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407,407 results
  • Monkeypox: a review of the 2022 outbreak. [Journal Article]
    Br Med Bull. 2023 Feb 06 [Online ahead of print]Lim EY, Whitehorn J, Rivett L
  • CONCLUSIONS: The higher numbers of HIV-positive patients in the current outbreak has allowed better description of the disease in patients co-infected with HIV and monkeypox. The absence of more severe symptoms in HIV-positive patients in the current outbreak could possibly be due to the fact that most of these patients had well-controlled HIV, although further characterization of this cohort of patients would be useful.Current treatment and vaccination options have been extrapolated from studies of other Orthopox viruses. There remains a need for more data on the safety and efficacy of these options in the context of monkeypox infections.
  • The cytological diagnosis of Pneumocystis jiroveci pneumonia in bronchoalveolar lavage. [Journal Article]
    Cytojournal. 2023; 20:2.Kapatia G, Saikia A, … Dey P
  • CONCLUSIONS: BAL cytology is one of the important modes of investigations which can detect PJP infection. The history of fever, cough, immunosuppression, bilateral haziness in the radiography of lung and the characteristic alveolar cast indicate the possibility of PJP infection. Cytology can provide early diagnosis and can reduce the mortality of immunocompromised patients.
  • Late-onset efavirenz toxicity: A descriptive study from Pretoria, South Africa. [Journal Article]
    South Afr J HIV Med. 2023; 24(1):1439.Munsami L, Schutte CM, … Hiesgen J
  • CONCLUSIONS: Late-onset efavirenz toxicity typically presented with ataxia and encephalopathy, but psychosis can be the presenting feature. The outcome after withdrawal was good, but the mortality of 10.0% is concerning. Recent changes in guidelines favour dolutegravir, but many patients remain on efavirenz, and awareness of the condition is vital.
  • A Case of Pericardial Effusion and Human Immunodeficiency Virus in the Postmodern Era. [Case Reports]
    Cureus. 2023 Jan; 15(1):e33349.Silverio Lopez R, Agrawal P
  • Pericardial effusion is a relatively common cardiac pathology associated with various infectious and non-infectious etiologies. In developed countries, viral pericarditis and idiopathic reasons are the two most common causes of this condition. Mycobacterium tuberculosis is prevalent in developing countries and is the most common cause of pericardial effusion in these regions. Parasitic and bacter…
  • Investigational drugs for HIV: trends, opportunities and key players. [Journal Article]
    Expert Opin Investig Drugs. 2023 Feb 07 [Online ahead of print]Overmars RJ, Krullaars Z, Mesplède T
  • Since the first antiretroviral drug was described, the field of HIV treatment and prevention has undergone two drug-based revolutions: the first one, enabled by the virtually concomitant discovery of non-nucleoside reverse transcriptase and protease inhibitors, was the inception of combined antiretroviral therapy. The second followed the creation of integrase strand-transfer inhibitors with impro…
  • Project T-SHARP: study protocol for a multi-site randomized controlled trial of tele-harm reduction for people with HIV who inject drugs. [Journal Article]
    Trials. 2023 Feb 07; 24(1):96.Tookes HE, Oxner A, … Bartholomew TS
  • CONCLUSIONS: The T-SHARP Trial will be the first to our knowledge to test the efficacy of an innovative telehealth intervention with PWID with uncontrolled HIV delivered via an SSP to support HIV viral suppression. Tele-Harm Reduction is further facilitated by a peer to support adherence and bridge the digital divide. This innovative, flipped healthcare model sets aside the traditional healthcare system, reduces multi-level barriers to care, and meets PWID where they are. The T-SHARP trial is a pragmatic clinical trial that seeks to transform the way that PWID access HIV care and improve HIV clinical outcomes.
  • Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases. [Review]
    Infect Agent Cancer. 2023 Feb 07; 18(1):7.Gottschalk CG, Peterson D, … Roy A
  • Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze human civilization's economy and social growth, leaving an enduring damage that will take an exceptionally long time to repair. While a majority of infected patients survive after mild …
  • Potential role of doravirine for the treatment of HIV-1-infected persons with transmitted drug resistance. [Journal Article]
    AIDS Res Ther. 2023 Feb 07; 20(1):8.Rhee SY, Schapiro JM, … Shafer RW
  • CONCLUSIONS: First-line therapy containing doravirine plus two NRTIs is expected to be effective in treating most persons with TDR as more than 80% of TDR sequences had a single NNRTI DRM and as more than 90% with a single DRM were expected to be susceptible to doravirine. However, caution is required for the use of doravirine in persons with more than one NNRTI DRM even if none of the DRMs are canonical doravirine-resistance mutations.
  • Student nurses' perceptions and experiences in caring for people living with HIV/AIDS: a qualitative study. [Journal Article]
    BMC Med Educ. 2023 Feb 07; 23(1):99.Shi C, Cleofas JV
  • CONCLUSIONS: Findings shed light on the development and changes in student nurses' perspectives on PLWHAs throughout their clinical experiences. Student nurses' perceptions and attitudes toward PLWHAs progressed through three distinct stages, and positive changes were observed after care-giving. Participants' perceptions and practical experiences with patients with AIDS enable patients to receive fair and high-quality care and provide valuable insights for nursing educators better prepare HIV nurses.
  • New designs for HIV-1 integrase inhibitors: a patent review (2018-present). [Journal Article]
    Expert Opin Ther Pat. 2023 Feb 07 [Online ahead of print]Taoda Y, Sugiyama S, Seki T
  • Combination antiretroviral therapy (cART) has dramatically reduced morbidity and mortality of HIV-1-infected patients. Integrase strand transfer inhibitors (INSTIs) play an important role as a key drug in cART. The second-generation INSTIs are very potent, but due to the emergence of highly resistant viruses and the demand for more conveniently usable drugs, the development of "third-generation" …
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