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(Gastrointestinal bleeding occult)
1,561 results
  • NSAIDs and the small bowel. [Journal Article]
  • COCurr Opin Gastroenterol 2018 Feb 12
  • Tai FWD, McAlindon ME
  • CONCLUSIONS: NSAID- related enteropathy is common and often presents subclinically. The most common presentation is anaemia, which may be less common in those on cyclo-oxygenase (COX)-2 inhibitors than nonselective NSAIDs. PPI use worsens NSAID enteropathy with more occult bleeding and ulceration and has been linked to gram-negative intestinal dysbiosis. If NSAID cessation is not possible, COX-2 inhibition without PPI therapy should be considered in patients with upper gastrointestinal risk factors. Mucoprotective agents such as misoprostol and rebamipide show promise and probiotics may have a future role.
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