- Burden of Hypertensive Crisis in Patients With End-Stage Kidney Disease on Maintenance Dialysis: Insights From United States Renal Data System Database. [Journal Article]Hypertension. 2023 Feb 08 [Online ahead of print]H
- CONCLUSIONS: Hospitalizations for HTN-C have increased consistently during the decade studied. Although temporal trends showed improving mortality and readmission rates, the absolute rates were still high with 1 in 3 patients readmitted within 30 days and 1 in 5 patients dying within 1 year of index hospitalization.
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- Altered Neuronal Discharge in the Organum Vasculosum of the Lamina Terminalis Contributes to Dahl Salt-Sensitive Hypertension. [Journal Article]Hypertension. 2023 Feb 08 [Online ahead of print]H
- CONCLUSIONS: A high-salt diet activates NaCl-responsive OVLT neurons to increase SNA and arterial blood pressure in salt-sensitive hypertension.
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- An Unusual Case of Severe Pneumonia Caused Due Candida Tropicalis With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community. [Journal Article]J Investig Med High Impact Case Rep. 2023 Jan-Dec; 11:23247096231154652.JI
- Severe pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient. A 72-year-old man with a previous history of hypertension, ischemic stroke, and facial paralysis sequelae treated with the botulinic toxin, was admitte…
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- Significant Improvement in Blood Pressure Levels Among Older Adults With Hypertension in Rural South Africa. [Journal Article]Hypertension. 2023 Feb 08 [Online ahead of print]H
- CONCLUSIONS: The hypertension prevalence and incidence are plateauing in this aging cohort. There was a statistically and clinically significant decline in mean blood pressure and a substantial increase in individuals with controlled hypertension on medication. The prevalence of cardiometabolic risk factors did not decrease over time, suggesting that the blood pressure decrease is likely due to increased medication access and adherence, promoted by local health systems.
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- Loneliness-a clinical primer. [Journal Article]Br Med Bull. 2023 Feb 07 [Online ahead of print]BM
- CONCLUSIONS: due to increased individualization and incidence of infectious diseases, loneliness is likely to become even more prevalent.more research is needed to further elucidate the health impacts of loneliness as well as to find evidence-based interventions to prevent and mitigate loneliness that could then be implemented by policy-makers and clinicians.
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- Escherichia coli-derived outer-membrane vesicles induce immune activation and progression of cirrhosis in mice and humans. [Journal Article]Liver Int. 2023 Feb 08 [Online ahead of print]LI
- CONCLUSIONS: In conclusion, OMVs induce inflammation, fibrosis and suppression of albumin production, affecting the pathogenesis of cirrhosis. We believe that our study paves the way for the future prevention and treatment of cirrhosis.
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- Geriatric Pharmacotherapy Case Series: Recurrent Angioedema Following Discontinuation of ACE Inhibitor Therapy. [Journal Article]Sr Care Pharm. 2023 Jan 01; 38(1):16-20.SC
- Introduction Angiotensin-converting enzyme inhibitors (ACEIs) are first-line pharmaceutical agents in common chronic conditions such as hypertension and heart failure with reduced ejection fraction. When angioedema occurs, if secondary to ACEIs, discontinuation of the ACEI is necessary to mitigate the risk of recurrent angioedema. While angioedema is a well-known adverse effect of ACEIs, it is no…
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- Effect of omega-3 fatty acid use on sepsis and mortality in patients with Covıd-19. [Journal Article]Niger J Clin Pract. 2023 Jan; 26(1):102-108.NJ
- CONCLUSIONS: Study results obtained in this study indicate that providing omega-3 fatty acid supplements may be beneficial to patients with severe COVİD-19, however further research with large-scale randomized controlled trials is necessary.
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- Study of central aortic blood pressure in hypertensive patients & its relation with blood pressure-lowering drugs. [Journal Article]Indian J Med Res. 2022 Sep; 156(3):524-528.IJ
- CONCLUSIONS: Hypertension is diagnosed mainly by measuring peripheral BP. CBP, which correlates better with the incidence of cardiovascular events, is not routinely measured. Patients with a history of hypertension and on treatment had normal office peripheral BP, but a few of them had high CBP and may require modification in treatment for control of CBP. Control of CBP was better in patients taking CCB.
