- Epidemiology of Acute Febrile Illness in Latin America. [Review]
- CMClin Microbiol Infect 2018 May 16
- CONCLUSIONS: DENV is the febrile illness most frequently reported, reflecting its importance, while CHIKV and ZIKV present increasing trends since its emergence in the region. Studies with systematic and harmonized approach for detection of multiple pathogens are needed and would probably reveal a higher burden of neglected pathogens such as Rickettsia spp. and arenaviruses. The lack of point-of-care tests and harmonized approach limits the care provided by health professionals and the efficacy of surveillance for AFI in the region.
- [A Case of Renal Pelvic Cancer with Acquired Hemophilia and Leukemoid Reaction]. [Journal Article]
- HKHinyokika Kiyo 2018; 64(4):151-155
- A 71-year-old man was referred to us with a right renal mass that was discovered by computed tomography (CT) examination for acquired hemophilia and leukemoid reaction. He presented with persistent l...
A 71-year-old man was referred to us with a right renal mass that was discovered by computed tomography (CT) examination for acquired hemophilia and leukemoid reaction. He presented with persistent low-grade fever and purpura on the lower legs caused by acquired hemophilia. Contrastenhanced CT scan showed a right renal tumor 6.0×7.4 cm in diameterwith inhomogeneous enhancement. The result of his urine cytology was negative. After improvement of his coagulation by treatment with immunosuppressants and steroids, he underwent open nephrectomy. Histology of renal tissue revealed urothelial carcinoma (G3, pT4, N1). After surgery, his complete blood counts and coagulation improved without administration of immunosuppressants and steroids. Therefore, he was diagnosed with renal pelvic cancer with acquired hemophilia and leukemoid reaction.
- Diagnostic challenges in chikungunya infection: Report of an atypical presentation. [Journal Article]
- CCCan Commun Dis Rep 2015 Jan 08; 41(1):6-10
- Due in part to increasing global travel, chikungunya fever has emerged as a significant public health concern. With recent outbreaks in Caribbean nations and the first report of locally acquired infe...
Due in part to increasing global travel, chikungunya fever has emerged as a significant public health concern. With recent outbreaks in Caribbean nations and the first report of locally acquired infection in the United States, there is concern that we may see an increasing number of cases in Canada. As chikungunya fever shares many clinical similarities to other arthropod-borne illnesses such as dengue fever, clinical diagnosis is challenging. We report an atypical presentation of acute chikungunya fever in a man returning from travel to Haiti. Microbiologic diagnosis, treatment, prognosis, and public health implications will aid clinician preparedness for this emerging pathogen.
- Travel-acquired infections in Canada: CanTravNet 2011-2012. [Journal Article]
- CCCan Commun Dis Rep 2014 Sep 18; 40(16):313-325
- Important gaps remain in our knowledge of the infectious diseases people acquire while travelling and the impact of pathogens imported by Canadian travellers.
Important gaps remain in our knowledge of the infectious diseases people acquire while travelling and the impact of pathogens imported by Canadian travellers.
- Clinical and laboratory features of children with community-acquired pneumonia are associated with distinct radiographic presentations. [Journal Article]
- EJEur J Pediatr 2018 May 11
- CONCLUSIONS: Alveolar CAP, non-alveolar CAP, and clinical CAP are distinct entities differing not only by chest radiographic appearance but also in clinical and laboratory characteristics. Alveolar CAP has unique characteristics, which suggest association with bacterial etiology.
- Risk Factors for Severe Community-Acquired Pneumonia Among Children Hospitalized with CAP Younger Than 5 Years of Age. [Journal Article]
- PIPediatr Infect Dis J 2018 May 09
- CONCLUSIONS: Pediatric CAP hospitalizations of those of younger age, with congenital heart diseases, respiratory distress symptoms/tachypnea, abnormal WBC and CRP results as well as complications were at higher risk for progressing to severe CAP.
- Delayed Cerebral Injury in Adults With Bacterial Meningitis: A Novel Complication of Adjunctive Steroids? [Journal Article]
- CCCrit Care Med 2018 May 09
- CONCLUSIONS: Delayed cerebral injury occurred in 4.1% of adults with bacterial meningitis, and it was associated with the use of adjunctive steroids. Future studies should explore the etiology and prevention of this devastating complication.
- Emergence of quinolone-resistant Shigella flexneri in Italy (March 2017). [Journal Article]
- IJInt J STD AIDS 2018 Jan 01; :956462418769805
- In March 2017, a 45-year-old Italian man who has sex with men was admitted to the Infectious Diseases Department of Trieste Hospital (northeast Italy), because of fever, abdominal pain and dysentery....
In March 2017, a 45-year-old Italian man who has sex with men was admitted to the Infectious Diseases Department of Trieste Hospital (northeast Italy), because of fever, abdominal pain and dysentery. The patient had neither foreign travel history nor sexual contact with non-Italian partners. Stool cultures grew multidrug-resistant Shigella flexneri (resistant to ampicillin, chloramphenicol, streptomycin, tetracycline, trimethoprim, amoxicillin/clavulanic acid and ciprofloxacin) and whole genome sequencing detailed the resistance features. The phylogenetic analysis showed that the strain was unrelated to any previously reported strain. The patient was treated successfully with ceftriaxone. We hereby report the first case of locally-acquired, multidrug-resistant S. flexneri infection in Italy and also the emergence of a new clone.
- Pneumonitis: a serious adverse effect of PD-L1 inhibitors including pembrolizumab. [Journal Article]
- BCBMJ Case Rep 2018 May 07; 2018
- A 70-year-old man presented with breathlessness, cough and fever while receiving pembrolizumab for melanoma. A CT pulmonary angiogram demonstrated small bilateral upper lobe segmental pulmonary embol...
A 70-year-old man presented with breathlessness, cough and fever while receiving pembrolizumab for melanoma. A CT pulmonary angiogram demonstrated small bilateral upper lobe segmental pulmonary emboli with patchy ground-glass opacities and basal perilobular consolidation, in keeping with organising pneumonia. He was treated for community-acquired pneumonia and pulmonary emboli but rapidly deteriorated, with increasing hypoxia and dyspnoea. He was admitted to the intensive care unit for support with continuous positive airway pressure and high flow nasal oxygen. His clinical condition improved once he received high-dose intravenous methylprednisolone to treat pneumonitis. His treatment was continued with a weaning course of high-dose oral steroids, and he was discharged with a persistent oxygen requirement. The patient maintained a requirement for high doses of oral steroids and continued to deteriorate. He was referred to palliative care for symptom management and died a month following hospital discharge, as a result of pneumonitis due to pembrolizumab.
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- Multicentric Castleman's disease in human immunodeficiency virus infection: two case reports. [Journal Article]
- JMJ Med Case Rep 2018 May 05; 12(1):117
- CONCLUSIONS: Considering the importance of differential diagnosis of lymphoid disorders, Castleman's disease is a challenging diagnosis in people living with human immunodeficiency virus/acquired immunodeficiency syndrome and can be easily misdiagnosed when lymphoid disorders are present in the human immunodeficiency virus/acquired immunodeficiency syndrome population due to nonspecific symptoms and signs.