- Integrated Rehabilitation for Breast Cancer Survivors. [Journal Article]
- AJAm J Phys Med Rehabil 2018 Aug 16
- The physical and psychological side effects of breast cancer therapies can have substantial impact on survivors' physical and social functioning. Roughly half of the more than 3 million Americans ali...
The physical and psychological side effects of breast cancer therapies can have substantial impact on survivors' physical and social functioning. Roughly half of the more than 3 million Americans alive with a history of breast cancer report adverse, function-degrading sequelae related to their oncologic treatments. Care delivery models for the timely delivery of rehabilitation services have been proposed yet limitedly vetted or implemented. These include the prospective surveillance model, procedure-linked referrals, survivorship care plans and risk stratification. Patients' capacity to engage in the rehabilitative process varies over the course of cancer therapy and into survivorship. Perioperative attention generally focuses on managing premorbid impairments and normalizing shoulder function. In contrast, during chemo- and radiation therapies, symptom control, constructive coping, and role preservation may become more salient. Risk-stratified, individualized screening and prevention activities for specific impairments have become increasingly feasible through predictive models and analytics. Impairments' severity deleterious impact can be mitigated, as has been established for lymphedema, shoulder dysfunction, chemotherapy-induced peripheral neuropathy, cognitive dysfunction, fatigue, and sexual side effects. Integrated rehabilitative programs, often initiated following the completion of cancer treatment, are available in some countries outside of the United States and may offer survivors vital vocation- and avocation-directed services.
- Long-term antibody persistence against hepatitis B in adolescents 14-15-years of age vaccinated with 4 doses of hexavalent DTPa-HBV-IPV/Hib vaccine in infancy. [Journal Article]
- HVHum Vaccin Immunother 2018 Aug 17
- We evaluated antibody persistence against hepatitis B virus (HBV) in adolescents previously vaccinated with a hexavalent diphtheria-tetanus-acellular pertussis-HBV-inactivated poliovirus-Haemophilus ...
We evaluated antibody persistence against hepatitis B virus (HBV) in adolescents previously vaccinated with a hexavalent diphtheria-tetanus-acellular pertussis-HBV-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine (DTPa-HBV-IPV/Hib), as part of the national newborn immunization program in Germany. We also assessed the anamnestic response to a challenge dose of a monovalent HBV vaccine. In this phase 4, open-label, non-randomized study (NCT02798952), 302 adolescents aged 14-15 years, primed in their first 2 years of life with 4 DTPa-HBV-IPV/Hib doses, received one challenge dose of monovalent HBV vaccine. Blood samples were taken before and one month post-vaccination and used to determine antibody levels against hepatitis B surface antigen (HBs). Reactogenicity and safety were also assessed post-challenge dose. Pre-challenge dose, 53.7% of 268 participants included in the according-to-protocol cohort for immunogenicity had anti-HBs antibody concentrations ≥10 mIU/mL (seroprotection cut-off) and 16.8% had anti-HBs antibody concentrations ≥100 mIU/mL. One month post-challenge dose, 93.3% of adolescents had anti-HBs antibody concentrations ≥10 mIU/mL and 87.3% had antibody concentrations ≥100 mIU/mL. An anamnestic response was mounted in 92.5% of adolescents. Injection site pain (in 33.6% of participants) and fatigue (30.2%) were the most frequently reported solicited local and general symptoms, respectively. Six of the 55 unsolicited adverse events reported were considered vaccination-related. Two vaccination-unrelated serious adverse events were reported during the study. Long-term antibody persistence against hepatitis B was observed in 14-15 years old adolescents previously primed in infancy with DTPa-HBV-IPV/Hib. A challenge dose of monovalent HBV vaccine induced strong anamnestic response, with no safety concerns.
- A Novel Infant Chest Compression Assist Device Using a Palm Rather Than Fingers: A Randomized Crossover Trial. [Journal Article]
- PEPrehosp Emerg Care 2018 Aug 17; :1-9
- CONCLUSIONS: Compression with palm pressers resulted in greater compression depth without increasing hands-off time and reduced rescuer fatigue compared with compression with the TFT in simulated infant CPR with manikins.
- The safety of bortezomib for the treatment of multiple myeloma. [Journal Article]
- EOExpert Opin Drug Saf 2018 Aug 17
- There is now 16 years' worth of established results of various trials demonstrating the bortezomib efficiency in the treatment of multiple myeloma. Over this time, the introduction of bortezomib has ...
There is now 16 years' worth of established results of various trials demonstrating the bortezomib efficiency in the treatment of multiple myeloma. Over this time, the introduction of bortezomib has been a major break through in the treatment of multiple myeloma. Bortezomib can be administered in the outpatient setting with manageable toxicities. Areas covered: A literature search was carried out using PubMed and Google Scholar. This review gives an overview of the critical role of the bortezomib in multiple myeloma and provides a comprehensive summary of key clinical benefit and safety data with the bortezomib. Initial toxicity profile has improved dramatically with introduction of subcutaneous administration and also, implementation of guidelines for early recognition and treatment. Triplet and quadruplets of bortezomib with agents possessing similar toxicities constitute a challenge. Expert opinion: Bortezomib is an important part of current anti-myeloma therapy with a good clinical efficacy and manageable side effects. Although gastrointestinal disturbances and fatigue are the most common adverse effects, peripheral neuropathy and thrombocytopenia are the key dose-limiting toxicities of bortezomib based combination regimens. Since these combinations are more effective, with faster disappearance of disease related symptoms and anti-inflammatory effects of bortezomib toxicities were not found to be augmented.
