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Unbound Medicine.
(Hertwig root sheath)
31 results
  • Mesenchymal stem cell-based tissue regeneration therapies for periodontitis. [Review]
    Regen Ther. 2020 Jun; 14:72-78.Ouchi T, Nakagawa T
  • Periodontitis is commonly observed and is an important concern in dental health. It is characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical stress, and systemic diseases such as diabetes mellitus. The current standard treatments for periodontitis include elimination of the microbial pathogen and application of biomaterials for treating bone defects. Howev…
  • Aberrant root formation - An unreported complication of dental trauma. [Case Reports]
    J Indian Soc Pedod Prev Dent. 2018 Apr-Jun; 36(2):216-219.Revathy V, Abirami R, Abharna R
  • Trauma and infection to immature teeth can result in a number of complications. Discontinuity in the formation of root is one such complication which has never been documented before. In the following article, a case report of this aberrancy which was observed in the root of a permanent central incisor, subsequent to a traumatic injury is discussed. In spite of this discontinuity, complete root f…
  • Harmine promotes molar root development via SMAD1/5/8 phosphorylation. [Journal Article]
    Biochem Biophys Res Commun. 2018 03 11; 497(3):924-929.Fujiwara N, Lee JW, … Ota MS
  • Tooth and bone are major tissues involved in physiological calcification in the body, and they use similar molecular pathways for development, homeostasis, and regeneration. Harmine (HMN) is a natural small compound that stimulates osteoblast differentiation in vitro and in vivo. Here we examined the biological effect of HMN on the postnatal development of molar tooth roots and periodontal tissue…
  • Localization of RELM-β/FIZZ2 Is Associated with Cementum Formation. [Journal Article]
    Anat Rec (Hoboken). 2017 Oct; 300(10):1865-1874.Hosoya A, Takahama A, Nakamura H
  • Resistin-like molecule-β/found in inflammatory zone 2 (RELM-β/FIZZ2) is a cysteine-rich secretory protein that is localized in the epithelium of the gastrointestinal tract and lung alveoli. Previous reports have suggested that this protein regulates glucose metabolism and inflammation. In the present study, to analyze the involvement of RELM-β/FIZZ2 in tooth development, we immunohistochemically …
  • CBX7 deficiency plays a positive role in dentin and alveolar bone development. [Journal Article]
    J Mol Histol. 2016 Aug; 47(4):401-11.Zhou Z, Yin Y, … Shen M
  • To clarify the role of CBX7 deficiency in dentin and alveolar bone development, the dental and mandibular phenotypes of homozygous CBX7-knockout (CBX7(-/-)) mice were compared with their wild-type (WT) counterparts at 3 weeks age. In contrast to WT littermates, dental volume and dentin sialoprotein-positive area were significantly increased, whereas the area ratio of predentin to dentin was decre…
  • Unusual root development following surgical repositioning of horizontally developing central incisor. [Case Reports]
    Dent Traumatol. 2015 Oct; 31(5):413-7.Bhatia SK, Goyal A, … Acharya S
  • Dilaceration is one of the causes of maxillary central incisor eruption failure. If the dilacerated maxillary permanent central incisor is in a horizontal or vertical position and root formation is in early stages, surgical repositioning is frequently the treatment of choice. In this article, the case of a horizontally impacted and dilacerated maxillary central incisor is presented which was trea…
  • Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development. [Journal Article]
    J Periodontal Res. 2015 Dec; 50(6):714-20.Kira-Tatsuoka M, Oka K, … Sawa Y
  • CONCLUSIONS: Our results suggest that both fibrillin-1 and fibrillin-2 expression is required to form thick oxytalan fibers in PDL. Based on the expression patterns for fibrillin-1 and fibrillin-2, they have different functions during tooth root and PDL development. Early expression of fibrillin-2 may regulate dental epithelial cell behavior during root and PDL development.
