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138,810 results
  • c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism. [Journal Article]
    Colloids Surf B Biointerfaces. 2020 Jun 25; 194:111211.Madhyastha H, Madhyastha R, … Maruyama M
  • Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research over the last few years. In the present investigation, we have reported temperature dependent facile synthesis of silver nanoparticles using FDA approved c phycocyanin (cPC). The cPC conjugated silver nanoparticles (AgcPCNPs) were characterized by TEM, Zeta Potential, UV-vis, XPS, FTIR, and CD Spectroscopy.…
  • Effect of plateletpheresis on total platelet count and mean platelet volume: A meta-analysis. [Journal Article]
    J Evid Based Med. 2020 Jul 02 [Online ahead of print]Gil-Betancur A, Mantilla-Gutierrez CY, Cardona-Arias JA
  • CONCLUSIONS: Platelet donation by apheresis reduces platelet count and MPV in donors, which is detrimental to the purposes of the procedure; although the decrease is not clinically significant for the donor or the recipient. This demonstrates the need for subsequent studies to evaluate variables, such as donation frequency and donation intervals, should be considered to evaluate if the reported decrease is easily compensated, without adverse consequences for donors, or if modifications in donor selection criteria are required.
  • Landscape of Oncology Clinical Trials in Africa. [Journal Article]
    JCO Glob Oncol. 2020 Jun; 6:932-941.Odedina FT, Shamley D, … Askins N
  • CONCLUSIONS: The paucity of clinical trials in Africa will continue to magnify the global disparities of cancer in the African population. Clinical trials are needed to ensure therapeutic interventions are safe and effective in the African population. In the era of personalized and precision health, it no longer suffices to assume that drugs developed in North America, Europe, or Asia will be effective in the African population.
  • Operational Strategies for Clinical Trials in Africa. [Journal Article]
    JCO Glob Oncol. 2020 Jun; 6:973-982.Graef KM, Okoye I, … Odedina FT
  • CONCLUSIONS: The four programs are anticipated to catalyze the involvement of more African health care sites in cancer clinical trials, enroll a greater number of African patients with cancer in those trials, and, ultimately, reverse Africa's growing cancer incidence and mortality rates. Each program acts as a blueprint for organizations-whether government, academic, or industry-seeking to address the summits' recommendations and increase Africa's contributions to and active participation in clinical research.
  • Predictors of Post-Thrombotic Syndrome in Pediatric Thrombosis: A Systematic Review and Meta-Analysis of the Literature. [Journal Article]
    J Thromb Haemost. 2020 Jul 02 [Online ahead of print]Engel ER, Nguyen ATH, … Betensky M
  • CONCLUSIONS: Twelve studies (n= 1,160 patients) met criteria for inclusion. Ninety-three percent of patients with an extremity DVT(n=1076) were assessed for PTS. PTS developed in 40% (n=434) of these patients. Central venous catheter-associated DVT (odds ratio [OR] 1.8, 95% CI 1.08-2.98), complete veno-occlusion (OR 1.89, 95% CI 1.04-3.46), and incomplete DVT resolution (OR 2.07, 95% CI 1.4-3.07) were identified as candidate prognostic factors for pediatric PTS. These findings should be interpreted in the context of the heterogeneity of the included studies and the limitations of current pediatric PTS assessment tools. Further, the predictive value of these prognostic factors will need to be validated in future collaborative prospective multicenter studies that maximize the homogeneity of pediatric DVT patients.
  • Computational Identification of Kinases That Control Axon Growth in Mouse. [Journal Article]
    SLAS Discov. 2020 Jul 02 [Online ahead of print]Devkota P, Danzi MC, … Wuchty S
  • The determination of signaling pathways and transcriptional networks that control various biological processes is a major challenge from both basic science and translational medicine perspectives. Because such analysis can point to critical disease driver nodes to target for therapeutic purposes, we combined data from phenotypic screening experiments and gene expression studies of mouse neurons t…
  • The Role of Systemic Antimicrobials in the Treatment of Endophthalmitis: A Review and an International Perspective. [Review]
    Ophthalmol Ther. 2020 Jul 01 [Online ahead of print]Grzybowski A, Turczynowska M, … Flynn HW
  • CONCLUSIONS: Systemic antimicrobials may be particularly beneficial in patients with certain types of endophthalmitis; as such, they are standard treatment in the management of endogenous endophthalmitis (fungal and bacterial) and also widely used for prophylaxis and treatment of open-globe injuries. Although systemic antimicrobials are used in some patients with acute-onset postoperative endophthalmitis following cataract surgery, the literature generally does not support this practice. It is noted that there are currently no randomized clinical trials demonstrating a benefit of systemic antibiotics for any category of endophthalmitis.
  • Firearm Use in Violent Crime: Examining the Role of Premeditation and Motivation in Weapon Choice. [Journal Article]
    J Prim Prev. 2020 Jul 01 [Online ahead of print]Pizarro JM, Zgoba KM, Pelletier KR
  • Although there is a plethora of research documenting the relationship between firearms and violence, we know little about the influence of offenders' motivation and premeditation as they relate to the choice of weapon for the commission of a violent crime. In this study, we examined a sample of 375 violent crime inmates incarcerated in the New Jersey Department of Corrections. We addressed two re…
  • Cardiac magnetic resonance imaging in Chagas' disease: a parallel with electrophysiologic studies. [Review]
    Int J Cardiovasc Imaging. 2020 Jul 01 [Online ahead of print]Duran-Crane A, Rojas CA, … Medina HM
  • Chagas' disease (CD), caused by the parasite Trypanosoma cruzi, is the leading cause of cardiac disability from infectious diseases in Central and South America. The disease progresses through an extended, asymptomatic form characterized by latency without clinical manifestations into a symptomatic form with cardiac and gastro-intestinal manifestations. In the terminal phase, chronic Chagas' myoc…
  • Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma. [Journal Article]
    Int J Hematol. 2020 Jul 01 [Online ahead of print]Izutsu K, Kato K, … Akashi K
  • Duvelisib is a novel dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ and -γ. This single-arm, multicenter phase I study investigated its safety, pharmacokinetics, and preliminary efficacy in Japanese patients with relapsed or refractory lymphoma. Duvelisib was administered orally twice daily at 25 mg in 28-day cycles. Seven patients, comprising 4 with follicular lymphoma (FL), 2 with diffuse…
  • Inclusion of transgender and gender diverse health data in cancer biorepositories. [Journal Article]
    Contemp Clin Trials Commun. 2020 Sep; 19:100597.Jones NC, Otto AK, … Schabath MB
  • Biobanks have the potential to be robust resource for understanding potential cancer risks associated with gender-affirming interventions. In this narrative review, we synthesized the current published literature regarding the inclusion of TGD health data in cancer biorepositories and cancer research conducted on biospecimens. Of the 6986 initial results, 153 (2.2%) assessed the biological effect…
  • Educational Case: Smooth Muscle Tumors of the Uterus. [Journal Article]
    Acad Pathol. 2020 Jan-Dec; 7:2374289520932285.Brioso Rubio X, Beal SG, … Kresak J
  • The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objective…
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