- Characteristics and predictors for gastrointestinal hemorrhage among adult patients with dengue virus infection: Emphasizing the impact of existing comorbid disease(s). [Journal Article]
- PlosPLoS One 2018; 13(2):e0192919
- CONCLUSIONS: Our study is the first to disclose that end stage renal disease and previous stroke, with additional comorbidities, were strongly significant associated with the risk of GI bleeding in patients with dengue virus infection. Identification of these risk factors can be incorporated into the patient assessment and management protocol of dengue virus infection to reduce its mortality.
- The significance of OLGA and OLGIM staging systems in the risk assessment of gastric cancer: a systematic review and meta-analysis. [Review]
- GCGastric Cancer 2018 Feb 19
- CONCLUSIONS: This correlation implies that close and frequent monitoring of such high-risk patients is necessary to facilitate timely diagnosis of gastric cancer.
- [Histological complete response to neoadjuvant therapy in advanced gastric carcinoma. A case report and review of literature]. [Journal Article]
- RGRev Gastroenterol Peru 2017 Oct-Dec; 37(4):379-386
- This communication describes the first case in the Regional Institute of Neoplastic Diseases "Luis Pinillos Ganoza" IREN North in which a patient with advanced gastric carcinoma showed complete respo...
This communication describes the first case in the Regional Institute of Neoplastic Diseases "Luis Pinillos Ganoza" IREN North in which a patient with advanced gastric carcinoma showed complete response to neoadjuvant histopathologic. We describe the case of a patient woman of 70 years old with histopathologic diagnosis of moderately differentiated tubular gastric adenocarcinoma, locally advanced associated with images of perigastric lymphadenopathy and loss of the interface between gastric tumor, hepatic hilum and gallbladder. After 6 courses of neoadjuvant chemotherapy with FOLFOX scheme - 4 to 80%, an almost complete response from the point of tomographic view is obtained, so the patient is underwent to distal subtotal gastrectomy lymphadenectomy D2 more gastrojejunoanastomosis Billroth II termino lateral type Hofmeister Finsterer verifying on microscopic examination of surgical specimen only acute and chronic gastritis with mucous areas and reactive changes. No feasible malignancy is observed. Lymph nodes: 0/33. Commenting on the case, a review of recent relevant literature is realized.
- vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis. [Journal Article]
- JMJ Med Microbiol 2018 Jan 10
- CONCLUSIONS: H. pylori strains carrying vacA s1m1, cagA+and babA2-genotypes were the most prevalent in patients with chronic gastritis from the south of Mexico. In the cagA+strains, the EPIYA-ABC motif was the most common.
- Management of Helicobacter pylori in Piedmont, Italy. [Journal Article]
- MGMinerva Gastroenterol Dietol 2018 Feb 19
- Helicobacter pylori (H. pylori) is a Gram-negative bacterium, usually acquired during childhood, whose natural habitat is the gastric lumen. H. pylori is accepted as the most important cause of gastr...
Helicobacter pylori (H. pylori) is a Gram-negative bacterium, usually acquired during childhood, whose natural habitat is the gastric lumen. H. pylori is accepted as the most important cause of gastritis and peptic ulcer in humans. Nevertheless, its important role in the pathogenesis of gastric cancer as well as in several extra-gastroduodenal diseases has been confirmed. The aim of this work is to discuss, for the first time in a single article, all publications concerning H. pylori infection arising from Piedmont region, Italy, where in 1893 Giulio Bizzozero was the first who observed and described spiral organisms in the stomach of animal models. A systematic review of all publications on the management of H. pylori in adults in Piedmont, based on a PubMed and a Scopus research from 1965 to 2017 was performed. The discussed aspects are the epidemiology, the study on gastric and extragastric diseases related to H. pylori, the diagnostic methods, the treatment of H. pylori infection, and the possibility of reinfection. In conclusions, with almost 70 publications, Piedmont has proudly maintained the tradition of the father of the H. pylori.
- Benign and malignant gastroduodenal diseases associated with Helicobacter pylori: a narrative review and personal remarks in 2018. [Journal Article]
- MGMinerva Gastroenterol Dietol 2018 Feb 19
- The subject of Helicobacter pylori continues to elicit worldwide interest in many research fields. Epidemiological data suggest that the prevalence of the infection is decreasing in Western/developed...
