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29,177 results
  • Water networks can determine the affinity of ligand binding to proteins. [Journal Article]
    J Am Chem Soc 2019Darby JF, Hopkins AP, … Fischer M
  • Solvent organization is a key but underexploited contributor to the thermodynamics of protein-ligand recognition, with implications for ligand discovery, drug resistance and protein engineering. Here, we explore the contribution of solvent to ligand binding in the Haemophilus influenzae virulence protein SiaP. By introducing a single mutation without direct ligand contacts, we observed a >1000-fo…
  • The Gut Microbiota in Multiple Sclerosis: An Overview of Clinical Trials. [Journal Article]
    Cell Transplant 2019; :963689719873890Schepici G, Silvestro S, … Mazzon E
  • Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, and degenerative disease that affects the central nervous system. A recent study showed that interaction between the immune system and the gut microbiota plays a crucial role in the development of MS. This review reports the clinical studies carried out in recent years that aimed to evaluate the composition of the microbiota in pa…
  • Degraded neutrophil extracellular traps promote the growth of Actinobacillus pleuropneumoniae. [Journal Article]
    Cell Death Dis 2019; 10(9):657de Buhr N, Bonilla MC, … von Köckritz-Blickwede M
  • Actinobacillus pleuropneumoniae (A.pp) causes severe pneumonia associated with enormous economic loss in pigs. Peracute diseased pigs die in <24 h with pneumonia. Neutrophils are the prominent innate immune cell in this infection that massively infiltrate the infected lung. Here we show that neutrophils release neutrophil extracellular traps (NETs) as response to A.pp infection. Numerous NET-mark…
  • Clonal diversity of Haemophilus influenzae carriage isolated from under the age of 6 years children. [Journal Article]
    BMC Res Notes 2019; 12(1):565Shooraj F, Mirzaei B, … Hosseini F
  • Pharyngeal carriers such as H. influenzae seem to constitute the only reservoir and probably the only transmission vehicle of the invasive disease. The aims of this study were to estimate the prevalence of H. influenzae carriage, to characterize antibiotic susceptibility, and to explore genetic diversity of H. influenzae isolates. Sampling was carried out as nasopharynx swabs among children less …
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