- Cytogenetic Biomonitoring of Dental Technicians: A Cross-Sectional Study. [Journal Article]
- JPJ Prosthodont 2018 Dec 07
- CONCLUSIONS: Cytogenetic biomarkers in dental technician buccal mucosa are increased compared with control groups. This increase may be associated with more extensive exposure to potentially harmful components of the materials used in everyday dental practice. This article is protected by copyright. All rights reserved.
- Spectral analysis of the EBT3 radiochromic films for clinical photon and electron beams. [Journal Article]
- MPMed Phys 2018 Dec 08
- CONCLUSIONS: The spectral shape of the EBT3 radiochromic films irradiated with photons (including FFF) and electron beams is beam quality and dose rate independent; however it varies with dose level, batch, and spectroscopy system used. This article is protected by copyright. All rights reserved.
- Contrast-Enhanced Ultrasound for identifying circulatory complications after liver transplants in children. [Journal Article]
- PTPediatr Transplant 2018 Dec 07; :e13327
- Our main goal with this study was to share our off-label experience with CEUS for identifying circulatory complications after liver transplantation in children. A total of 74 CEUS examinations perfor...
Our main goal with this study was to share our off-label experience with CEUS for identifying circulatory complications after liver transplantation in children. A total of 74 CEUS examinations performed on 34 pediatric patients who underwent a liver transplant were retrospectively included. About 53% of the examinations were performed on children 2 years old or younger. About 82% of the examinations were performed within 30 days from the transplant. About 62% of patients were transplanted due to a cholestatic disease, 11% due to a metabolic disease, 8% were re-transplanted due to graft failure, and 19% was due to other conditions. BA was the most common reason for transplantation and represented 38% of patients. About 38% of the transplantations were performed with whole grafts from DD, 40% with split liver grafts, and 22% with left lateral segments from LD. For diagnosing arterial circulatory complications, the PPV was 80%. For diagnosing portal vein circulatory complications, the PPV was 66.7%. NPV was 100%. In 28% of the examinations, the examiner could not visualize the normal arterial blood flow without CEUS. CEUS is a non-invasive and safe imaging technique that seems valuable in these patients and further efforts are needed to license its use in the post-transplant setting.
- Dysglycemia among youth with type 1 diabetes and suboptimal glycemic control in The Flexible Lifestyle Empowering Change (FLEX) trial. [Journal Article]
- PDPediatr Diabetes 2018 Dec 10
- CONCLUSIONS: Almost 80% of adolescents with elevated HbA1c had an episode of clinical hypoglycemia and >50% had clinically serious hypoglycemia in a week. Increased education alongside access to emerging diabetes technologies may help to prevent hypoglycemia while improving glycemic control. This article is protected by copyright. All rights reserved.
- Divergent evolution in the genomes of closely-related lacertids, Lacerta viridis and L. bilineata and implications for speciation. [Journal Article]
- GGigascience 2018 Dec 10
- CONCLUSIONS: The combination of short and long sequence reads resulted in one of the most complete lizard genome assemblies. The characterization of a diverse array of genomic features provided valuable insights into the demographic history of divergence among European green lizards, as well as key species differences, some of which are candidates that could have played a role in speciation. In addition, our study generated valuable genomic resources that can be used to address conservation related issue in lacertids.
- A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection. [Journal Article]
- IIInt Immunol 2018 Dec 07
- The development of a universal influenza vaccine that can provide a robust and long-lasting protection against a broader range of influenza virus strains is a global public health priority. One appro...
The development of a universal influenza vaccine that can provide a robust and long-lasting protection against a broader range of influenza virus strains is a global public health priority. One approach to improve vaccine efficacy is to use an adjuvant to boost immune responses to the target antigens; nevertheless, the role of adjuvants in the context of influenza vaccines is not fully understood. We have previously developed the K3-schizophyllan (SPG) adjuvant, which is composed of nanoparticulated oligodeoxynucleotides K3, a TLR9 agonist, with SPG, a non-agonistic β-glucan ligand of Dectin-1. In this study, K3-SPG given with conventional influenza hemagglutinin (HA) split vaccine (K3-SPG HA) conferred protection against antigenically mismatched heterologous virus challenge. While K3-SPG HA elicited robust cross-reactive HA-specific IgG2c and CD8 T-cell responses, CD8 T-cell depletion had no impact on this cross-protection. In contrast, K3-SPG HA was not able to confer protection against heterologous virus challenge in FcRγ-deficient mice. Our results indicated that FcγR-mediated antibody responses induced by the HA antigen and K3-SPG adjuvant were important for potent protection against antigenically mismatched influenza virus infection. Thus, we demonstrated that the K3-SPG-adjuvanted vaccine strategy broadens protective immunity against influenza and provides a basis for the development of next-generation influenza vaccines.
- A Preliminary Clinical Trial Comparing Split Treatments to the Face and Hand With Autologous Fat Grafting and Platelet-Rich Plasma (PRP): A 3D, IRB-Approved Study. [Journal Article]
- ASAesthet Surg J 2018 Dec 10
- CONCLUSIONS: Autologous fat grafting continues to be a safe and effective adjunct in facial and hand aesthetic surgery. This study will require more patients and longer follow-up periods to determine whether PRP has a potential role to increase fat graft retention in aesthetic patients.
- Optical properties of pyridine adsorbed polycyclic aromatic hydrocarbons using quantum chemical calculations. [Journal Article]
- PCPhys Chem Chem Phys 2018 Dec 10
- Polycyclic aromatic hydrocarbons (PAHs), the molecular version of graphene, having edges saturated with hydrogen atoms, have recently emerged as a novel nanoplasmonic material. In this work, we inves...
Polycyclic aromatic hydrocarbons (PAHs), the molecular version of graphene, having edges saturated with hydrogen atoms, have recently emerged as a novel nanoplasmonic material. In this work, we investigate the optical properties of pristine and pyridine adsorbed circular and triangular PAHs. We base our calculations on computationally efficient first-principles time-dependent density-functional theory (TD-DFT) calculations. We find substantial changes in the optical absorption spectra induced by the presence of the pyridine molecule. In addition, with the help of electron difference density (EDD) maps, we demonstrate a strong optical interaction between PAHs and pyridine molecules. The main effect of pyridine adsorption is to split the plasmon band and to redistribute the optical absorption in a wider energy range. We believe that our findings can help in the design of novel plasmonic devices having PAHs as basic building blocks.
- The importance of pancreatic inflammation in endosonographic diagnostics of solid pancreatic masses. [Journal Article]
- MUMed Ultrason 2018 Dec 08; 20(4):427-435
- CONCLUSIONS: Pancreatic inflammation (either focal or involving the whole gland) lowers the diagnostic sensibility of EUS in the work- up of pancreatic masses suspected for cancer, requiring further invasive diagnostic methods. Focal autoimmune pancreatitis and paraduodenal pancreatitis are still confused with pancreatic cancer, even in the absence of pancreatic inflammation.
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- Medication belief as correlate of medication adherence among patients with diabetes in Edo State, Nigeria. [Journal Article]
- NONurs Open 2019; 6(1):197-202
- The study aim was to determine the level of medication adherence, patient medication belief and to determine the correlation between medication belief and medication adherence among patients with dia...
The study aim was to determine the level of medication adherence, patient medication belief and to determine the correlation between medication belief and medication adherence among patients with diabetes. This is to find out whether medication belief of patient could enhance medication adherence which in turn would promote effective management of diabetic mellitus in Nigeria.