- Mobile Vaccine Clinics for Patients With Serious Mental Illness and Health Care Workers in Outpatient Mental Health Clinics. [Journal Article]Psychiatr Serv. 2023 Feb 08 [Online ahead of print]PS
- CONCLUSIONS: Mobile vaccine clinics can improve vaccine access for patients and health care workers in community mental health settings and can be cost-effective.
- Publisher Full Text (DOI)
- Generation of high cross-presentation ability human dendritic cells by combination of interleukin 4, interferon β and GM-CSF. [Journal Article]Cent Eur J Immunol. 2022; 47(2):125-138.CE
- Dendritic cell (DC)-based immunotherapies have been utilized for the treatment of numerous diseases. However, the conventional generation strategies of DCs in vitro require 7 days and these DCs showed an unsatisfactory function, which prompted us to explore new approaches. We found that in vitro culture of human CD14+ cells, in the medium containing granulocyte-macrophage colony-stimulating facto…
- PMC Free PDF
- Clinical Research: A Review of Study Designs, Hypotheses, Errors, Sampling Types, Ethics, and Informed Consent. [Review]Cureus. 2023 Jan; 15(1):e33374.C
- Recently, we have been noticing an increase in the emergence and re-emergence of microbial infectious diseases. In the previous 100 years, there were several incidences of pandemics caused by different microbial species like the influenza virus, human immunodeficiency virus (HIV), dengue virus, severe acute respiratory syndrome Coronavirus (SARS-CoV), middle east respiratory syndrome coronavirus …
- PMC Free PDF
- Arrayed Imaging Reflectometry monitoring of anti-viral antibody production throughout vaccination and breakthrough Covid-19. [Journal Article]PLoS One. 2023; 18(2):e0277846.Plos
- Immune responses to COVID-19 infection and vaccination are individual and varied. There is a need to understand the timeline of vaccination efficacy against current and yet to be discovered viral mutations. Assessing immunity to SARS-CoV-2 in the context of immunity to other respiratory viruses is also valuable. Here we demonstrate the capability of a fully automated prototype Arrayed Imaging Ref…
- Publisher Full Text (DOI)
- Amino Acid Variation at Hemagglutinin Position 193 Impacts the Properties of H9N2 Avian Influenza Virus. [Journal Article]J Virol. 2023 Feb 07 [Online ahead of print]JV
- Despite active control strategies, including the vaccination program in poultry, H9N2 avian influenza viruses possessing mutations in hemagglutinin (HA) were frequently isolated. In this study, we analyzed the substitutions at HA residue 193 (H3 numbering) of H9N2 and investigated the impact of these mutations on viral properties. Our study indicated that H9N2 circulating in the Chinese poultry h…
- Publisher Full Text (DOI)
- JMM Profile: Swine influenza A virus: a neglected virus with pandemic potential. [Journal Article]J Med Microbiol. 2023 Jan; 72(1)JM
- Swine influenza is an acute respiratory disease of swine caused by swine influenza A virus (SwIAV). The ability of SwIAV to spread bidirectionally from animals to humans (zoonotic), and from humans to animals (reverse zoonotic), drives coinfection that can result in gene segment exchange and elevates the risk of generating viruses with pandemic potential. Compared to human-origin influenza A viru…
- Publisher Full Text (DOI)
- Conductive Thread-Based Immunosensor for Pandemic Influenza A (H1N1) Virus Detection. [Journal Article]ACS Appl Mater Interfaces. 2023 Feb 07 [Online ahead of print]AA
- Infectious agents such as viruses pose significant threats to human health, being transmitted via direct contact as well as airborne transmission without direct contact, thus requiring rapid detection to prevent the spread of infectious diseases. In this study, we developed a conductive thread-based immunosensor (CT-IS), a biosensor to easily detect the presence of airborne viruses. CT-IS utilize…
- Publisher Full Text (DOI)
- JMM Profile: Japanese encephalitis virus: an emerging threat. [Journal Article]J Med Microbiol. 2022 Dec; 71(12)JM
- Japanese encephalitis (JE) is an infection that occurs predominantly in Asia and the Pacific Islands. It is transmitted by mosquito bites, with the main vector being Culex tritaeniorhynchus, and is maintained in enzootic cycles involving pigs, wild birds and mosquitoes. JE is caused by infection with Japanese encephalitis virus (JEV), a zoonotic pathogen that also causes disease in mammals such a…
- Publisher Full Text (DOI)
- Interventions to Increase Uptake of Influenza Vaccination in Pregnancy: A Systematic Review and Meta-analysis. [Review]Int J Gynaecol Obstet. 2023 Feb 06 [Online ahead of print]IJ
- CONCLUSIONS: We found that several educational interventions for pregnant women can effectively increase influenza vaccination uptake in this population. Specifically, pamphlets, websites, and brief one-to-one education can be effective tools.
