- Spectrum-effect relationships between high-performance liquid chromatography fingerprints and anti-inflammatory activities of Leontopodium leontopodioides (Willd.) Beauv. [Journal Article]
- JCJ Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 06; 1104:11-17
- Leontopodium leontopodioides (Willd.) Beauv. is used therapeutically to prevent numerous diseases. Historically, L. leontopodioides extracts have been used to treat influenza infections, bronchitis, ...
Leontopodium leontopodioides (Willd.) Beauv. is used therapeutically to prevent numerous diseases. Historically, L. leontopodioides extracts have been used to treat influenza infections, bronchitis, acute and chronic nephritis, proteinuria, hematuria, and diabetes. However, the bioactive compounds that are responsible for the associated therapeutic effects have not yet been characterized. In this study, high-performance liquid chromatography was utilized to study the anti-inflammatory properties of L. leontopodioides through analysis of spectrum-effect relationships. The bioactive compounds that correlated with anti-inflammatory activities were partially identified. Following aqueous extraction, a variety of different polar organic solvents including petrol ether extracts, ethyl acetate extracts, n-butanol extracts, and residual aqueous extracts were successfully isolated from L. leontopodioides. These extracts were analyzed using high-performance liquid chromatography to generate HPLC fingerprints. A total of 32 common peaks were selected following a similarity analysis (SA). The spectrum-effect relationship was subsequently studied and inflammatory factors were identified following acute inflammatory experiments. The results revealed that the main peaks associated with anti-inflammatory activities were x1, x3, x4, x13, x14, x16 for interleukin-1 (IL-1), x5, x8, x9, x18, x26, x27, x30, x31, x32 for interleukin-6 (IL-6), and x28 and x29 for leukotriene B4 (LTB4). Following analysis of HPLC data, peaks x9 and x14 were identified as chlorogenic acid and ferulic acid, respectively. The current study utilized HPLC and pharmacological analyses to formulate a spectrum-effect relationship and identify bioactive compounds in L. leontopodioides.
- Urinary Biomarkers in the Evaluation of Primary Hematuria: A Systematic Review and Meta-Analysis. [Review]
- BCBladder Cancer 2018 Oct 29; 4(4):353-363
- CONCLUSIONS: The current diagnostic performance of biomarkers are inadequate to replace cystoscopy in the primary hematuria setting. However, AssureMDx in particular may have a role as a triage test for cystoscopy but further prospective data is required to validate these findings. Given the current evidence, the use of these markers as an adjunct to cystoscopy for the evaluation of hematuria should be considered investigational.
- Clinico-pathological characteristics and outcome of upper urinary tract urothelial carcinoma presenting to a tertiary care urology unit in Sri Lanka [Journal Article]
- CMCeylon Med J 2018 Sep 30; 63(3):129-132
- CONCLUSIONS: A relatively higher number females and high number of ureteric tumours were noted compared to similar studies from Asia.
- Diagnostic pathway efficacy for urinary tract cancer: population-based outcome of standardized evaluation for macroscopic haematuria. [Journal Article]
- SJScand J Urol 2018 Nov 09; :1-7
- CONCLUSIONS: Macroscopic haematuria had a cancer capture rate of 19%, with higher predictive values in men and at older age, whereas anticoagulant therapy did not influence the diagnostic yield. The demonstrated lack of effect on time to treatment underscores the need to consider the entire patient process when initiating healthcare reforms to improve outcome.
- Rhabdomyolysis during myelosuppression in a patient with central nervous system leukemia: A case report. [Journal Article]
- MMedicine (Baltimore) 2018; 97(45):e13091
- CONCLUSIONS: Rhabdomyolysis may occur after chemotherapy of leukemia. When patients developed hematuria, muscle weakness, or even asymptomatic elevation of CK levels, physicians should pay attention to the occurrence of rhabdomyolysis and take active hydration treatment.
- T cells in IgA nephropathy: role in pathogenesis, clinical significance and potential therapeutic target. [Journal Article]
- CEClin Exp Nephrol 2018 Nov 07
- CONCLUSIONS: T cells play an important role in IgAN pathogenesis and are correlated with its clinical severity. Clinical trials with the drugs targeting the reported alterations of the T-cell compartment are highly desirable.
- The mysterious gross haematuria in patient on Leflunomide: A case report and literature review. [Journal Article]
- UCUrol Case Rep 2019; 22:44-46
- Spectrum of Diseases/conditions Exhibiting Hemostatic Abnormalities in Patients Admitted to a Medical Intensive Care Unit of a Tertiary Care Hospital. [Journal Article]
- IJIndian J Crit Care Med 2018; 22(10):711-717
- CONCLUSIONS: Tropical diseases formed the majority of admissions with bleeding manifestations. Thrombocytopenia is an important marker to predict mortality and also has a significant association with MICU stay. APACHE II score was found to be a good predictor of blood transfusion requirements.
- Bioptically Proven "Anticoagulation-Related Nephropathy" Induced by Dual Antiplatelet Therapy. [Journal Article]
- CRCase Rep Nephrol Dial 2018 Sep-Dec; 8(3):216-222
- Anticoagulation-related nephropathy (ARN) is a significant and underdiagnosed complication in patients who receive anticoagulation therapy. It is characterized by acute kidney injury in the setting o...
Anticoagulation-related nephropathy (ARN) is a significant and underdiagnosed complication in patients who receive anticoagulation therapy. It is characterized by acute kidney injury in the setting of excessive anticoagulation defined as an international normalized ratio > 3.0 in patients treated with warfarin. A definitive diagnosis is made by renal biopsy showing acute tubular necrosis with obstruction of the tubuli by red blood cell casts. However, the evidence shows that ARN can occur during treatment with novel oral anticoagulants as well. Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge. It is also reported that glomerular lesions (i.e., kidney disease) represent a risk factor for ARN. We present a case of an 82-year-old man who developed biopsy-proven ARN after the administration of dual antiplatelet therapy with no previous anticoagulation treatment and normal coagulation tests.
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- Primary malignant melanotic melanoma and hypomelanotic melanoma of the female urethra: case series and a review of the literature in China. [Journal Article]
- MRMelanoma Res 2018 Nov 02
- The incidence of primary malignant melanoma (MM) of female urethra is extremely low, leading to paucity of recommendations on management. The objectives of our study were to gain more insight into th...
The incidence of primary malignant melanoma (MM) of female urethra is extremely low, leading to paucity of recommendations on management. The objectives of our study were to gain more insight into the clinical features, diagnosis, treatment, and prognosis of this rare type of tumor. We carried out a retrospective analysis of all four cases who underwent an operation in our hospital since 1980. Moreover, other 32 cases of MM that have been reported in Chinese papers were also included for further review. The age of the patients ranged from 38 to 81 years. A mass in the urethral meatus and hematuria are common presentations. The final diagnosis depends on histopathological examination. After surgery alone or combined with chemotherapy/radiotherapy/immunotherapy, all cases were followed for 1-151 months, whereas only one lived for more than 4 years after receiving the diagnosis. A timely and accurate diagnosis of MM is critical, especially for hypomelanotic and amelanotic cases. Immunohistochemical staining and electron microscopy are necessary for a precise diagnosis in some cases. Extensive resection, early chemotherapy, and immunotherapy may help to improve survival.