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128,642 results
  • A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo. [Journal Article]
    Nat Genet 2020Nakamori M, Panigrahi GB, … Pearson CE
  • In many repeat diseases, such as Huntington's disease (HD), ongoing repeat expansions in affected tissues contribute to disease onset, progression and severity. Inducing contractions of expanded repeats by exogenous agents is not yet possible. Traditional approaches would target proteins driving repeat mutations. Here we report a compound, naphthyridine-azaquinolone (NA), that specifically binds …
  • Composition and structure of cell wall ulvans recovered from Ulva spp. along the Swedish west coast. [Journal Article]
    Carbohydr Polym 2020; 233:115852Wahlström N, Nylander F, … Albers E
  • The cell wall polysaccharide ulvan was isolated from two species of the seaweed Ulva collected along the Swedish west coast. Acidic extraction was benchmarked against hot water extraction with enzymatic purification and against commercial ulvan. Extracted ulvan contained 11-18 % g/g of ash, some protein (up to 1.3 % g N/g) but minimal colored impurities. The ulvans had high molecular weights (660…
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