- Drug Eruption From Atorvastatin: With Initial Misdiagnosis of Tinea Cruris. [Journal Article]Sr Care Pharm. 2023 Feb 01; 38(2):63-69.SC
- Objective To present the case of a Latin man 68 years of age who presented to the emergency department with a rash to the right side of his groin 10 weeks after switching from simvastatin 40 mg daily to atorvastatin 40 mg daily. Background Prior to switching to atorvastatin, the patient had been taking simvastatin for 21 years without rash. The rash progressed bilaterally to his arms and hands, l…
- Publisher Full Text (DOI)
- Diabetic Foot Risk Assessment among Patients with Type 2 Diabetes in Kenya. [Journal Article]East Afr Health Res J. 2022; 6(2):196-202.EA
- CONCLUSIONS: Our results show high rates of obesity, and poor glycaemic control in patients with type 2 diabetes and 56.5% of patients are categorised as being a moderate-to-high risk for foot problems. This highlights the need for healthcare professionals and patients in Kenya to be sensitised regarding the importance of foot screening to prevent lower-extremity complications.
- PMC Free PDF
- Association Between Hypocholesterolemia and Mortality in Critically Ill Patients With Sepsis: A Systematic Review and Meta-Analysis. [Review]Crit Care Explor. 2023 Feb; 5(2):e0860.CC
- CONCLUSIONS: Mortality was associated with lower levels of total cholesterol, HDL-cholesterol, and LDL-cholesterol, but not triglyceride levels, in patients admitted to ICU with sepsis. The impact of cholesterol replacement on patient outcomes in sepsis, particularly in at-risk groups, merits investigation.
- PMC Free PDF
- 24-hour central blood pressure and immune system activation in adolescents with primary hypertension - a preliminary study. [Journal Article]Cent Eur J Immunol. 2022; 47(2):160-167.CE
- CONCLUSIONS: Increased central 24-h blood pressure may be associated with immune system activation in adolescents with primary hypertension. In adolescents with primary hypertension, dyslipidemia and hyperuricemia are risk factors for increased arterial stiffness. Further studies on central and peripheral blood pressure in terms of their relationship with inflammation in these patients are needed.
- PMC Free PDF
- Effect of Motor Competence and Health-Related Fitness in the Prevention of Metabolic Syndrome Risk Factors. [Journal Article]Res Q Exerc Sport. 2023 Feb 07 [Online ahead of print]RQ
- Purpose: In the last decades we have seen an increase in sedentary behaviors and a decrease in physical activity in children when compared to past generations. This lifestyle is commonly associated with the development of clustering risk factors that define metabolic syndrome (MetS). Knowing that motor competence (MC) development can influence lifelong physical activity habits, it is reasonable t…
- Publisher Full Text (DOI)
- Association of plasma lipid metabolism profiles with overall survival for patients with gastric cancer undergoing gastrectomy based on 1H-NMR spectroscopy. [Journal Article]Nutr Metab (Lond). 2023 Feb 07; 20(1):7.NM
- CONCLUSIONS: This study found that the index derived from the LDL-5 Apo-B, LDL-4 Cholesterol, HDL-4 Apo-A2, and HDL-4 Free Cholesterol, was significantly associated with overall survival, suggesting that regulating lipid metabolisms might improve the prognosis for GC patients.
- Publisher Full Text (DOI)
- Association of triglycerides to high-density lipoprotein cholesterol ratio with incident cardiovascular disease but not end-stage kidney disease among patients with biopsy-proven diabetic nephropathy. [Journal Article]Hypertens Res. 2023 Feb 07 [Online ahead of print]HR
- Increased triglycerides (TG) and decreased high-density lipoprotein cholesterol (HDL-C) are dyslipidemias characteristic of diabetes. Here, we aimed to examine associations of TG/HDL-C ratio with cardiovascular disease (CVD) and kidney dysfunction among patients with diabetic nephropathy. This retrospective observational study consists of patients with biopsy-proven diabetic nephropathy at Nara M…
- Publisher Full Text (DOI)
- Factors associated with relapse of type 2 diabetes mellitus after laparoscopic sleeve gastrectomy in Japanese subjects: a subgroup analysis of J-SMART study. [Journal Article]Obes Facts. 2023 Feb 07 [Online ahead of print]OF
- CONCLUSIONS: While LSG provides a high remission rate for T2DM, relapse is not uncommon. Preoperative HbA1c, poor weight loss and excess weight regain after LSG contribute to diabetes relapse, suggesting the importance of treatment strategies focusing on these factors.
- Publisher Full Text (DOI)
- Explainable Machine Learning Techniques To Predict Amiodarone-Induced Thyroid Dysfunction Risk: Multicenter, Retrospective Study With External Validation. [Journal Article]J Med Internet Res. 2023 Feb 07; 25:e43734.JM
- CONCLUSIONS: Machine learning models combined with resampling methods can predict amiodarone-induced thyroid dysfunction and serve as a support tool for individualized risk prediction and clinical decision support.
