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19,228 results
  • A case of acute renal failure with multiple origins of the renal injury. [Journal Article]
    CEN Case Rep. 2020 Jul 04 [Online ahead of print]Micarelli D, Cristi E, … Feriozzi S
  • Acute kidney injury (AKI) is an abrupt and usually reversible decline in the glomerular filtration rate (GFR). Patients with AKI must be evaluated promptly to determine cause. Different disorders can BE associated with AKI, and biopsy is the most accurate instrument for diagnosis of different types of diseases. We report a case of 69-year-old woman. In history, type II diabetes mellitus and arter…
  • Association between breed and renal biomarkers of glomerular filtration rate in dogs. [Journal Article]
    Vet Rec. 2020 Jul 01 [Online ahead of print]Coyne M, Szlosek D, … Olavessen L
  • CONCLUSIONS: Evidence of decreased GFR occurred commonly in older dogs of most breeds, especially geriatric dogs greater than 10 years of age, but there were some exceptions, with more significant changes affecting younger animals of several breeds. The combination of SDMA and Cr identified more cases of decreased GFR than either SDMA or Cr alone.
  • Neonatal and Maternal Outcomes among Women with Glomerulonephritis. [Journal Article]
    Am J Nephrol. 2020 Jul 01 [Online ahead of print]Madej A, Mazanowska N, … Pietrzak B
  • CONCLUSIONS: Women with GN are a risk factor of adverse pregnancy outcomes. As pregnancy complications are more prevalent across all the CKD stages, even in patients with near-normal kidney function, they require specialized care. It might be advisable to screen pregnant women for the presence of CKD, as especially in the early stage, it is often asymptomatic. Both hypertension and proteinuria are risk factors for neonatal and maternal complications.
  • Effects of low-dose meloxicam in cats with chronic kidney disease. [Journal Article]
    J Feline Med Surg. 2020 Jun 29 [Online ahead of print]KuKanich K, George C, … Grauer GF
  • CONCLUSIONS: No decline in renal excretory function was observed when meloxicam was administered to cats with CKD. However, gastrointestinal adverse effects were observed, and cats that received meloxicam had greater proteinuria at 6 months than cats that received placebo. As proteinuria is associated with negative outcomes (progression of azotemia and hypertension) in cats with CKD, this finding suggests that meloxicam should be used with caution in cats with CKD and UPC monitored. Until further research is available, clinicians should weigh the risk of potential increased proteinuria against quality of life benefits when considering meloxicam for analgesia in cats with renal disease.
  • Bardoxolone methyl: drug development for diabetic kidney disease. [Review]
    Clin Exp Nephrol. 2020 Jun 27 [Online ahead of print]Kanda H, Yamawaki K
  • Bardoxolone methyl activates the Keap1/Nrf2 system that plays an important role in defense responses against oxidative stress. Importantly, bardoxolone methyl has demonstrated increases in estimated glomerular filtration rate (eGFR) in patients with diabetic kidney disease (DKD) in clinical studies. However, an overseas Phase 3 study of bardoxolone methyl in patients with stage G4 DKD was prematu…
  • Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes. [Journal Article]
    N Engl J Med. 2020 06 25; 382(26):2493-2503.Doria A, Galecki AT, … PERL Study Group
  • CONCLUSIONS: We found no evidence of clinically meaningful benefits of serum urate reduction with allopurinol on kidney outcomes among patients with type 1 diabetes and early-to-moderate diabetic kidney disease. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; PERL number, NCT02017171.).
  • PCSK9 and HS-CRP Predict Progression of Aortic Stenosis in Patients with Stable Coronary Artery Disease. [Journal Article]
    J Cardiovasc Transl Res. 2020 Jun 23 [Online ahead of print]Aceña Á, Franco Peláez JA, … Tuñón J
  • It is essential to study the factors associated with the evolution of aortic stenosis progression (ASP) to develop therapies that could reduce it. We studied 283 patients 6 months after acute coronary syndrome (ACS). ASP was defined as an increase in the maximum aortic velocity of at least 0.5 m/s between the echocardiogram performed during ACS hospitalization and the last one recorded in the ele…
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