- GEOGRAPHIC TONGUE THAT RESPONDS TO THE TREATMENT OF PREGABALIN: CAN IT BE A NEW TREATMENT CHOICE? [Letter]
- DTDermatol Ther 2018 Oct 26; :e12776
- Geographical tongue, also known as benign migratory glossitis or erythema migrans, is a benign dermatosis whose spesific etiology is not known due to the disappearance of central erythematous and fil...
Geographical tongue, also known as benign migratory glossitis or erythema migrans, is a benign dermatosis whose spesific etiology is not known due to the disappearance of central erythematous and filiform papillaries surrounded by a hyperkeratotic ring forming the geographical shape on the tongue. In treatment, topical corticosteroids may be recommended for symptomatic relief. Pregabalin is a drug with, GABA analog structure. Pregabalin is a drug used and investigated in epilepsy, neuropathic pain, anxiety, and sleep disorders. We reported in a patient with geographical tongue successfully treated with pregabalin. We believe that geographic tongue lesions that do not have an effective treatment option in the future may be a new and successful treatment option supported by pregabalin treated case series and prospective studies. This article is protected by copyright. All rights reserved.
- Pulmonary fungal granulomas and fibrinous pneumonia caused by different hypocrealean fungi in reptiles. [Journal Article]
- VMVet Microbiol 2018; 225:58-63
- In contrast to fungal dermatitis, fungal glossitis and disseminated visceral mycosis, fungal infection of the lung has so far rarely been described in reptiles. Pulmonary fungal granulomas were diagn...
In contrast to fungal dermatitis, fungal glossitis and disseminated visceral mycosis, fungal infection of the lung has so far rarely been described in reptiles. Pulmonary fungal granulomas were diagnosed histopathologically within the scope of post mortem examinations. Fragments of the 18S-internal transcribed spacer1-5.8S rDNA (SSU-ITS1-5.8S) and 28S rDNA (LSU), including domains (D)1 and D2 as well as the protein coding gene translation elongation factor 1 alpha (TEF) were used for phylogenetical analysis after isolation of the fungal pathogen by culturing. Ten reptiles, including lizards (n = 6), snakes (n = 1), crocodilians (n = 2) and tortoises (n = 1) presented with pulmonary fungal granulomas (n = 8) and fibrinous pneumonia (n = 2) caused by different non-clavicipitaceous and clavicipitaceous species of the order Hypocreales. Purpureocillium lavendulum (n = 2) and Metarhizium robertsii (n = 1) as the etiologic agents of pneumonia in reptile species are described for the first time. Fungal pulmonary granulomas caused by clavicipitaceous fungi (n = 6) were all associated with disseminated visceral mycosis as well as oral fungal granulomas (n = 4) and/or fungal dermatitis (n = 1). Differing infection routes being likely for clavicipitaceous and non-clavicipitaceous fungal pathogens. A potential zoonotic health risk should be taken into account during necropsy or lung sampling in live reptiles with pulmonary fungal granulomas, since human infections, mainly keratitis and sclerokeratitis, caused by Beauveria bassiana, Metarhizium robertsii and Purpureocillium lilacinum, have occasionally been described.
- [Oral allergies]. [Journal Article]
- RMRev Med Brux 2018; 39(4):317-321
- Oral allergies to dental materials are a growing problem and remain poorly diagnosed by health professionals. The complaints of patients with oral allergy are various and include sensations of burnin...
Oral allergies to dental materials are a growing problem and remain poorly diagnosed by health professionals. The complaints of patients with oral allergy are various and include sensations of burning or stinging of the oral mucosa, sensations of dryness of the oral cavity, or general symptoms such as headache, dyspepsia, asthenia, arthralgia, and myalgia. Signs suggestive of oral allergy include erythema, edema, purpuric patches on the palate, ulcerations of the oral mucosa (canker sore), gingivitis, glossitis mimicking geographic tongue, angular cheilitis, peri-oral eczema or the presence of lichenoid reactions of the oral mucosa. The diagnosis of an allergy will include data from the anamnesis, the clinical examination, as well as the results of allergy tests: epicutaneous tests (patch tests) or cutaneous tests (prick tests), possibly completed by a blood test ( in vitro lymphoblastic transformation test ou LTT).
- Dermatologic findings of vitamin B12 deficiency in infants. [Journal Article]
- PDPediatr Dermatol 2018; 35(6):796-799
- CONCLUSIONS: Cutaneous findings are a common feature of vitamin B12 deficiency in Indian infants and resolve with treatment.