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- Novel phenotype of aortic root dilatation and late-onset metabolic decompensation in a patient with TMEM70 deficiency. [Case Reports]Am J Med Genet A. 2023 Feb 07 [Online ahead of print]AJ
- TMEM70 deficiency causing mitochondrial complex V deficiency, nuclear type 2 (MIM: 614052) is the most common nuclear encoded defect affecting ATP synthase and has been well described in the literature as being characterized by neonatal or infantile onset of poor feeding, hypotonia, lethargy, respiratory compromise, heart failure, lactic acidosis, hyperammonemia, and 3-methylglutaconic aciduria p…
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- Pulmonary hypertension: the hallmark of acute COVID-19 microvascular angiopathy? [Journal Article]ERJ Open Res. 2023 Jan; 9(1)EO
- In situ pulmonary arterial thrombosis in COVID-19 is not visible on CTPA. However, the presence of CT-measured right heart and pulmonary artery dilatation in COVID-19 is likely attributable to this process and may be a possible surrogate for its detection. https://bit.ly/3g7z5TV.
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- Cumulative Human Immunodeficiency Virus (HIV)-1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019. [Journal Article]Open Forum Infect Dis. 2023 Feb; 10(2):ofac702.OF
- CONCLUSIONS: Among ART-treated WWH, greater cumulative viremia increased the risk of multimorbidity and of developing each NACM, and hence this may be a prognostically useful biomarker for NACM risk assessment in this population.
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- Ameliorated nailfold capillary morphology of patients with pulmonary arterial hypertension in systemic sclerosis, treated with riociguat. [Case Reports]Rheumatol Adv Pract. 2023; 7(1):rkad011.RA
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- Factors associated with post traumatic hydrocephalus following decompressive craniectomy: A single-center experience. [Journal Article]Surg Neurol Int. 2023; 14:18.SN
- CONCLUSIONS: This study concludes that cerebellar hematoma (and contusions) are associated with developing PTH in patients undergoing DC.
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- 24-hour central blood pressure and immune system activation in adolescents with primary hypertension - a preliminary study. [Journal Article]Cent Eur J Immunol. 2022; 47(2):160-167.CE
- CONCLUSIONS: Increased central 24-h blood pressure may be associated with immune system activation in adolescents with primary hypertension. In adolescents with primary hypertension, dyslipidemia and hyperuricemia are risk factors for increased arterial stiffness. Further studies on central and peripheral blood pressure in terms of their relationship with inflammation in these patients are needed.
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- Rhabdomyolysis: An evidence-based approach. [Journal Article]J Intensive Care Soc. 2022 Nov; 23(4):513-517.JI
- A 76-year-old lady was found on the floor following a fall at home. She was uninjured, but unable to get up, and had been lying on the floor for roughly 18 hours before her son arrived. She had been unwell for the past 3 days with a cough and shortness of breath. She had a past medical history of diabetes, hypertension, hypercholesterolaemia and atrial fibrillation (AF). On examination, she was a…
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- Association of CHA2DS2-VASc score with successful recanalization in acute ischemic stroke patients undergoing endovascular thrombectomy. [Journal Article]Postepy Kardiol Interwencyjnej. 2022 Sep; 18(3):269-275.PK
- CONCLUSIONS: For the first time in the literature, we investigated and demonstrated that pre-stroke CHA2DS2-VASc score was associated with success of recanalization as assessed with mTICI 2c and mTICI 3 in a cohort of AIS patients regardless of AF presence who underwent endovascular treatment. Our findings deserve to be tested with large scale long term studies.
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- Bronchial Asthma Exacerbation in the Emergency Department in a Saudi Pediatric Population: An Insight From a Tertiary Hospital in Riyadh, Saudi Arabia. [Journal Article]Cureus. 2023 Jan; 15(1):e33391.C
- Background Severe uncontrolled asthma in the pediatric population is a complicated disease and is considered a major challenge for pediatricians. Severe bronchial asthma in the pediatric population is related to significant morbidity and mortality. Children with complicated asthma are at a higher risk for unfavorable outcomes, including medication-associated adverse effects, severe life-threateni…
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- Supplementation of Water-Soluble Vitamins Reduces Hyperhomocysteinemia, Insulin Resistance, and High-Sensitivity C-reactive Protein in Prehypertension Subjects. [Journal Article]Cureus. 2023 Jan; 15(1):e33481.C
- CONCLUSIONS: In subjects with prehypertension, supplementation of water-soluble vitamins decreases the level of homocysteine, insulin resistance, and hs-CRP.