The subject of Helicobacter pylori continues to elicit worldwide interest in many research fields. Epidemiological data suggest that the prevalence of the infection is decreasing in Western/developed countries and even in some developing regions, but this is masked by the high prevalence in the most populous regions. Chronic gastritis, caused invariably by the bacterium, was again classified in Kyoto and Helicobacter pylori-associated gastritis was included as a distinct entity. The prevalence of peptic ulcers is decreasing, but bleeding ulcers are a challenging problem, with stable mortality levels even in the endoscopic era. With the extended use of endoscopy, gastric polyps have become more prevalent: some are associated with the infection, some are not. Autoimmune and Helicobacter-induced gastritis can share common pathogenetic mechanisms. Gastric cancer is ranked highly on mortality lists worldwide. Its surgical treatment has registered some progress though. Little, if any improvement has been achieved in the medical treatment of advanced gastric cancer. With proper organization, gastric cancer seems a preventable disease. In spite of many guidelines, the Pan-European registry of Helicobacter pylori management shows that eradication rates obtained in many places are suboptimal. A new therapeutic regimen was compiled with promising pilot results. The results obtained with vonaprazan are limited to Asia. New avenues of both antibiotic and non-antibiotic treatments are expected to accelerate the eradication of this ulcerogenic and carcinogenic bacterium.
- The phenotypic heterogeneity of hereditary diffuse gastric cancer: the report of one family with early-onset disease. [Journal Article]
- GEGastrointest Endosc 2018 Feb 15
- CONCLUSIONS: HDGC is a heterogeneous disease regarding clinical behavior, endoscopic findings, histopathologic features, and immunophenotypic/molecular profile. The presence of bizarre, pleomorphic cells in endoscopic biopsy specimens is suggestive of advanced disease and should prompt clinical intervention. The involvement of a full multidisciplinary team is essential for the management of these patients.
- Distinct chemopreventive effects of aspirin in diffuse and intestinal-type gastric cancer. [Journal Article]
- CPCancer Prev Res (Phila) 2018 Feb 16
- CONCLUSIONS: Aspirin may have distinct effects between intestinal-type and diffuse-type gastric cancer development.
- Computed Tomography Imaging of Non-Neoplastic and Neoplastic Benign Gastric Disease. [Review]
- CPCurr Probl Diagn Radiol 2018 Jan 11
- Gastric disease is a common finding in patients imaged in the emergency department, with radiologists encountering more and more benign gastric disease on CT. In this case based review, we discuss CT...
Gastric disease is a common finding in patients imaged in the emergency department, with radiologists encountering more and more benign gastric disease on CT. In this case based review, we discuss CT appearance of various benign gastric pathology including self-limiting conditions such as gastritis, different benign gastric neoplasms, as well as life threatening disorders such as perforation, obstruction, and hemorrhage.
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- Characterization of morphological conversions of Helicobacter pylori under anaerobic conditions. [Journal Article]
- MIMicrobiol Immunol 2018 Feb 15
- Helicobacter pylori (H. pylori) is a Gram-negative microaerophilic bacterial pathogen which colonizes the stomach of more than half the human population, and is linked to chronic gastritis, peptic ul...
Helicobacter pylori (H. pylori) is a Gram-negative microaerophilic bacterial pathogen which colonizes the stomach of more than half the human population, and is linked to chronic gastritis, peptic ulcers, and gastric cancer. Spiral-shaped H. pylori undergo morphologic conversion to the viable but not culturable (VBNC) coccoid form as they transit from the microaerobic stomach into the anaerobic intestinal tract. However, little is known about the morphological and pathogenic characteristics of H. pylori under prolonged anaerobic conditions. In this study, we used scanning electron microscopy to document the anaerobiosis-induced morphological change of H. pylori, from helical to coccoid to the newly defined fragmented form. Western blot analysis indicated that all three forms expressed certain pathogenic proteins, including the bacterial cytotoxin-associated gene A (CagA), components of the cag-Type IV secretion system (TFSS), the blood group antigen-binding adhesin BabA, and UreA (apoenzyme of urease) at nearly equivalent levels. Similar urease activities were also detected in each form of H. pylori. However, in contrast to the helical form, the anaerobiosis-induced coccoid and fragmented forms of H. pylori were abrogated for bacterial motility and TFSS activity. Notably, we demonstrated that some of the anaerobiosis-induced fragmented state cells could be converted to proliferation-competent helical bacteria in vitro. These results indicate that prolonged exposure to the anaerobic intestine might not eliminate the potential for H. pylori to recover into the helical pathogenic state.