- Publisher Full Text (DOI)
- The association between HDL-C and stroke in the middle-aged and elderly: A cross-sectional study. [Journal Article]Brain Behav. 2023 Feb 07 [Online ahead of print]BB
- CONCLUSIONS: We found a nonlinear relationship between HDL-C and total stroke. Our study reveals a range of inverse associations between HDL-C and stroke (HDL-C<1.55 mmol/L), especially among men and Whites. This finding suggested that maintaining an appropriate HDL-C range may be beneficial in reducing the incidence of stroke.
- Publisher Full Text (DOI)
- Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 in Vitro. [Journal Article]Curr Drug Metab. 2023 Feb 07 [Online ahead of print]CD
- CONCLUSIONS: Compounds 1 and 2 showed a highly-selective and nanomolar affinity for CYP46A1 in vitro. These findings suggested that compounds 1 and 2 could be used as potent inhibitors of CYP46A1 in vitro.
- Publisher Full Text (DOI)
- The Effect of Statin Therapy on Serum Uric Acid Levels: A Systematic Review and Meta-Analysis. [Journal Article]Curr Med Chem. 2023 Feb 07 [Online ahead of print]CM
- CONCLUSIONS: Statins were significantly associated with a decrease in SUA levels, particularly atorvastatin, which was found to be most effective in lowering SUA. Atorvastatin may be the most appropriate cholesterol-lowering agent for patients with or at risk of hyperuricemia.
- Publisher Full Text (DOI)
- Atherosclerotic Cardiovascular Disease in Diabetes Patients. [Journal Article]Curr Diabetes Rev. 2023 Feb 06 [Online ahead of print]CD
- CONCLUSIONS: The risks for atherosclerotic complications of cardiovascular disease in type 2 DM patients in Medan were predominantly high. The variables related to ASCVD risks included age, gender, HbA1C, systolic blood pressure (SBP), total cholesterol levels, HDL-C, and LDL-C levels.
- Publisher Full Text (DOI)
- Salvia Miltiorrhiza Extract Prevents the Occurrence of Early Atherosclerosis in Apoe -/- Mice Via TLR4/ NF-Κb Pathway. [Journal Article]Cardiovasc Hematol Agents Med Chem. 2023 Feb 06 [Online ahead of print]CH
- CONCLUSIONS: These findings indicated that SABP may exert an anti-atherosclerotic effect by lowering blood lipids and inhibiting inflammatory response via TLR4/ NF-κB signaling pathway.
- Publisher Full Text (DOI)
- Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM. [Journal Article]Int J Endocrinol. 2023; 2023:6991633.IJ
- CONCLUSIONS: Lower HDL-C was an independent predictor for a high degree of IPFD.
- PMC Free PDF
- Hepatitis B virus infection combined with nonalcoholic fatty liver disease: Interaction and prognosis. [Review]Heliyon. 2023 Jan; 9(1):e13113.H
- Hepatitis B virus (HBV) infection is still one kind of the infectious diseases that seriously threaten human health. Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. HBV infection complicated with NAFLD is increasingly common. This review mainly describes the interaction between HBV infection and NAFLD, the interaction between steatosis and anti…
- PMC Free PDF
- Improving the Prediction of Death from Cardiovascular Causes with Multiple Risk Markers. [Preprint]medRxiv. 2023 Jan 23M
- CONCLUSIONS: The addition of clinical blood biomarkers and blood counts substantially improves CVD mortality prediction, beyond traditional risk factors. These biomarkers may serve as an important clinical and public health screening tool for the prevention of CVD deaths.
- PMC Free PDF
- How Did the Updated 2019 European Society of Cardiology/European Atherosclerosis Society Risk Categorization for Patients with Diabetes Affect the Risk Perception and Lipid Goals? A Simulated Analysis of Real-life Data from EPHESUS Study. [Journal Article]Anatol J Cardiol. 2023 Feb; 27(2):78-87.AJ
- CONCLUSIONS: The control of dyslipidemia was extremely poor among patients with diabetes. The use of lipid-lowering treatment was not at the desired level, and high-intensity lipid-lowering treatment use was even lower. Our simulation model showed that the high-dose statin plus ezetimibe therapy would improve goal attainment; however, it would not be possible to get goals with this treatment in more than one-third of the patients.
- Publisher Full Text (DOI)
- Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol. [Journal Article]BMC Med. 2023 Feb 06; 21(1):42.BM
- CONCLUSIONS: RC is independently associated with joint arteriosclerosis and atherosclerosis progression beyond LDL-C. RC could be an earlier risk factor than LDL-C of arteriosclerosis and atherosclerosis in the general population.
- Publisher Full Text (DOI)
- Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study. [Journal Article]BMC Med. 2023 Feb 06; 21(1):43.BM
- CONCLUSIONS: Maternal compared to paternal TC, HDL-C, and apoA1 levels were more strongly and consistently associated with offspring body weight during childhood, supporting a direct intrauterine effect.
