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(Gastrointestinal bleeding lower)
5,831 results
  • Morphological and functional impairment in the gut in a partial body irradiation minipig model of GI-ARS. [Journal Article]
  • IJInt J Radiat Biol 2018 Nov 26; :1-52
  • Kaur A, Ten Have GAM, … Moroni M
  • CONCLUSIONS: This lower hemi-body irradiation model allowed for extended survival at GI-specific ARS doses and development of a well-controlled GI syndrome with minimal hematopoietic injury or confounding mortality from cardiopulmonary damage. A dose-dependent impairment in the intestinal structure resulted in overall decreased gut functionality followed by a partial recovery. However, while the structure appeared to be recovered, not all functionality was attained. PBI induced systemic inflammation and altered the IGF-1 hormone indicating that these can be used as biomarkers in the minipig even under partial body conditions. This PBI model aligns with other minipig models under BARDA's large animal consortium to test medical countermeasure efficacy against a less complex GI-specific ARS injury.
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