- Publisher Full Text (DOI)
- An algorithm to estimate the real time secondary infections in sub-urban bus travel: COVID-19 epidemic experience at Chennai Metropolitan city India. [Journal Article]Virusdisease. 2023 Feb 02 [Online ahead of print]V
- Globalization, global climatic changes, and human behavior pose threats to highly pathogenic avian influenza (HPAI) virus spillover from animals to human. Current SARS-CoV2 transmission continues in several countries despite drastic reduction in COVID-19 cases following world-wide containment measures including RNA vaccines. China reimposed lockdown in November 2022 following the surge in commerc…
- PMC Free PDF
- The clinical outcomes of COVID-19 critically ill patients co-infected with other respiratory viruses: a multicenter, cohort study. [Journal Article]BMC Infect Dis. 2023 Feb 06; 23(1):75.BI
- CONCLUSIONS: Critically ill patients with COVID-19 who were concomitantly infected with other respiratory viruses had comparable 30-day mortality to those not concomitantly infected. Further proactive testing and care may be required in the case of co-infection with respiratory viruses and COVID-19. The results of our study need to be confirmed by larger studies.
- Publisher Full Text (DOI)
- Study on the prediction effect of a combined model of SARIMA and LSTM based on SSA for influenza in Shanxi Province, China. [Journal Article]BMC Infect Dis. 2023 Feb 06; 23(1):71.BI
- CONCLUSIONS: The fitting and prediction performances of the SSA-SARIMA-LSTM model were better than those of the SARIMA and the SARIMA-LSTM models. Generally speaking, we can apply the SSA-SARIMA-LSTM model to the prediction of influenza, and offer a leg-up for public policy.
- Publisher Full Text (DOI)
- Microbiota-derived acetate enhances host antiviral response via NLRP3. [Journal Article]Nat Commun. 2023 Feb 06; 14(1):642.NC
- Pathogenic viral infections represent a major challenge to human health. Host immune responses to respiratory viruses are closely associated with microbiome and metabolism via the gut-lung axis. It has been known that host defense against influenza A virus (IAV) involves activation of the NLRP3 inflammasome, however, mechanisms behind the protective function of NLRP3 are not fully known. Here we …
- Publisher Full Text (DOI)
- Real-world uptake of COVID-19 vaccination among individuals expressing vaccine hesitancy: A registry-linkage study. [Journal Article]Vaccine. 2023 Feb 01 [Online ahead of print]V
- CONCLUSIONS: Willingness to receive COVID-19 vaccination was an imperfect predictor of real-world vaccine uptake. Improved messaging about COVID-19 vaccination regardless of previous SARS-CoV-2 infection status may help improve uptake.
- Publisher Full Text (DOI)
- Improving outpatient care in adult inflammatory bowel disease: effect of implementation of a reminder checklist in the electronic health records (IBD-ERS)-a pilot study. [Journal Article]BMJ Open Qual. 2023 Feb; 12(1)BO
- Studies have shown that patients with inflammatory bowel disease (IBD) do not receive age appropriate preventive care services at the same rate as the general population. Providers extract information on preventive measures compliance by chart review, discussion with patients or deferment to primary care providers to ensure and document compliance. The aim of this pilot study was to evaluate the …
- Publisher Full Text (DOI)
- Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses. [Journal Article]PLoS Pathog. 2023 Feb 06; 19(2):e1011135.PP
- Global spread and regional endemicity of H5Nx Goose/Guangdong avian influenza viruses (AIV) pose a continuous threat for poultry production and zoonotic, potentially pre-pandemic, transmission to humans. Little is known about the role of mutations in the viral neuraminidase (NA) that accompanied bird-to-human transmission to support AIV infection of mammals. Here, after detailed analysis of the N…
- Publisher Full Text (DOI)
- Long Short-term Memory-Based Prediction of the Spread of Influenza-Like Illness Leveraging Surveillance, Weather, and Twitter Data: Model Development and Validation. [Journal Article]J Med Internet Res. 2023 Feb 06; 25:e42519.JM
- CONCLUSIONS: The superiority of the TL-based model, which considers Twitter data, weather data, and ILI surveillance data, reflects the potential of alternative public sources to enhance accurate and reliable prediction of ILI spread. Despite its focus on the use case of Greece, the proposed approach can be generalized to other locations, populations, and social media platforms to support the surveillance of infectious diseases with the ultimate goal of reinforcing preparedness for future epidemics.
- Publisher Full Text (DOI)
- Acoustic Characteristics of Short Vowels by Normal Nepali Young Adults. [Journal Article]
- CONCLUSIONS: Before implementing these norms in clinical set up we must consider that these values are developed for the adults whose L1 is Nepali language and the software used for the establishment of norms was Praat.