- Symptoms, Mobility and Function, and Quality of Life in Adults With Acute Leukemia During Initial Hospitalization. [Journal Article]
- ONOncol Nurs Forum 2018 Sep 01; 45(5):653-664
- CONCLUSIONS: The significant decrease in anxiety and fatigue during hospitalization may be attributable to understanding of the disease process, familiarity with the staff, and ability to communicate concerns.
- Illness beliefs of adolescents with CFS and their parents: the perceived causes of illness and beliefs about recovery. [Journal Article]
- IJInt J Adolesc Med Health 2018 Aug 17
- Life cycle analysis of electrically actuated SMA spring using Talbot interferometry. [Journal Article]
- AOAppl Opt 2018 Jul 10; 57(20):5779-5783
- Electrically actuated shape memory alloys (SMAs) find widespread applications in engineering and science. Such materials are known to retain/remember their state. In the stressed/deformed state, when...
Electrically actuated shape memory alloys (SMAs) find widespread applications in engineering and science. Such materials are known to retain/remember their state. In the stressed/deformed state, when activated by the application of a suitable excitation mechanism, such as the use of heat or potential, they return to their original unstressed state. To test their reliability, it is a standard procedure to undertake a life cycle analysis. In this paper, the life cycle analysis of a SMA spring using the Talbot interferometric technique is reported. The life cycle of the SMA spring is analyzed in terms of the displacement drift, which sets in because of the functional fatigue generated due to its repeated use. Collimated light from a He-Ne laser transmitted through a beam splitter is converged through a focusing lens onto a plane mirror attached to the spring. Backreflected light from the mirror is incident on a set of two Ronchi gratings separated by the Talbot distance, forming a moiré pattern. The resulting interferograms are analyzed using a fringe rotation mechanism. The angle of orientation is a function of displacement drift. There is deterioration in the SMA property because of repeated cycles, and the spring loses its ability to return to its original unstretched position. The values of the displacement drift generated after 1, 1000, 2000, 3000, 4000, and 5000 such cycles as measured using a Talbot interferometer are 0, 0.875, 1.275, 1.459, 1.720, and 1.859 mm, respectively. It is observed that the SMA effect deteriorates as the number of stretching/contraction cycles increases. The uncertainty analysis is also reported. The expanded uncertainty was determined to be 201.61 μm.
- Induction thermography of steel coupons with cracks. [Journal Article]
- AOAppl Opt 2018 Jun 20; 57(18):D40-D48
- The induction thermography technique was assessed experimentally and numerically on notched steel coupons using two coil configurations: straight line and loop conditions. The coupons had different l...
The induction thermography technique was assessed experimentally and numerically on notched steel coupons using two coil configurations: straight line and loop conditions. The coupons had different lengths of fatigue crack varying from zero to 3 mm. The numerical predictions showed that the peak temperature was always located at the crack tip or the notch tip position. The loop coil resulted in higher temperatures than those of the straight line coil. Results showed that the numerical methods effectively supported the application assessment of this nondestructive evaluation (NDE) technique for the steel material, but crack geometry remains a challenge as the exact shape of a natural crack is typically unknown. It is shown that induction thermography can detect a crack as small as 1 mm in the notched steel coupons. Commentary on the application of the NDE technique with the numerical modeling support was provided.
- Clinical Benefits of Acupuncture for the Reduction of Hormone Therapy-Related Side Effects in Breast Cancer Patients: A Systematic Review. [Journal Article]
- ICIntegr Cancer Ther 2018; 17(3):602-618
- CONCLUSIONS: Acupuncture therapy appears to be potentially useful in relieving functional stiffness. However, further large-sample trials with evidence-based design are still needed to confirm these findings.
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- Visualization and Bibliometric Analysis of Research Trends on Human Fatigue Assessment. [Journal Article]
- JMJ Med Syst 2018 Aug 17; 42(10):179
- This study aims to analyze the scientific research progress on human fatigue assessment (HFA) by using a bibliometric method, which was conducted a systematic analyses of 28,028 scientific papers abo...
This study aims to analyze the scientific research progress on human fatigue assessment (HFA) by using a bibliometric method, which was conducted a systematic analyses of 28,028 scientific papers about HFA from the Web of Science database, and the results were discussed from the following perspectives: temporal distribution, geographical distribution, discipline distribution, and key words distribution. In addition, this analysis also provides the network of author co-citation and key words. The results are summarized as follows: 1) the number of papers about HFA increased rapidly since 1990s; 2) The United States is a high-yield, high-cited country with 36.70% of the world's total literatures, and whose average citation index on HFA research is 47.89 per paper; China is the developing country with the largest number of publications, but its total citations and average citations are backward, only with an average of 21 citations per article; 3) The assessment of human fatigue shows the development trend of multidisciplinary intersecting; 4) There is a relative lack of cooperation among the world's leading scholars; the Dutch Gijs Bleijenberg is the most published scholar in the world, who have 108 articles on HFA research; the American scholar David Cella has the most influential article, with an h-index of 36; the distribution of Chinese scholars is relatively scattered, and no one has written more than five articles; 5) All of countries in the world had the same research topics, "muscle fatigue" is an important part of the HFA; China needs to pay more attention to the fatigue assessment associated with cancer. The results of the analysis can be used to enhance our understanding of HFA research and support further research in this area.