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Unbound Medicine.
(Friedewald equation)
139 results
  • Comparison of Novel Equations for Estimating Low-Density Lipoprotein Cholesterol in Patients Undergoing Coronary Angiography. [Journal Article]
    J Atheroscler Thromb. 2020 Jul 02 [Online ahead of print]Zafrir B, Saliba W, Flugelman MY
  • CONCLUSIONS: Both Martin and Sampson LDL-C estimates displayed significant proportion of upward discordance with reclassification to higher LDL-C categories compared to Friedewald formula, particularly in patients with elevated triglycerides and low LDL-C, a population in whom more accurate estimation of LDL-C is required. Further studies are warranted to validate the recently developed Sampson equation with comparison to Martin method that tended to more significantly overestimate LDL-C.
  • More accurate LDL-C calculation: Externally validated, guideline endorsed. [Journal Article]
    Clin Chim Acta. 2020 Jul; 506:149-153.Brownstein AJ, Martin SS
  • Low density lipoprotein-cholesterol (LDL-C) serves as the primary target of therapy for preventing atherosclerotic cardiovascular disease (ASCVD). Recently released European and American guidelines on lipid management recommend attaining very low LDL-C levels (<1.8 mmol/L or even lower) in high and very-high risk patients. Therefore, utilizing an accurate means for determining LDL-C, especially a…
  • Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition. [Journal Article]
    PLoS Biol. 2019 12; 17(12):e3000572.Kettunen J, Holmes MV, … Ala-Korpela M
  • Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on detailed lipoprotein measures and compare those to genetic inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). We used an allele associated with lower CE…
  • Validation of the novel Martin method for LDL cholesterol estimation. [Journal Article]
    Clin Chim Acta. 2019 Sep; 496:68-75.Petridou E, Anagnostopoulos K
  • CONCLUSIONS: We found that TG > 200 mg/dl is a sensible threshold value since it is a saddle point for the standard error of the regression. For Bayesian linear regression, the results were inconclusive. When the LDL values were used for classification of CHD, it turned out that the novel method was better than the Friedewald equation at correctly classifying LDL levels for CHD risk assessment.
  • Update on low-density lipoprotein cholesterol quantification. [Journal Article]
    Curr Opin Lipidol. 2019 08; 30(4):273-283.Chung S
  • β-Quantification is considered the reference measurement procedure for low-density lipoprotein cholesterol (LDL-C). However, this technique is time-consuming and thus is inappropriate for routine clinical practice. Therefore, the Friedewald equation or homogeneous assays have been widely utilized. As several pitfalls exist with these two methods, a novel method for estimating LDL-C was developed …
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