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9,548 results
  • Post-Translational Modifications in NETosis and NETs-Mediated Diseases. [Review]
    Biomolecules 2019; 9(8)Hamam HJ, Palaniyar N
  • : Neutrophils undergo a unique form of cell death that generates neutrophil extracellular traps (NETs) that may help to neutralize invading pathogens and restore homeostasis. However, uncontrolled NET formation (NETosis) can result in numerous diseases that adversely affect health. Recent studies further elucidate the mechanistic details of the different forms of NETosis and their common end stru…
  • Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug. [Journal Article]
    Invest New Drugs 2019Chen J, Luo B, … Pi R
  • Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system (CNS). Effective treatments remain limited. Therefore, novel chemotherapy drugs with high efficiency and few adverse effects are urgently needed. Histone deacetylase (HDAC) and serum and glucocorticoid-regulated protein kinase 1 (SGK1) are targets for the prevention and treatment of GBM. Rhein has antit…
  • Small molecule HDAC inhibitors: Promising agents for breast cancer treatment. [Review]
    Bioorg Chem 2019; 91:103184Huang M, Zhang J, … Ling R
  • Breast cancer, a heterogeneous disease, is the most frequently diagnosed cancer and the second leading cause of cancer-related death among women worldwide. Recently, epigenetic abnormalities have emerged as an important hallmark of cancer development and progression. Given that histone deacetylases (HDACs) are crucial to chromatin remodeling and epigenetics, their inhibitors have become promising…
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