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Unbound Medicine.
(Hirudinea)
4,053 results
  • A Comprehensive Review of Medicinal Leeches in Plastic and Reconstructive Surgery. [Journal Article]
    Plast Reconstr Surg Glob Open. 2019 Dec; 7(12):e2555.Hackenberger PN, Janis JE
  • Medicinal leeches are a US Food and Drug Administration-approved treatment for venous congestion in graft tissue to promote healing and can serve as a nonsurgical option for plastic surgery patients with concern for tissue compromise. Although there is a wealth of documentation on medicinal leech therapy, the surgical space currently lacks an updated summary of proper indications, use, and risks …
  • Complications of leech therapy. [Review]
    Avicenna J Phytomed. 2020 May-Jun; 10(3):222-234.Pourrahimi M, Abdi M, Ghods R
  • CONCLUSIONS: Leech therapy can be a therapeutic complementary method if the possible complications are managed properly.
  • Detailed ultrastructure of the Hirudo (Annelida: Hirudinea) salivary gland. [Journal Article]
    Micron. 2020 Sep; 136:102887.Saglam N, Saunders R, … Saidel WM
  • Medical leeches have been widely used in medical applications and treatments for millennia. Studies on the salivary glands of blood-sucking leeches have focused on their bioactive secretions and mechanisms of action, with little attention to ultrastructure. In this study, we examined dissected embryonic and adult Hirudo verbana salivary glands by scanning electron microscopy (SEM). Gland cells of…
  • Leech Therapy Following Digital Replantation and Revascularization. [Review]
    J Hand Surg Am. 2020 May 31 [Online ahead of print]Pickrell BB, Daly MC, … Eberlin KR
  • Venous congestion after digital replantation or revascularization threatens digit survival in the immediate postoperative period. External bloodletting, including leech therapy, provides a central role in salvage of the congested finger. Although there have been previous studies describing the initiation of leech therapy for digits experiencing venous insufficiency, few published articles and no …
  • Brief Electrical Stimulation triggers an effective regeneration of Leech CNS. [Journal Article]
    eNeuro. 2020 May 29 [Online ahead of print]Cohen S, Richter-Levin A, Shefi O
  • The search for therapeutic strategies to promote neuronal regeneration following injuries towards functional recovery is of great importance. Brief low-frequency electrical stimulation (ES) has been reported as a useful method to improve neuronal regeneration in different animal models, however the effect of ES on single neuron behavior has not been shown. Here we study the effect of brief electr…
  • Intraspecific Variation in Growth and Reproduction of the Marine Leech, Heptacyclus buthi. [Journal Article]
    J Parasitol. 2020 Jun 01; 106(3):578-581.Kim BY, Buth DG
  • Heptacyclus buthi was harvested from fish hosts in rocky intertidal zones of Sonoma and Marin Counties, California, in October 2008 (n = 162) and October 2010 (n = 51). The size of the leeches was quantified using a method that approximated the sagittal cross-section of each specimen. Size-frequency curves were modeled to estimate the number of size-class cohorts in each year. If H. buthi is an a…
  • The hirudin-like factors HLF3 and HLF4-hidden hirudins of European medicinal leeches. [Journal Article]
    Parasitol Res. 2020 Jun; 119(6):1767-1775.Müller C, Lukas P, … Hildebrandt JP
  • The hirudin-like factors 3 (HLF3) and 4 (HLF4) belong to a new class of leech-derived factors and are present in specimens of the three European medicinal leeches, Hirudo medicinalis, Hirudo verbana, and Hirudo orientalis, respectively. Here we describe the functional analysis of natural and synthetic variants of HLF3 and HLF4. Whereas the natural variants display only very low or no detectable a…
  • European Medicinal Leeches-New Roles in Modern Medicine. [Review]
    Biomedicines. 2020 Apr 27; 8(5)Lemke S, Vilcinskas A
  • Before the advent of modern medicine, natural resources were widely used by indigenous populations for the prevention and treatment of diseases. The associated knowledge, collectively described as folk medicine or traditional medicine, was largely based on trial-and-error testing of plant extracts (herbal remedies) and the use of invertebrates, particularly medicinal maggots of the blowfly Lucili…
  • Hirudiniasis in Cattle in Mpwapwa District, Dodoma Region of Tanzania. [Case Reports]
    Case Rep Vet Med. 2020; 2020:3028345.Mulilo MA, Siwila J, … Silayo RS
