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77,750 results
  • A NIR probe tracks and treats lung tumor initiating cells by targeting HMOX2. [Journal Article]
    J Am Chem Soc 2019Kim JJ, Lee YA, … Chang YT
  • Tumor initiating cells (TIC) are resistant to conventional anti-cancer therapy and associated with metastasis and relapse in cancer. Although various TIC markers and their antibodies have been proposed, it is limited to use of antibodies for in vivo imaging or treatment of TIC. In this study, we discovered heme oxygenase 2 (HMOX2) as a novel biomarker for TIC and developed a selective small molec…
  • Update on Preoperative Embolization of Bone Metastases. [Review]
    Semin Intervent Radiol 2019; 36(3):241-248Ma J, Tullius T, Van Ha TG
  • Management of patients with bone metastasis is complex and should include different specialties. Goals of therapy should be identified for each individual patient prior to the start of treatment. Preoperative embolization has generally been considered a safe and effective means of reducing intraoperative blood loss with recent studies and advances in technique reported. Update on indications, con…
  • Ionic-surfactant-mediated electro-dewetting for digital microfluidics. [Journal Article]
    Nature 2019; 572(7770):507-510Li J, Ha NS, … 'cj' Kim CJ
  • The ability to manipulate droplets on a substrate using electric signals1-known as digital microfluidics-is used in optical2,3, biomedical4,5, thermal6 and electronic7 applications and has led to commercially available liquid lenses8 and diagnostics kits9,10. Such electrical actuation is mainly achieved by electrowetting, with droplets attracted towards and spreading on a conductive substrate in …
  • Structural basis for lamin assembly at the molecular level. [Journal Article]
    Nat Commun 2019; 10(1):3757Ahn J, Jo I, … Ha NC
  • Nuclear structure and function are governed by lamins, which are intermediate filaments that mostly consist of α-helices. Different lamin assembly models have been proposed based on low resolution and fragmented structures. However, their assembly mechanisms are still poorly understood at the molecular level. Here, we present the crystal structure of a long human lamin fragment at 3.2 Å resolutio…
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