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Unbound Medicine.
(Fixed drug eruptions)
1,075 results
  • Levofloxacin induced bullous fixed drug eruption: a rare case report. [Journal Article]
    Eur J Hosp Pharm. 2020 Dec 18 [Online ahead of print]Sharma A, Baldi A, Sharma DK
  • A 42-year-old male patient visited the outpatient department for follow-up with a history of respiratory tract infection and diabetes mellitus. His main symptom was peeling of his epidermal layer of skin, and bullous fixed drug eruption on the lower and upper limbs and bank region of the body. Following assessment, the patient was prescribed levothyroxine, hydroxychloroquine, levofloxacin, and a …
  • Fixed drug eruptions, bullous drug eruptions, and lichenoid drug eruptions. [Journal Article]
    Clin Dermatol. 2020 Nov - Dec; 38(6):679-692.Cheraghlou S, Levy LL
  • Drug reactions are among the most common reasons for inpatient dermatology consultation. These reactions are important to identify because discontinuation of the offending agent may lead to disease remission. With the rising use of immunomodulatory and targeted therapeutics in cancer care and the increased incidence in associated reactions to these drugs, the need for accurate identification and …
  • Pediatric drug eruptions. [Journal Article]
    Clin Dermatol. 2020 Nov - Dec; 38(6):629-640.Nguyen E, Gabel CK, Yu J
  • Drug eruptions in children are common but in general less studied than their adult counterparts. Aside from having significant impact on the child's health and quality of life, these reactions can limit what medications the patient can receive in the future. Familiarity with pediatric drug eruptions is important for accurate diagnosis and to prevent future recurrence or ineffective therapy. Our c…
  • Drug induced cutaneous manifestations due to treatment of gastrointestinal disorders. [Journal Article]
    Curr Drug Metab. 2020 Nov 16 [Online ahead of print]Lalosevic MS, Lalosevic J, … Stojkovic M
  • Cutaneous manifestations due to drugs used in treatment of gastrointestinal disorders are multiple and common. Adequate diagnosis is of great importance, bearing in mind that therapeutic regimen depends on it. In this review we provided an overview of the most common drug-induced skin lesions with a detailed explanation of disease course, presentation and treatment having in mind that in the rece…
  • Multiple widespread fixed drug eruption caused by rabeprazole. [Case Reports]
    J Postgrad Med. 2020 Apr-Jun; 66(2):105-107.Gupta S, Gupta S, … Yadav A
  • Fixed drug eruption is one of the most common forms of cutaneous adverse drug reactions. Analgesics and antibiotics are the most common drugs causing fixed drug eruption. Here, we report a case of multiple widespread fixed drug eruption caused by rabeprazole.
  • Genital Ulcers: Differential Diagnosis and Management. [Review]
    Am Fam Physician. 2020 03 15; 101(6):355-361.Roett MA
  • Genital ulcers may be located on the vagina, penis, and anorectal or perineal areas and may be infectious or noninfectious. Herpes simplex virus is the most common cause of genital ulcers in the United States. A diagnosis of genital herpes simplex virus infection is made through physical examination and observation of genital lesions. The 2015 Centers for Disease Control and Prevention sexually t…
  • Multiple Fixed Drug Eruption Mimicking Parapsoriasis en Plaque in a Patient with Hepatitis C Virus Infection. [Case Reports]
    Case Rep Dermatol. 2020 Jan-Apr; 12(1):25-32.Katsuta M, Asahina A, Shiohara T
  • Although hepatitis C virus (HCV) infection is often associated with extrahepatic cutaneous manifestations such as lichen planus, it is unclear whether HCV per se or HCV-specific immune responses play a pathophysiological role in the development of HCV-related cutaneous diseases. We recently treated a patient who developed parapsoriasis en plaque-like lesions after ingestion of various drugs. She …
  • Bullous Drug Reactions. [Review]
    Acta Derm Venereol. 2020 02 12; 100(5):adv00057.Mockenhaupt M
  • Bullous drug eruptions are infrequent, but because they pose a challenge both to affected patients and to treating physicians they are considered to be the most severe cutaneous adverse reactions (SCAR). It is important to recognize these conditions and to differentiate them from other clinical entities involving blister formation. There may be early signs and symptoms that indicate a severe bull…
  • Fixed Drug Eruptions: An Update, Emphasizing the Potentially Lethal Generalized Bullous Fixed Drug Eruption. [Review]
    Am J Clin Dermatol. 2020 Jun; 21(3):393-399.Patel S, John AM, … Schwartz RA
  • A fixed drug eruption (FDE) is a relatively common reaction associated with more than 100 medications. It is defined as a same-site recurrence with exposure to a particular medication. The primary approach and treatment for all types of FDEs are to identify and remove the causative agent, often accomplished by a thorough history of medication and other chemical exposures, and possibly prior episo…
  • [Sebotropic drug eruption after ingestion of bee pollen]. [Case Reports]
    Ann Dermatol Venereol. 2020 Feb; 147(2):135-139.Vermersch C, Kerdraon R, … Finon A
  • CONCLUSIONS: The clinical-pathological correlation was consistent with a diagnosis of sebotropic drug reaction induced by the consumption of bee pollen. The diagnosis was based on papular exanthema of the seborrheic zones occurring 2 to 3 weeks after initial intake of the offending substance, with histological evidence of inflammatory necrosis of the sebaceous glands.We report what is to our knowledge the first case of sebotropic drug reaction following ingestion of bee pollen.
