxation (PMR) exercises on pain, fatigue, and quality of life (QoL) of gynecologic cancer patients during chemotherapy. Eighty participants were randomly assigned to one of four groups: reflexology, progressive muscle relaxation (PMR) exercises, both (reflexology + PMR), or a control group. Data were collected with a general data collection form, Brief Pain and Fatigue inventories, and Multidimensional Quality-of-Life Scale-Cancer. In reflexology and reflexology + PMR groups, a significant decrease in pain severity and fatigue and an increase in QoL were found (p < .05). In the PMR alone group, pain severity and fatigue decreased significantly (p < .05), but there was no significant change identified in QOL (p > .05). Reflexology and PMR exercises given to gynecologic cancer patients during chemotherapy were found to decrease pain and fatigue and increase QoL.
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- Comparison of efficacy of colonoscopy between the morning and afternoon: A systematic review and meta-analysis. [Review]
- DLDig Liver Dis 2018 Apr 09
- CONCLUSIONS: Colonoscopy quality, as indicated by the ADR and CIR, is not affected by the time of day for procedures performed in block shifts. However, endoscopists' working full-day blocks and inferior bowel preparation are associated with a significant decrease in ADR and CIR in the afternoon.