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18,580 results
  • In-vivo techniques for determining nephron number. [Journal Article]
    Curr Opin Nephrol Hypertens 2019Denic A, Elsherbiny H, Rule AD
  • CONCLUSIONS: Currently, there is no accurate and well tolerated method for determining nephron number in living humans. A clinically useful method may allow GFR to be replaced by its more relevant determinants: nephron number and single nephron GFR. This could revolutionize nephrology by separating the measurement of chronic disease (nephron loss) from more reversible hemodynamic effects (nephron hyperfiltration/hypofiltration).
  • Plasma uric acid and renal hemodynamics in type 2 diabetes patients. [Journal Article]
    Nephrology (Carlton) 2019Suijk DLS, Smits MM, … van Raalte DH
  • CONCLUSIONS: PUA was negatively associated to GFR, ERPF but positively related to ERVR in T2D patients without overt renal impairment. PUA-related increase in ERVR may be related to increased arterial afferent tone, which may put the kidney at risk for renal damage through ischemia. This article is protected by copyright. All rights reserved.
  • Vitamin D, 1,25-Dihydroxyvitamin D, FGF23, and Graft Function after Renal Transplantation. [Journal Article]
    Indian J Nephrol 2019 Jul-Aug; 29(4):242-247Mehrotra S, Sharma RK, Patel MR
  • Vitamin-D has immuno-modulatory properties besides its role in mineral and bone disorder (MBD) and could have a role in allograft outcome. Fifty-two chronic kidney disease patients on dialysis going for transplantation were prospectively studied before and after renal transplantation. FGF23, 25(OH) vitamin D, 1,25-Dihydroxyvitamin D, PTH, serum Ca, serum PO4, and e-GFR status were evaluated. Vita…
  • Urinary exploration of metabolism: nutrition assessment, urolithiasis and tubulopathy. [Journal Article]
    Ann Biol Clin (Paris) 2019; 77(4):381-389Machon C, Bargnoux AS, … Frochot V
  • The SFBC working group aimed to deal with biological tests outside the french nomenclature that may be useful in the context of urinary exploration of metabolism. This section will be divides into three parts: 1) nutritional assessment using urinary urea; 2) metabolic assessment of urolithiasis; 3) exploration of tubulopathies. National and international recommendations support the evaluation of …
  • Estimation of glomerular filtration rate using cystatin C. [Journal Article]
    Ann Biol Clin (Paris) 2019; 77(4):375-380Bargnoux AS, Barguil Y, … Cristol JP
  • Blood concentration of cystatin C is independent of muscle mass and tubular secretion. It can be used, in the absence of a reference method, as an alternative marker to creatinine for the evaluation of renal function and the estimation of glomerular filtration rate (GFR). Both particle-enhanced immunonephelemetry (PENIA) or immunoturbidimetry (PETIA) methods are available to determine cystatin C.…
  • Measurement of glomerular filtration rate using a reference method. [Journal Article]
    Ann Biol Clin (Paris) 2019; 77(4):371-374Chardon L, Dubourg L, … Mariat C
  • Direct measurement methods of glomerular filtration rate (GFR) are considered as the gold standard to assess kidney function. Following the withdrawal of the Proinuline Serb® specialty by the French National Health Surveillance Agency, iohexol remains the most suitable marker to replace inulin as the marker for GFR in France. The assay is performed by high performance liquid chromatography (HPLC)…
  • Should we abandon GFR in the decision to initiate chronic dialysis? [Journal Article]
    Pediatr Nephrol 2019Preka E, Rees L
  • The best time to start chronic dialysis during the course of CKD stage 5 is controversial. The first randomised control trial of dialysis initiation either in early or late CKD stage 5 in adults (IDEAL study), and 3 studies from the two largest paediatric registries, the U.S. Renal Data System (USRDS) and the European Society of Paediatric Nephrology (ESPN) Registry, have now provided us with evi…
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