  • Autoimmune progesterone dermatitis presenting as fixed drug eruption. [Case Reports]
    BMJ Case Rep. 2019 Dec 01; 12(11)Bhardwaj N, Jindal R, Chauhan P
  • Autoimmune progesterone dermatitis (APD) is a rare disorder that presents as recurrent cyclical cutaneous eruptions during the premenstrual period when progesterone level is elevated. It does not have a specific cutaneous manifestation of its own and presents with a multitude of common cutaneous conditions, thus making it a diagnostic challenge. We describe the case of a young woman who presented…
  • Genital Involvement in Bullous Fixed Drug Eruption. [Journal Article]
    Skinmed. 2019; 17(5):306-309.Zaouak A, Chabchoub I, … Fenniche S
  • Bullous fixed drug eruption (FDE) is a severe reaction due to drug intake and requires specific management in dermatology. The sites of predilection are the lips, trunk, genitalia, and perineal area. The aim of our study was to assess the features and outcomes of bullous FDE with genital involvement through a retrospective study of 18 years (2000-2017) conducted in the Dermatology Department of H…
  • Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction. [Case Reports]
    Einstein (Sao Paulo). 2020; 18:eRC5002.Pereira ARF, Aun MV, … Giavina-Bianchi P
  • The fixed drug eruption is a non-immediate hypersensitivity reaction to drug, characterized by recurrent erythematous or violaceous, rounded, well-defined border plaques, which always appear in the same location every time the culprit drug is administered. The usual practice is to avoid the drug involved and to use a structurally different drug. However, there are situations in which there is no …
  • Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions. [Review]
    Curr Pharm Des. 2019; 25(36):3840-3854.Guvenir H, Arikoglu T, … Misirlioglu ED
  • Drug hypersensitivity reactions are clinically heterogenous ranging from mild to severe. Most drug hypersensitivity reactions are accompanied by cutaneous manifestations. Fever, mucous membrane involvement, large blisters, facial oedema, pustulosis and visceral involvement are clinical features that lead to suspicion of severe adverse drug reactions. Severe cutaneous adverse drug reactions (SCARs…
  • An Update on the Management of Severe Cutaneous Drug Hypersensitivity Reactions. [Review]
    Curr Pharm Des. 2019; 25(36):3881-3901.Gelincik A, Cavkaytar O, Kuyucu S
  • Severe cutaneous drug hypersensitivity reactions involve of different mechanisms , some of which are life-threatening, such as Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, generalized bullous fixed drug eruptions, serum sickness and serum sickness-like reaction and drug-induced vasculitis. T…
  • Contrast-induced generalized bullous fixed drug eruption resembling Stevens-Johnson syndrome. [Case Reports]
    Proc (Bayl Univ Med Cent). 2019 Oct; 32(4):601-602.Gavin M, Sharp L, … Stetson CL
  • A 59-year-old woman with end-stage renal disease presented for suspected Stevens-Johnson syndrome that was ultimately diagnosed as generalized bullous fixed drug eruption (GBFDE) secondary to the administration of iodinated nonpolar radiocontrast. The patient had three previous episodes of a generalized bullous eruption after a thrombectomy, fistulogram, and an arteriovenous fistula revision, all…
  • A pediatric case report of fixed drug eruption related to carmoisine colorant present in paracetamol syrup. [Case Reports]
    Indian J Pharmacol. 2019 Jul-Aug; 51(4):279-281.Panachiyil GM, Babu T, … Doddaiah N
  • Various adverse drug reactions, including hypersensitivity skin reaction after the exposure to carmoisine colorant, have already been reported in the literature. This case report gives the details of a 5-year-old male child with a recurrent fixed drug eruption (FDE) over the neck and trunk after the use of paracetamol syrup containing carmoisine as a colorant. Patch test to the carmoisine coloran…
  • A first case of fixed drug eruption due to Tamsulosin. [Journal Article]
    J Cosmet Dermatol. 2020 May; 19(5):1143-1145.Montazer F, Jahani Amiri K, … Mofarrah R
  • CONCLUSIONS: Our case is a relatively mild form of fixed drug eruption. Therefore it should be kept in mind that a severe cutaneous drug eruption might occur after Tamsulosin administration.
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