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- Idiopathic Multicentric Castleman Disease Presenting With Hypertensive Choroidopathy: A Case Report. [Case Reports]Cureus. 2023 Jan; 15(1):e33368.C
- Castleman disease (CD) is a lymphoproliferative disorder and rarely affects ocular tissue. This study aimed to report a case of hypertensive choroidopathy in a patient with Castleman's disease associated with malignant hypertension. A 39-year-old man visited his local physician with fever, systemic edema, and multiple lymphadenopathies. An inguinal lymph node biopsy indicated CD. One month after …
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- Effect of Phosphodiesterase-5 (PDE-5) Inhibitors on Clinical Outcomes in Patients With Pulmonary Hypertension: A Meta-Analysis of Randomized Control Trials. [Review]Cureus. 2023 Jan; 15(1):e33363.C
- We intended to summarize the most recent research pertaining to the use of phosphodiesterase-5 (PDE5) inhibitors in pulmonary hypertension in light of recent developments in the knowledge of the pathophysiological mechanisms and treatments for pulmonary hypertension, with major contributions in the area in the last decade. The aim of this meta-analysis is to determine the efficacy of PDE5 inhibit…
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- Effect of Chest Physiotherapy on Improving Pulmonary Function in Dealing With Congenital Heart Disease and Lung Collapse: A Case Report. [Case Reports]Cureus. 2023 Jan; 15(1):e33433.C
- Patent ductus arteriosus (PDA) is a condition in which the ductus arteriosus fails to close after birth. We present the case of a three-month-old female infant admitted to a tertiary care center with the complaint of cough, poor feeding, and breathing difficulties. Based on the investigatory finding, she was diagnosed with PDA with pulmonary arterial hypertension (PAH), an atrial septal defect (A…
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- Coronary Artery Disease in Systemic Lupus Erythematosus: What Do the Facts Say? [Review]Cureus. 2023 Jan; 15(1):e33449.C
- Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect any organ with a predisposition for women of reproductive age. It is related to a higher risk of cardiovascular events, increasing it up to 50 times in young people, and 30% of deaths are attributed to coronary artery disease. The risk of developing cardiovascular disease in SLE is related not only to traditional cardiova…
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- Non-Dipper Blood Pressure Impact on Coronary Slow Flow in Hypertensive Patients With Normal Coronary Arteries. [Journal Article]Cureus. 2023 Jan; 15(1):e33356.C
- CONCLUSIONS: In this study, non-dipper patients had a greater CSF rate than dipper.
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- MiR-3646 accelerates inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis in hypertension model. [Journal Article]Clin Exp Hypertens. 2023 Dec 31; 45(1):2166948.CE
- CONCLUSIONS: MiR-3646 accelerated inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis. Our findings illustrated the specific molecular mechanism of miR-3646 regulating hypertension.
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- Effect of Motor Competence and Health-Related Fitness in the Prevention of Metabolic Syndrome Risk Factors. [Journal Article]Res Q Exerc Sport. 2023 Feb 07 [Online ahead of print]RQ
- Purpose: In the last decades we have seen an increase in sedentary behaviors and a decrease in physical activity in children when compared to past generations. This lifestyle is commonly associated with the development of clustering risk factors that define metabolic syndrome (MetS). Knowing that motor competence (MC) development can influence lifelong physical activity habits, it is reasonable t…
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- Using a patient-centred composite endpoint in a secondary analysis of the Control of Hypertension in Pregnancy Study (CHIPS) Trial. [Journal Article]Trials. 2023 Feb 07; 24(1):99.T
- CONCLUSIONS: Evidence-based recommendations for 'tight' control are consistent with most women's preferences, but for a sixth of women, 'less-tight' control is more preference consistent. Depending on patient preferences, a single trial may support different interventions. Future trials should specify component weights to improve interpretation.
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- Risk factors combine in a complex manner in assessment for macrosomia. [Journal Article]BMC Public Health. 2023 Feb 07; 23(1):271.BP
- CONCLUSIONS: Macrosomia was related to several common, modifiable risk factors. Some factors have combined effects on macrosomia (e.g., pre-pregnancy overweight/obesity and diabetes), whereas gestational hypertension varies by maternal age. Strategies based on pre-pregnancy risk factors should be given more attention to reduce the burden of macrosomia.
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- Endovascular treatment of aorto-iliac occlusive disease with TASC II C and D lesions: 10 year's experience of clinical technique. [Journal Article]BMC Cardiovasc Disord. 2023 Feb 07; 23(1):71.BC
- CONCLUSIONS: Endovascular treatment of AIOD patients with TASC-II C and D lesions might be safe and have a high rate of middle-term and long-term primary patency.
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- Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial. [Journal Article]Trials. 2023 Feb 07; 24(1):94.T
- CONCLUSIONS: The results of this research may help in the real understanding of the nutritional compounds capable of generating safety to the cardiovascular system during physical exercise, especially for women who are aging and who have cardiovascular limitations (e.g., arterial hypertension) to perform physical exercise. Therefore, our results will be able to help specific nutritional recommendations to optimize cardiovascular health.
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