- Publisher Full Text (DOI)
- Role of Polymerase Chain Reaction-Based Diagnosis of Respiratory Viruses in Febrile Neutropenic Patients. [Journal Article]
- Background Neutropenic patients are commonly affected by respiratory infections, whereas respiratory viral infections causing high morbidity and mortality are routinely diagnosed in developing countries like India. Our study aimed to investigate the prevalence of respiratory viral infections in pediatric cancer patients with febrile neutropenia. Methods This prospective study was performed on 45 …
- PMC Free PDF
- Attenuation and Degeneration of SARS-CoV-2 Despite Adaptive Evolution. [Review]
- The evolution of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has followed similar trends as other RNA viruses, such as human immunodeficiency virus type 1 and the influenza A virus. Rapid initial diversification was followed by strong competition and a rapid succession of dominant variants. Host-initiated RNA editing has been the primary mechanism for introducing mutations. A sig…
- PMC Free PDF
- N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals. [Journal Article]
- Clade 2.3.4.4 avian H5Ny viruses, namely H5N2, H5N6, and H5N8, have exhibited unprecedented intercontinental spread in poultry. Among them, only H5N6 viruses are frequently reported to infect mammals and cause serious human infections. In this study, the genetic and biological characteristics of surface hemagglutinin (HA) from clade 2.3.4.4 H5Ny avian influenza viruses (AIVs) were examined for ad…
- PMC Free PDF
- [Annual update of pulmonary infectious diseases in 2022]. [Review]Zhonghua Jie He He Hu Xi Za Zhi. 2023 Feb 12; 46(2):168-171.ZJ
- In 2022, coronavirus disease 2019 (COVID-19) remains rampant across the world. Several remarkable studies concerning pulmonary infectious diseases have been published during this pandemic. This review summarized the representative academic and translational medical progress over the past year (from October 1, 2021, to September 30, 2022), including COVID-19, community/hospital-acquired pneumonia,…
- Publisher Full Text (DOI)
- Determination of the synergistic anti-influenza effect of Huangqin Su tablet and Oseltamivir and investigation of mechanism of the tablet based on gut microbiota and network pharmacology. [Journal Article]
- Huangqin Su (HQS) tablet is mainly composed of baicalein which has been evaluated for its ability to inhibit influenza. The present study aimed to investigate the effect of HQS and oseltamivir phosphate (OS) (single or combination therapy) on influenza-induced acute pneumonia in male and female ICR mice. The regulatory effect of HQS on gut microbiota was also studied by using 16 s rDNA sequencing…
- PMC Free PDF
- Evaluation of the cobas Liat detection test for SARS-CoV-2 and influenza viruses following the emergence of the SARS-CoV-2 Omicron variant. [Journal Article]
- CONCLUSIONS: The LiatCOVID/flu assay shows an acceptable performance in the detection of SARS-CoV-2 and influenza viruses using NPS samples.
- PMC Free PDF
- Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites. [Journal Article]
- CONCLUSIONS: The discrepancy in M2-dependence emphasizes the importance of M2 in human influenza A virus pathogenicity, which leads to subtype-specific evolution. Our findings provide insights into virus adaptation processes in humans and highlights splicing regulation as a potential antiviral target.
- PMC Free PDF
- Pandemic preparedness: five minutes with . . . Katie Doores. [Journal Article]BMJ. 2023 Feb 03; 380:p287.BMJ
- Publisher Full Text (DOI)
- Unravelling the mechanisms of drugs partitioning phenomena in micellar systems via NMR spectroscopy. [Journal Article]J Colloid Interface Sci. 2023 Jan 20; 638:135-148.JC
- Despite extensive use of micelles in materials and colloidal science, their supramolecular organization as well as host-guest interactions within these dynamic assemblies are poorly understood. Small guest molecules in the presence of micelles undergo constant exchange between a micellar aggregate and the surrounding solution, posing a considerable challenge for their molecular level characterisa…
- Publisher Full Text (DOI)
- Does prior vaccination affect the immune response to seasonal influenza vaccination among older adults? Findings from a prospective cohort study in a Northeastern Province of Thailand. [Journal Article]
- CONCLUSIONS: Influenza vaccination elicited good humoral response in older Thai adults. While seroconversion seemed attenuated in persons previously vaccinated for influenza A(H1N1)pdm09 (the only vaccine strain not to change), this was not apparent for influenza A(H3N2) and B, and prior vaccination was not associated with any inhibition in seroprotection.
- PMC Free PDF
- Sex-specific effect of urinary metabolites of polycyclic aromatic hydrocarbons on thyroid profiles: results from NHANES 2011-2012. [Journal Article]Environ Sci Pollut Res Int. 2023 Feb 03 [Online ahead of print]ES
- The current study aims to evaluate the associations between 10 urinary polycyclic aromatic hydrocarbon (PAH) metabolites and thyroid profiles. The levels of 10 PAH metabolites and thyroid profiles were obtained from National Health and Nutrition Examination Survey (NHANES) 2011-2012. Spearman analysis was utilized to evaluate the correlation coefficients among these 10 PAH metabolites. Multivaria…
- Publisher Full Text (DOI)
- Convalescent Plasma Therapy against COVID-19: An update on the changing facets of the ongoing Pandemic. [Journal Article]Curr Pharm Biotechnol. 2023 Feb 02 [Online ahead of print]CP
- The severe respiratory infections in the current pandemic coronavirus disease-19 (COVID-19) have influenced more or less every human life. The first person to get infected with this virus was reported in the capital of Hubei province (Wuhan), China, in late December 2019. Since the disease has been declared a pandemic, research scholars and experts have been manufacturing new vaccines or targeted…
- Publisher Full Text (DOI)