- Oral mucositis associated with anti-EGFR therapy in colorectal cancer: single institutional retrospective cohort study. [Journal Article]
- BCBMC Cancer 2018 Oct 05; 18(1):957
- CONCLUSIONS: Pmab-based chemotherapy resulted in significantly higher grades of oral mucositis compared with Cmab-based chemotherapy. The oral condition should be monitored carefully and early supportive care should be provided for patients treated with Pmab-based chemotherapy.
- Anemia in Pregnancy Presenting as Acute Glossitis. [Journal Article]
- JOJ Obstet Gynaecol Can 2018 Sep 21
- Characteristics of lingual papillae in diabetic rats. [Journal Article]
- MMorphologie 2018 Sep 12
- Diabetes mellitus (DM) is a metabolic disorder resulting with many different complications including soft tissue abnormalities in the oral cavity such as periodontitis and salivary and taste dysfunct...
Diabetes mellitus (DM) is a metabolic disorder resulting with many different complications including soft tissue abnormalities in the oral cavity such as periodontitis and salivary and taste dysfunction. Previous studies also reported fungal and bacterial infections in oral cavity in these patients. This study aims to represent three dimentional morphologic ultrastructural changes of the diabetic rat tongue via scanning electron microscopy. Twenty-four (24) adult male Spraque-Dawley rats, (weight ranging between 200-250g) included in the study were randomly assigned into two groups: control rats were injected with intraperitoneally saline alone, experimental diabetes group received streptozotocin (STZ) (80mg/kg) administrated intraperitoneally. On month four, by the end of experimental period, all animals of each group were anesthetised. All tongues were dissected totally, postfixed in 2% osmium tetroxide and then dried by critical point drying before SEM analysis. Finally, superficial epithelial configurations of the lingual papillae in experimental diabetic rats were examined by scanning electron microscopy. Diabetes mellitus caused thickness, hyperceratosis and different epithelial changes, We observed yeast-like structures and bacterial colonisations on the papillar and epithelial structure of the tongue. The morphological atrophic changes of lingual mucosa and the median rhomboid glossitis (which is primary finding of candidal infection) are characteristic observations on the lingual mucosa of the streptozotocin treated rats.
- Particular shape of the tongue and benign migratory glossitis. [Case Reports]
- PAPan Afr Med J 2018; 30:11
- StatPearls [BOOK]
- BOOKStatPearls Publishing: Treasure Island (FL)
- Glucagonomas are neuroendocrine tumors of the pancreatic islets that secrete glucagon. Glucagonoma syndrome occurs due to the effects of elevated glucagon levels secreted by the tumor. The first case...
Glucagonomas are neuroendocrine tumors of the pancreatic islets that secrete glucagon. Glucagonoma syndrome occurs due to the effects of elevated glucagon levels secreted by the tumor. The first case was described in 1942 by Becker et al. in a 45-year-old woman presenting with widespread dermatitis, weight loss, glossitis, and abnormal glucose tolerance associated with an islet cell neoplasm of the pancreas on autopsy specimen. IN 1966, McGavran and colleagues identified the classic symptoms of mild diabetes and dermatitis along with elevated glucagon levels related to a metastatic alpha cell tumor of the pancreatic islets. This review highlights the clinical presentation and management of glucagonomas.
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- [Clinical analysis for oral mucosal disease in 21 972 cases]. [Journal Article]
- ZNZhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jul 28; 43(7):779-783
- To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment. Methods: The clinical data for all patients, who were treated...
To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment. Methods: The clinical data for all patients, who were treated in Xiangya Hospital of Central South University from April 2013 to March 2017, were collected. After screening, weighing and classifying, sex and age distribution for the disease was analyzed. Results: The female with the age between 40 to 49 were in the majority among 21 972 patients. The ratio between men to women was 1:1.05. According to the classification of diseases, the most common diseases were as follows: recurrent aphthous ulcer (27.17%), burning mouth syndrome (15.72%), oral submucous fibrosis (14.75%), oral lichen planus (10.38%), oral leukoplakia (4.21%), traumatic ulceration (4.14%), chronic cheilitis (3.47%), oral fungal infection (3.26%), and atrophic glossitis (2.74%). Recurrent oral ulcer (28.65%), burning mouth syndrome (23.70%) and oral lichen planus (13.31%) were the most common 3 kinds of oral mucosal diseases during females in Hunan. Oral submucous fibrosis was the most common oral mucosal disease among males in Hunan (28.56%). Conclusion: Recurrent oral ulcer, burning mouth syndrome and oral lichen planus are very popular in women in Hunan Province, and oral submucous fibrosis is the most common disease in male in this region. It shows a high trend of incidence in the surrounding provinces.