  • Hirudiniasis is a condition caused by infestation by leeches. Despite the annoyance, clinical signs, and associated lesions caused by leeches in both humans and animals, the extent of the problem in Tanzania is not well elucidated. Individual animals and people become infested when they drink, bath, or walk through contaminated water sources. Leech infestations are more common in rural areas wher…
  • A Rare Cause of Hemoptysis: Oropharyngeal Leech [Journal Article]
    Turkiye Parazitol Derg. 2020 Mar 20; 44(1):61-63.Çıldır İ
  • We report the case of a 33-year-old patient who presented with dyspnea and hemoptysis due to an oropharyngeal leech infestation. The patient was a shepherd and his detailed history revealed that he had been drinking water from natural springs. In the examination, a vivid dark green colored foreign body moving towards the nasopharynx and hypopharynx was detected in the oropharynx. The leech was re…
  • Antimicrobial Role of RNASET2 Protein During Innate Immune Response in the Medicinal Leech Hirudo verbana. [Journal Article]
    Front Immunol. 2020; 11:370.Baranzini N, De Vito A, … Grimaldi A
  • The innate immune response represents a first-line defense against pathogen infection that has been widely conserved throughout evolution. Using the invertebrate Hirudo verbana (Annelida, Hirudinea) as an experimental model, we show here that the RNASET2 ribonuclease is directly involved in the immune response against Gram-positive bacteria. Injection of lipoteichoic acid (LTA), a key component o…
  • Purinergic modulation of neuronal gap junction circuits in the CNS of the leech. [Journal Article]
    J Neurosci Res. 2020 Jun; 98(6):1232-1249.Segura OM, Abdulnoor L, … Baker MW
  • Gap junctions (GJs) are widely distributed in brains across the animal kingdom. To visualize the GJ- coupled networks of two major mechanosensory neurons in the ganglia of medicinal leeches, we injected these cells with the GJ-permeable tracer Neurobiotin. When diffusion time was limited to only 30 min, tracer coupling was highly variable for both cells, suggesting a possible modulation of GJ per…
  • Draft Genome of the Asian Buffalo Leech Hirudinaria manillensis. [Journal Article]
    Front Genet. 2019; 10:1321.Guan DL, Yang J, … Qiu Q
  • The Asian Buffalo leech, Hirudinaria manillensis, is an aquatic sanguivorous species distributed widely in Southeast Asia. H. manillensis has long been used clinically for bloodletting and other medical purposes. Recent studies have focused on artificial culturing, strain optimization, and the identification and development new drugs based on the anticoagulant effects of H. manillensis bites; how…
  • Phase-Specific Motor Efference during a Rhythmic Motor Pattern. [Journal Article]
    J Neurosci. 2020 Feb 26; 40(9):1888-1896.Alonso I, Sanchez Merlinsky A, Szczupak L
  • Neuronal circuits that control motor behaviors orchestrate multiple tasks, including the inhibition of self-generated sensory signals. In the hermaphroditic leech, T and P mechanosensory neurons respond to light touch and pressure on the skin, respectively. We show that the low threshold T cells were also sensitive to topological changes of the animal surface, caused by contraction of the muscles…
  • [Effects of MT on growth and gonad development of natural overwintering Whitmania pigra]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2019 Oct; 44(20):4426-4432.Lu X, Guo QS, … Yan XL
  • The objectives of study were to explore the effects of exogenous methyltestosterone(MT) on the growth and gonadal development of overwintering Whitmania pigra. Before overwintering,0. 1,1. 0,10. 0,100. 0,150. 0 μg·L-1 of MT were added to the aquaculture water for 6 weeks. The changes of growth performance,gonad index,endogenous steroid hormones level and internal quality were measured after hiber…
  • Macrobenthic invertebrates as bioindicators of trace elements in high-mountain lakes. [Journal Article]
    Environ Sci Pollut Res Int. 2020 Feb; 27(6):5958-5970.Pastorino P, Pizzul E, … Squadrone S
  • Alpine lakes are extreme ecosystems located in remote areas and populated by few but well-adapted species. Because of their remote location, they are often considered pristine, unpolluted ecosystems. Since the 1980s, however, they have been affected by global anthropogenic impacts. Macrobenthic invertebrates play a pivotal role in these ecosystems and can be used as bioindicators also for monitor…
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