- StatPearls [BOOK]
- BOOKStatPearls Publishing: Treasure Island (FL)
- Famotidine decreases the production of stomach acid, and its pharmacologic activity is used in the treatment of acid-related gastrointestinal conditions. Famotidine is available both by prescri...
Famotidine decreases the production of stomach acid, and its pharmacologic activity is used in the treatment of acid-related gastrointestinal conditions. Famotidine is available both by prescription and over-the-counter (OTC). It is US Food and Drug Administration (FDA) approved and available through prescription for the treatment of duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD) in adults and children, with a further indication for treatment of pathological hypersecretory conditions in adults. Famotidine is also FDA approved for over-the-counter treatment and prevention of heartburn due to gastroesophageal reflux in adults and pediatrics. Famotidine is used off-label for reducing gastrointestinal risks of NSAIDs. It is also used off-label for the treatment of refractory urticarial, prevention of stress ulcer in critically-ill patients and symptomatic relief of gastritis.
- Facteurs en cause et formes cliniques du reflux gastro-oesophagien chez l’adulte. Une prévalence élevée qui augmente avec l’âge. [Journal Article]
- RPRev Prat 2016; 66(10):1080-1083
- Factors and clinical forms of gastroesophageal reflux disease in adults. Gastro-oesophageal reflux (GERD) is a common complaint. Factors involved in GERD are the antireflux barrier dysfunction, the o...
Factors and clinical forms of gastroesophageal reflux disease in adults. Gastro-oesophageal reflux (GERD) is a common complaint. Factors involved in GERD are the antireflux barrier dysfunction, the oesophageal sensitivity disorders, impaired oesophageal clearance, the acid component of the refluxate, and impaired gastric emptying. Risk factors for GERD are hiatal hernia and obesity. Although heartburn or regurgitations are specific to characterize GERD, patients usually report a number of associated symptoms such as cough, eructation, globus, hiccups, chest pain, and sleep disturbances. Complications of GERD are oesophagitis, gastrointestinal haemorrhage, peptic stricture or Barrett's oesophagus.
- Nocturnal gastroesophageal reflux increases the risk of daytime sleepiness in women. [Journal Article]
- SMSleep Med 2018 Oct 13; 53:94-100
- CONCLUSIONS: Women with nGER were at increased risk of developing daytime sleepiness and snoring augmented this association. In addition, women with both nGER and snoring were also at increased risk of developing involuntary falling asleep.
- Long-term efficacy of laparoscopic Nissen versus Toupet fundoplication for the management of types III and IV hiatal hernias. [Journal Article]
- SESurg Endosc 2018 Nov 26
- CONCLUSIONS: Patient-reported symptoms and satisfaction did not vary for patients receiving laparoscopic Nissen versus Toupet fundoplication, which may indicate that patients with large type III and IV hiatal hernia undergoing either procedure have similar long-term postoperative symptom control.
- Gastric band migration to gastrointestinal lumen and possibilities of its surgical treatment. [Journal Article]
- ACAdv Clin Exp Med 2018 Nov 23
- CONCLUSIONS: Surgical or endoscopic treatment in patients with a migrated band is an individual matter depending on the type and size of band dislocation, its clinical symptoms and the general state of the patient, but also on the experience of the operating team and the quality of the equipment.
- Eosinophilic Esophagitis. [Review]
- MCMed Clin North Am 2019; 103(1):29-42
- Eosinophilic esophagitis (EoE) is a chronic disorder characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. EoE represents an important caus...
Eosinophilic esophagitis (EoE) is a chronic disorder characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. EoE represents an important cause of upper gastrointestinal morbidity. Primary care providers are pivotal for timely and accurate recognition of symptoms of eosinophilic esophagitis, for facilitating diagnoses through specialist referrals, and for understanding management strategies. This process begins with a thorough understanding of the clinical features of EoE, its associated atopic conditions, and its evolving epidemiology.
- Acute milk-alkali syndrome [Journal Article]
- EDEndocrinol Diabetes Metab Case Rep 2018 Oct 31; 2018(1)
- A 74-year-old woman presented with progressive lethargy, confusion, poor appetite and abdominal pain. She was found to have non-PTH-mediated severe hypercalcemia with renal failure and metabolic alka...
A 74-year-old woman presented with progressive lethargy, confusion, poor appetite and abdominal pain. She was found to have non-PTH-mediated severe hypercalcemia with renal failure and metabolic alkalosis. Extensive workup for hypercalcemia to rule out alternate etiology was unrevealing. Upon further questioning, she was taking excess calcium carbonate (Tums) for her worsening heartburn. She was diagnosed with milk-alkali syndrome (MAS). Her hypercalcemia and alkalosis recovered completely with aggressive hydration along with improvement in her renal function. High index of suspicion should be maintained and history of drug and supplements, especially calcium ingestion, should be routinely asked in patients presenting with hypercalcemia to timely diagnose MAS and prevent unnecessary tests and treatments.
- On-demand versus half-dose continuous therapy with esomeprazole for maintenance treatment of gastroesophageal reflux disease: A randomized comparative study. [Randomized Controlled Trial]
- MMedicine (Baltimore) 2018; 97(43):e12732
- CONCLUSIONS: Intensities and frequencies of heartburn and regurgitation responded well to maintenance treatment in patients in the on-demand and continuous groups. On-demand therapy with esomeprazole 40 mg appears to be sufficient for maintenance treatment in GERD patients.
- Dual Delayed-Release Dexlansoprazole for Healing and Maintenance of Healed Erosive Esophagitis: A Safety Study in Adolescents. [Journal Article]
- DDDig Dis Sci 2018 Nov 02
- CONCLUSIONS: Dexlansoprazole is safe and efficacious for healing EE and maintenance of healed EE in adolescents.
New Search Next
- Gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome: common overlapping gastrointestinal disorders. [Review]
- AGAnn Gastroenterol 2018 Nov-Dec; 31(6):639-648
- Several studies have indicated an overlap between gastroesophageal reflux disease (GERD) and various functional gastrointestinal disorders (FGIDs). The overlapping conditions reported have mainly bee...
Several studies have indicated an overlap between gastroesophageal reflux disease (GERD) and various functional gastrointestinal disorders (FGIDs). The overlapping conditions reported have mainly been functional dyspepsia (FD) and irritable bowel syndrome (IBS). The available literature is frequently based on symptomatic questionnaires or endoscopic procedures to diagnose GERD. Rarely, among patients with heartburn, pathophysiological evaluations have been considered to differentiate those with proven GERD from those without. Moreover, both GERD and IBS or FD showed enormous heterogeneity in terms of the criteria and diagnostic procedures used. The GERD-IBS overlap ranges from 3-79% in questionnaire-based studies and from 10-74% when GERD has been diagnosed endoscopically. The prevalence of functional dyspepsia (after normal upper endoscopy) is 12-15% and an overlap with GERD has been reported frequently. Only a few studies have considered a potential overlap between functional heartburn (FH) and IBS using a 24-h pH-metry or impedance-pH evaluation. Similar data has been reported for an overlap between FH and FD. Recently, a revision of the Rome criteria for esophageal FGIDs identified both FH and hypersensitive esophagus (HE) as potential functional esophageal disorders. This might increase the potential overlap between different FGIDs, with FH and HE rather than with GERD. The aim of the present review article was to appraise and discuss the current evidence supporting the possible concomitance of GERD with IBS and FD in the same patients and to evaluate how various GERD treatments could impact on the quality of life of these patients.