- Publisher Full Text (DOI)
- Clinical significance of dynamic variation of low cholesterol and its prognostic value in patients with pyogenic liver abscesses: a retrospective study. [Journal Article]BMC Infect Dis. 2023 Feb 06; 23(1):70.BI
- CONCLUSIONS: Low TC level on admission is an independent risk factor for the progression of severe illness in PLA patients, with the highest predictive value surpassing other routine clinical indices. Abscess drainage should be performed as soon as possible for patients whose TC continues to decline after medical treatment.
- Publisher Full Text (DOI)
- Consolidation of metabolomic, proteomic, and GWAS data in connective model of schizophrenia. [Journal Article]Sci Rep. 2023 Feb 06; 13(1):2139.SR
- Despite of multiple systematic studies of schizophrenia based on proteomics, metabolomics, and genome-wide significant loci, reconstruction of underlying mechanism is still a challenging task. Combination of the advanced data for quantitative proteomics, metabolomics, and genome-wide association study (GWAS) can enhance the current fundamental knowledge about molecular pathogenesis of schizophren…
- Publisher Full Text (DOI)
- Low-dose and repeated exposure to nickel leads to bioaccumulation and cellular and metabolic alterations in quails. [Journal Article]Environ Pollut. 2023 Feb 04 [Online ahead of print]EP
- Nickel (Ni) is a widespread environmental pollutant commonly released into effluent due to industrial activities, the use of fuels, or wastewater disposal. Many studies confirm the toxic effects of this heavy metal. However, there is a lack of knowledge and data on bioaccumulation patterns in tissues as well as cellular and molecular responses following the exposure of living organisms to Ni. In …
- Publisher Full Text (DOI)
- Remnant Cholesterol and Common Carotid Artery Intima-Media Thickness in Community Population with Normal Low-Density Lipoprotein Cholesterol. [Journal Article]Cerebrovasc Dis. 2023 Feb 06 [Online ahead of print]CD
- CONCLUSIONS: Elevated fasting remnant cholesterol levels were positively associated with abnormal cIMT in community population with normal LDL-C levels. Remnant cholesterol may be an important indicator of risk stratification in community population with normal LDL-C level.
- Publisher Full Text (DOI)
- Gallstone Pancreatitis Post-Cesarean Section: A Case Report. [Journal Article]S D Med. 2022 Aug; 75(suppl 8):s20.SD
- Acute gallstone pancreatitis is a rare occurrence in pregnancy and the postpartum period. However, gallstone pancreatitis should be considered in a differential diagnosis for right upper quadrant (RUQ) pain in this population, as the risk of biliary stasis and gallstone formation increases in pregnancy due to high levels of circulating estrogen causing increased cholesterol formation and delayed …
- The Impact and Perception of England's Web-Based Heart Age Test of Cardiovascular Disease Risk: Mixed Methods Study. [Journal Article]JMIR Cardio. 2023 Feb 06; 7:e39097.JC
- CONCLUSIONS: England's web-based HAT has engaged large number of people in their heart health. Improvements to England's HAT, noted in this paper, may enhance user satisfaction and prevent confusion. Future studies to understand the long-term benefit of the test on behavioral outcomes are warranted.
- Publisher Full Text (DOI)
- PCSK9 Involves in the High-fat Diet-induced Abnormal Testicular Function of Male Mice. [Journal Article]Reproduction. 2023 Feb 01 [Online ahead of print]R
- Long-term consumption of a high-fat diet (HFD) is an important factor that leads to impaired spermatogenesis exhibiting poor sperm quantity and quality. However, the mechanism of which is yet to be elucidated. Disrupted cholesterol homeostasis is one of many crucial pathological factors which contributed to impaired spermatogenesis. As a negative regulator of cholesterol metabolism, preprotein in…
- Publisher Full Text (DOI)
- The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats. [Journal Article]Can J Physiol Pharmacol. 2023 Feb 06 [Online ahead of print]CJ
- The antioxidant effect of caffeine, associated with its ability to upregulate the nuclear factor-E2-related factor-2 (Nrf2)-signaling pathway, was explored as a possible mechanism for the attenuation of liver damage. Nonalcoholic steatohepatitis (NASH) was induced in rats by the administration of a high-fat, high-sucrose, high-cholesterol diet (HFSCD) for 15 weeks. Liver damage was induced in rat…
- Publisher Full Text (DOI)
- A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson's disease. [Journal Article]
- Genetic and environmental factors lead to the manifestation of Parkinson's disease (PD) but related mechanisms are only rudimentarily understood. Cytochromes P450 (P450s) are involved in the biotransformation of toxic compounds and in many physiological processes and thus predestinated to be involved in PD. However, so far only SNPs (single nucleotide polymorphisms) in CYP2D6 and CYP2E1 have been…
- PMC Free PDF