  • Post-traumatic apexogenesis of immature non-vital permanent incisors. [Case Reports]
    J Coll Physicians Surg Pak. 2012 Jul; 22(7):452-4.Ghafoor R
  • Injury to an immature permanent tooth may result in cessation of dentin deposition and root maturation leaving an open root apex and thin dentinal walls that are prone to fracture. Endodontic treatment is often complicated and protracted with an uncertain prognosis frequently resulting in pre-mature tooth loss. There are several advantages of promoting apexogenesis in immature teeth with open api…
  • Palatogingival groove - a silent killer: Treatment of an osseous defect due to it. [Case Reports]
    J Indian Soc Periodontol. 2011 Apr; 15(2):169-72.Gupta KK, Srivastava A, … Gupta J
  • A male patient of 21 years of age reported to the Department of Periodontology and Implantology with a chief complain of pus discharge in both right and left upper lateral incisors. On clinical examination a deep pocket of about 10-14 mm was noticed in both lateral incisors. Radiographic interpretation shows a teardrop-shaped radiolucency in both the laterals giving suspicion of palatogingival gr…
  • Fenestration defects in the rabbit jaw: an inadequate model for studying periodontal regeneration. [Journal Article]
    Tissue Eng Part C Methods. 2010 Feb; 16(1):133-40.Oortgiesen DA, Meijer GJ, … Jansen JA
  • Periodontitis is an inflammatory disease affecting the support of the teeth, eventually leading to loosening and subsequent loss of teeth. Effective procedures for periodontal tissue engineering or regeneration require preclinical models before market introduction. Research has been performed in either small or large animals. Unfortunately, there is no intermediate-sized in vivo model available f…
  • NO-cGMP signaling molecules in the rat epithelial rests of Malassez. [Journal Article]
    Eur J Oral Sci. 2004 Feb; 112(1):55-60.Korkmaz Y, Bloch W, … Baumann MA
  • The epithelial rests of Malassez (ERM) are derived from the disintegrating epithelial root sheath of Hertwig that guides root formation during tooth development. Low concentrations of nitric oxide (NO) produced by NO-synthase I (NOS I) and NOS III activate intracellular soluble guanylate cyclase (sGC) to produce intracellular cyclic guanosine 3':5'-monophosphate (cGMP), which triggers rapid cellu…
  • [Epithelial cell rests of Malassez: tissue, cell, and molecular biology]. [Review]
    Morfologiia. 2003; 124(4):95-103.Bykov VL
  • This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez (ERM), which are formed by persisting fragments of epithelial (Hertwig) sheath that participates in the tooth root development. ERM, found within the periodontal ligament, undergo intensive age-related involution and are traditionally …
  • Cytokeratins in epithelia of odontogenic neoplasms. [Journal Article]
    Oral Dis. 2003 Jan; 9(1):1-6.Crivelini MM, de Araújo VC, … de Araújo NS
  • Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. The immunohistochemical detection of different cytokeratins (CKs) polypeptides and vimentin has made it easier to explain the histogenesis of many epithelial diseases. The present study aimed to describe the immunohistochemical expre…
  • Continued apexogenesis of immature permanent incisors following trauma. [Case Reports]
    Br Dent J. 1999 Dec 25; 187(12):643-4.Welbury R, Walton AG
  • Two cases of trauma to immature teeth are described which differed significantly in their initial severity. However, both subsequently presented with continued apical root formation. In the two cases a histological examination after tooth removal confirmed continued apical development of the traumatised immature teeth distant to their respective coronal portions. These cases highlight the resilie…
  • [Rare case of hypertaurodontism]. [Case Reports]
    Rev Stomatol Chir Maxillofac. 1984; 85(3):245-7.Moreau JL
  • The author observed a rare case of hypertaurodontism on a right lower molar n degree 2, with an apex like a lion's paw, a very low root trifurcation, but a normal ratio between the coronary and the radicular lengths. This anomaly may be due to an absence of any sub-coronary horizontal invagination in the Hertwig sheath, which would be hereditarily transmitted.
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